FlyBase Gene Report: Dmel\Drep2

General Information

Symbol

Dmel\Drep2

Species

D. melanogaster

Name

DNA fragmentation factor-related protein 2

Annotation Symbol

CG1975

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028408

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Summary

DNA fragmentation factor-related protein 2 (Drep2) encodes a protein involved in neuron death regulation. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Also Known As

Drep-2, Rep2

Key Links

Genomic Location

Cytogenetic map

45C4-45C5

Sequence location

2R:9,291,856..9,302,821 [+]

Recombination map

2-60

RefSeq locus

NT_033778 REGION:9291856..9302821

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

NOT enables nuclease activity

inferred from direct assay

(Andlauer et al., 2014)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in apoptotic process

inferred from electronic annotation with InterPro:IPR003508

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000959605

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in postsynaptic membrane

inferred from direct assay

(Andlauer et al., 2014)

located_in synaptic membrane

inferred from direct assay

(Andlauer et al., 2014)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

CIDE-N domain

Summaries

Gene Snapshot

DNA fragmentation factor-related protein 2 (Drep2) encodes a protein involved in neuron death regulation. [Date last reviewed: 2019-09-12]

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Drep2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A8DY77)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

4D2K

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Drep2-RA

FBtr0088597

NM_136634

5229

482

Drep2-RB

FBtr0112930

NM_001103768

5203

549

Drep2-RC

FBtr0304798

NM_001259293

5839

482

Drep2-RD

FBtr0332998

NM_001273891

1827

497

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Drep2-PA

FBpp0087678

51.9

482

5.10

FBpp0111843

57.8

549

5.27

FBpp0293338

51.9

482

5.10

FBpp0305213

53.6

497

5.27

A0A0B4KFF6

NP_001260820

AGB93353

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

482 aa isoforms: Drep2-PA, Drep2-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

CIDE-N domain

PDB - An information portal to biological macromolecular structures

4D2K

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Drep2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.59

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 17

larval central nervous system

(Andlauer et al., 2014)

wandering third instar larval stage

wing pouch | restricted

(Molnar et al., 2012)

wing hinge primordium | restricted

(Molnar et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

synaptic neuropil

(Andlauer et al., 2014)

larval brain

(Andlauer et al., 2014)

adult stage

synaptic neuropil

(Andlauer et al., 2014)

adult brain

(Andlauer et al., 2014)

calyx of adult mushroom body

(Andlauer et al., 2014)

adult optic lobe

(Andlauer et al., 2014)

adult antennal lobe

(Andlauer et al., 2014)

Kenyon cell

(Andlauer et al., 2014)

adult central complex

(Andlauer et al., 2014)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Drep2 is expressed throughout the synaptic neuropil in larval and adult brains. It is observed in the optic lobe, antennal lobe and central complex, but is particularly pronounced in the mushroom body calyx. Comparison to pre- and postsynaptic brain markers revealed that Drep2 accumulates at postsynaptic specializations of Kenyon cells within the mushroom body calyx.

(Andlauer et al., 2014)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in postsynaptic membrane

inferred from direct assay

(Andlauer et al., 2014)

located_in synaptic membrane

inferred from direct assay

(Andlauer et al., 2014)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Drep2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Drep2

View exonic expression by tissue for Dmel\Drep2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0028408

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35955/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028408

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028408

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028408

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1975

Flygut - An atlas of the Drosophila adult midgut

FBgn0028408

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 19 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Drep2

Transgenic constructs containing regulatory region of Drep2

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene partially disrupted in

Df(2R)Mad1¹

(Emre et al., 2011)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^insc-Mz1407

Drep2^GD9693

lethal - all die before end of larval stage, with Scer\GAL4^Cg.PU

Drep2^GD9693

lethal - all die before end of larval stage, with Scer\GAL4^Mef2.PU

Drep2^GD9693

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

Drep2^GD9693

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Drep2^GD9693

partially lethal - majority die | nutrition conditional, with Scer\GAL4^Ubi.PU

Drep2^GD9693

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Drep2^GD9693

viable, with Scer\GAL4^tin.CΔ4

Drep2^GD9693

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal learning (with Df(2R)w45-30n)

Drep2^ex27

abnormal learning | recessive

Drep2^ex13

abnormal memory (with Df(2R)w45-30n)

