FlyBase Allele Report: Dmel\Pkc53E[HMC04134]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\Pkc53E^HMC04134

General Information

Symbol

Dmel\Pkc53E^HMC04134

Species

D. melanogaster

Name

FlyBase ID

FBal0299183

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC04134}

Also Known As

UAS-Pkc53E RNAi

Key Links

Genomic Maps

Transgenic product class

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMC04134}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Also carries

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates amyotrophic lateral sclerosis type 10

modeled by TBPH^{UAS.Tag:FLAG.Tag:HA}

(Park et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

actin cytoskeleton | adult stage, with Scer\GAL4^GMR.PF

(Shieh et al., 2023)

ommatidium | adult stage, with Scer\GAL4^GMR.PF

(Shieh et al., 2023)

rhabdomere | adult stage | decreased number, with Scer\GAL4^GMR.PF

(Shieh et al., 2023)

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Pkc53E^HMC04134, Scer\GAL4^GMR.PF has rhabdomere | adult stage | decreased number phenotype, enhanceable by norpA^P24

(Shieh et al., 2023)

Enhancer of

Statement

Reference

Pkc53E^HMC04134/Scer\GAL4^GMR.PF is an enhancer of rhabdomere | adult stage phenotype of norpA^P24

(Shieh et al., 2023)

Pkc53E^HMC04134/Scer\GAL4^GMR.PF is an enhancer of eye photoreceptor cell | adult stage phenotype of norpA^P24

(Shieh et al., 2023)

NOT Enhancer of

Statement

Reference

Pkc53E^HMC04134, Scer\GAL4^GMR.PF is a non-enhancer of eye photoreceptor cell | adult stage phenotype of CG30054^HMJ30300, Scer\GAL4^GMR.PF

(Shieh et al., 2023)

NOT Suppressor of

Statement

Reference

Pkc53E^HMC04134, Scer\GAL4^GMR.PF is a non-suppressor of eye photoreceptor cell | adult stage phenotype of CG30054^HMJ30300, Scer\GAL4^GMR.PF

(Shieh et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

55864

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04134}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Pkc53E^HMC04134

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections