FlyBase Allele Report: Hsap\HNRNPA2B1[UAS.cSa]

General Information

Symbol

Hsap\HNRNPA2B1^UAS.cSa

Species

H. sapiens

Name

FlyBase ID

FBal0279774

Feature type

allele

Associated gene

Hsap\HNRNPA2B1

Associated Insertion(s)

Carried in Construct

P{UAS-HNRNPA2B1.S}

Key Links

Transgenic product class

cDNA

(Sofola et al., 2007)

wild_type

(Sofola et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Sofola et al., 2007)

wild_type

(Sofola et al., 2007)

Mutagen

in vitro construct

(Sofola et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-HNRNPA2B1.S}

Cytology

Description

UASt regulatory sequences drive expression of a full length Hsap\HNRNPA2B1 cDNA.

(Sofola et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\HNRNPA2B1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Sofola et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

Hsap\HNRNPA2B1^Scer\UAS.cSa suppresses neurodegeneration in the Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} eye expression model of fragile X-associated tremor/ataxia syndrome.

(Sofola et al., 2007)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Hsap\HNRNPA2B1^UAS.cSa, Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, non-suppressible by Hsap\CELF1^UAS.cdHa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Hsap\HNRNPA2B1^UAS.cSa, Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has abnormal neuroanatomy | adult stage phenotype, non-suppressible by Hsap\CELF1^UAS.cdHa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Suppressor of

Statement

Reference

Hsap\HNRNPA2B1^UAS.cSa, Scer\GAL4^GMR.PF is a suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP

(Sofola et al., 2007)

Hsap\HNRNPA2B1^UAS.cSa, Scer\GAL4^GMR.PF is a suppressor of abnormal neuroanatomy | adult stage phenotype of Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP

(Sofola et al., 2007)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Hsap\HNRNPA2B1^UAS.cSa, Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by Hsap\CELF1^UAS.cdHa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Hsap\HNRNPA2B1^UAS.cSa, Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, non-suppressible by Hsap\CELF1^UAS.cdHa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Suppressor of

Statement

Reference

Hsap\HNRNPA2B1^UAS.cSa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP

(Sofola et al., 2007)

Hsap\HNRNPA2B1^UAS.cSa, Scer\GAL4^GMR.PF is a suppressor of ommatidium phenotype of Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP

(Sofola et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\HNRNPA2B1^Scer\UAS.cSa suppresses the fused ommatidia phenotype seen when Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

Co-expression of Hsap\CELF1^{Scer\UAS.cdHa} does not prevent Hsap\HNRNPA2B1^Scer\UAS.cSa from suppressing the fused ommatidia phenotype seen when Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

(Sofola et al., 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\HNRNPA2B1^Scer\UAS.cSa

Hsap\HNRNPA2B1^UAS.cSa

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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