Drep2^ex27

abnormal memory | recessive

Drep2^ex13

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

Drep2^GD9693

abnormal starvation stress response | adult stage, with Scer\GAL4^NP0001

Drep2^GD9693

majority die during larval stage | nutrition conditional, with Scer\GAL4^Ubi.PU

Drep2^GD9693

short lived

short lived | calorie restriction conditional, with Scer\GAL4^NP0001

Drep2^GD9693

some die during pupal stage, with Scer\GAL4^pnr-MD237

Drep2^GD9693

visible, with Scer\GAL4^pnr-MD237

Drep2^GD9693

Phenotype manifest in

Allele

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

Drep2^GD9693

larval neuroblast | larval stage, with Scer\GAL4^insc-Mz1407

Drep2^GD9693

mesonotum, with Scer\GAL4^pnr-MD237

Drep2^GD9693

sarcomere, with Scer\GAL4^Mef2.PR

Drep2^GD9693

Z disc, with Scer\GAL4^Mef2.PR

Drep2^GD9693

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (5)

Hsap\CIDEC

5 of 14

Yes

4 of 14

4 of 14

2 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (5)

Rnor\Cidec

5 of 14

Yes

4 of 14

3 of 14

2 of 14

1 of 14

Mus musculus (laboratory mouse) (5)

Mmus\Cidec

5 of 14

Yes

4 of 14

4 of 14

2 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (6)

Xtro\cidea

4 of 13

Yes

Xtro\cideb

4 of 13

Yes

3 of 13

2 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (5)

Drer\cidea

5 of 14

Yes

Drer\cideb

4 of 14

Yes

Drer\cidec

4 of 14

Drer\dffa

4 of 14

Drer\dffb

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP005254

10 of 12

Yes

Agam\AgaP_AGAP009681

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Drep2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (3)

Drep1

4 of 13

Drep3

3 of 13

Drep4

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CIDEC; cell death inducing DFFA like effector c

model of familial partial lipodystrophy type 5

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

Drep2^KG02396

exacerbates neurodegenerative disease

modeled by Zzzz\CGG^90.UAS.EGFP

(Tan et al., 2012)

Drep2^d00223

ameliorates neurodegenerative disease

modeled by Zzzz\CGG^90.UAS.EGFP

(Tan et al., 2012)

Drep2^ex13

ameliorates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Bhat et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CIDEC; cell death inducing DFFA like effector c

5 of 14

612120

LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 5; FPLD5

familial partial lipodystrophy type 5

CIDEA; cell death inducing DFFA like effector a

4 of 14

604440

CIDEB; cell death inducing DFFA like effector b

4 of 14

604441

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Drep2

molecular sieving, predetermined participant, molecular weight estimation by staining, light scattering, molecular weight, x-ray crystallography, dynamic light scattering

(Ha and Park, 2022, Ha and Park, 2018, Kim et al., 2017, Lee and Park, 2014, Lee and Park, 2013, Park and Park, 2013, Park and Park, 2012)

Drep2 - AGO2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - CG14095

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - CG15701

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - CG17127

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - CG17271

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - CG30122

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - CG7903

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - Capr

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - Cdep

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - Con

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - Cpr65Av

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - Drep1

comigration in non denaturing gel electrophoresis, molecular weight estimation by staining, anti tag coimmunoprecipitation, anti tag western blot, molecular sieving, molecular weight, predetermined participant

(Kim et al., 2017, Lee and Park, 2014, Lee and Park, 2013, Park and Park, 2013, Inohara and Nunez, 1999)

Drep2 - Drep3

comigration in non denaturing gel electrophoresis, molecular weight estimation by staining, molecular sieving, anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot, molecular weight, pull down

(Kim et al., 2017, Andlauer et al., 2014, Lee and Park, 2014, Lee and Park, 2013, Park and Park, 2012, Inohara and Nunez, 1999)

Drep2 - Fmr1

anti tag coimmunoprecipitation, western blot

(Andlauer et al., 2014)

Drep2 - His3

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - Lcp65Ad

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - Moca-cyp

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - NAT1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - Nup43

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - Rab3-GEF

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - RnpS1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - SF1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - Saf-B

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - Syt7

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - Zasp52

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - cos

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - crb

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - frm

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - htl

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - mbo

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - mfrn

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - mld

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - nolo

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - sif

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - snf

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - teq

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Drep2 - tyn

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

RNA-RNA

Physical Interaction

Assay

References

Drep2 - mir-277

luminiscence technology, necessary binding region, quantitative reverse transcription pcr

(Tan et al., 2012)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Drep2

suppressible

Fmr1

(Andlauer et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Fmr1

suppressible

Drep2

(Andlauer et al., 2014)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

61791

DroID - A comprehensive database of gene and protein interactions.

