FlyBase Allele Report: Dmel\Drep2[ex13]

General Information

Symbol

Dmel\Drep2^ex13

Species

D. melanogaster

Name

FlyBase ID

FBal0300864

Feature type

allele

Associated gene

Dmel\Drep2

Associated Insertion(s)

Carried in Construct

Also Known As

drep-2^ex13

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

FLPase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Andlauer et al., 2014)

Mutagen

FLPase

(Andlauer et al., 2014)

Progenitor genotype

P{XP}Drep2^d00223

(Andlauer et al., 2014)

PBac{RB}Drep2^e04659

(Andlauer et al., 2014)

Cytology

Description

FLP-mediated excision between P{XP}Drep2^d00223 and PBac{RB}Drep2^e04659 has resulted in deletion of all of the Drep2 exons.

(Andlauer et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:9,292,666..9,300,349 [+]

Comment:

Scer\FRT-mediated recombination between the two progenitor insertions has resulted in the deletion of the genomic sequence between them.

(Andlauer et al., 2014)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Bhat et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning | recessive

(Andlauer et al., 2014)

abnormal memory | recessive

(Andlauer et al., 2014)

fertile

(Andlauer et al., 2014)

short lived

(Andlauer et al., 2014)

viable

(Andlauer et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Thes mutants are short lived compared to controls.

(Andlauer et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Drep2^ex13 has abnormal memory | recessive phenotype, non-enhanceable by mGluR^112b

(Andlauer et al., 2014)

Drep2^ex13 has abnormal learning | recessive phenotype, non-enhanceable by mGluR^112b

(Andlauer et al., 2014)

Suppressed by

Statement

Reference

Drep2^ex13 has abnormal memory | recessive phenotype, suppressible by Fmr1^B55/Fmr1[+]

(Andlauer et al., 2014)

Drep2^ex13 has abnormal learning | recessive phenotype, suppressible by Fmr1^B55/Fmr1[+]

(Andlauer et al., 2014)

NOT Enhancer of

Statement

Reference

Drep2^ex13 is a non-enhancer of abnormal memory | recessive phenotype of mGluR^112b

(Andlauer et al., 2014)

Drep2^ex13 is a non-enhancer of abnormal learning | recessive phenotype of mGluR^112b

(Andlauer et al., 2014)

Suppressor of

Statement

Reference

Drep2^ex13/Drep2^ex13 is a suppressor of abnormal memory | dominant phenotype of Fmr1^B55

(Andlauer et al., 2014)

Drep2^ex13/Drep2^ex13 is a suppressor of abnormal learning | dominant phenotype of Fmr1^B55

(Andlauer et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Drep2^ex13 mGluR^112b double mutants exhibit olfactory short term memory defects similar to those seen in either mutant alone.

In contrast to either mutant alone, Drep2^ex13/Drep2^ex13, Fmr1^B55/+ double mutants do not exhibit defects in olfactory short term memory.

(Andlauer et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Drep2^ex13 is rescued by Drep2^UAS.cAa/Scer\GAL4^elav.PLu

(Andlauer et al., 2014)

Drep2^ex13 is rescued by Drep2^UAS.cAa/Scer\GAL4^30Y

(Andlauer et al., 2014)

Drep2^ex13 is rescued by Scer\GAL4^Mef2.247/Drep2^UAS.cAa

(Andlauer et al., 2014)

Comments

Expression of Drep2^Scer\UAS.cAa either pan-neuronally (using Scer\GAL4^elav.PLu) or in Kenyon cells (using either Scer\GAL4^30Y or Scer\GAL4^Mef2.247) rescues the olfactory short term memory defects seen in Drep2^ex13 mutant flies. The intermediate olfactory memory defects can be rescued using either Scer\GAL4^elav.PLu or Scer\GAL4^Mef2.247.

(Andlauer et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Drep-2^ex13

(Bhat et al., 2021)

Drep2^ex13

drep-2^ex13

(Andlauer et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

Open Close