FBgn0028408

MIST (protein-protein) - An integrated Molecular Interaction Database

35955

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Lipid particle organization

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Lipid particle organization

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-60

Cytogenetic map

45C4-45C5

Sequence location

2R:9,291,856..9,302,821 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

45C4-45C5

Limits computationally determined from genome sequence between P{lacW}Pkn^k11209 and P{lacW}wun^k09507&P{lacW}l(2)k12402^k12402

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-60

(FlyBase, 2016)

2-58.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

43466

w^*; P{GSV1}Drep2^EP-M89

61921

y¹ v¹; P{TRiP.HMJ23477}attP40

81737

y¹ v¹; P{TKO.GS04674}attP40/CyO

20727

y¹ w^67c23; P{EPgy2}Drep2^EY12060

13312

y¹ w^67c23; P{SUPor-P}Drep2^KG02396

NIG-Fly

HMJ23477

y¹ v¹; P{TRiP.HMJ23477}attP40/CyO

VDRC

v20771

w¹¹¹⁸; P{GD9693}v20771

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (47)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD32009

Other clones

FI14507

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0028408

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0028408

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Andlauer et al., 2014)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Area matching Drosophila EST AA441346. This EST forms a 1677bp contig with ESTs AA390646 and AA696470.

(Davies, 2001.3.15)

Area matching Drosophila EST AA390646. This EST forms a 1705bp contig with ESTs AA440523 and AA696470.

(Davies, 2001.3.15)

Relationship to Other Genes

Source for database merge of

Source for merge of: Rep2 anon-WO0118547.162 anon-WO0118547.168

(FlyBase, 1996-)

Additional comments

Source for merge of Rep2 anon-WO0118547.162 anon-WO0118547.168 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Drep2 Drep-2

(FlyBase, 2009-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG1975

(Hosono et al., 2015, Azad et al., 2012, Perkins et al., 2009, Molnar et al., 2006)

DREP-2

(Inohara and Nunez, 1999)

DREP2

(Ha and Park, 2022, Ha and Park, 2018, Kim et al., 2017)

Drep-2

(Havula et al., 2022, Bhat et al., 2021, Aradska et al., 2015, Andlauer et al., 2014, de Celis et al., 2013.9.11, Tan et al., 2012)

Drep2

(Pooryasin et al., 2021, Kurmangaliyev et al., 2020, Tenedini et al., 2019, Choi et al., 2017, Transgenic RNAi Project members, 2017-, Carbone et al., 2016, Lee and Park, 2014, Lee and Park, 2014, Lee and Park, 2013, Park and Park, 2013, Park and Park, 2012, Tan et al., 2012, Park and Park, 2011)

Rep2

(Azad et al., 2012, FlyBase Curators, 2008-, Molnar et al., 2006)

anon-WO0118547.162

anon-WO0118547.168

drep2

(Inohara, 1999.5.10)

rep2

(Emre et al., 2011)

Name Synonyms

DNA fragmentation factor-related protein 2

(Andlauer et al., 2014, Tan et al., 2012)

Rep2

Secondary FlyBase IDs

FBgn0062196
FBgn0062202

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 72 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35955

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A8DY77

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A8DY77

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0028408

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35955/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028408

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028408

FlyMine - An integrated database for Drosophila genomics

FBgn0028408

InterPro - A database of protein families, domains and functional sites

CIDE-N domain

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1975

MARRVEL_MODEL - MARRVEL (model organism gene)

35955

PDB - An information portal to biological macromolecular structures

4D2K

Linkouts

BioGRID - A database of protein and genetic interactions.

61791

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0028408

DroID - A comprehensive database of gene and protein interactions.

FBgn0028408

DRSC - Results frm RNAi screens

FBgn0028408

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028408

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0028408

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1975

Flygut - An atlas of the Drosophila adult midgut

FBgn0028408

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0028408

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC011893

MIST (protein-protein) - An integrated Molecular Interaction Database

35955

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Lipid particle organization

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Lipid particle organization

References (61)

The following external sites may use different assemblies or annotations than FlyBase.

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