FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Ubqn
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General Information
Symbol
Dmel\Ubqn
Species
D. melanogaster
Name
Ubiquilin
Annotation Symbol
CG14224
Feature Type
protein_coding_gene
FlyBase ID
FBgn0031057
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Summary
Ubiquilin (Ubqn) encodes a protein containing an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. It binds and delivers ubiquitinated, misfolded or no longer functionally required proteins to the ubiquitin-proteasome system and/or autophagy. [Date last reviewed: 2018-10-04] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Dsk2, dUbqn, dUbqln

Key Links
Genomic Location
Cytogenetic map
18E1-18E1
Sequence location
Recombination map
1-64
RefSeq locus
NC_004354 REGION:19683808..19687658
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables proteasome binding
inferred from physical interaction with FLYBASE:Rpn10; FB:FBgn0015283
(Lipinszki et al., 2011)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables polyubiquitin modification-dependent protein binding
inferred from biological aspect of ancestor with PANTHER:PTN000073411
(GO Reference Genome Project, 2011-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in amyloid precursor protein metabolic process
inferred from mutant phenotype
(Li et al., 2007)
involved_in ubiquitin-dependent protein catabolic process
inferred from mutant phenotype
(Jantrapirom et al., 2018)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in ubiquitin-dependent protein catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000073411
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000073411
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Ubiquilin (Ubqn) encodes a protein containing an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. It binds and delivers ubiquitinated, misfolded or no longer functionally required proteins to the ubiquitin-proteasome system and/or autophagy. [Date last reviewed: 2018-10-04]
Summary (Interactive Fly)

extraproteasomal ubiquitin receptor that targets ubiquitylated proteins for degradation - interacts with the dHP1c complex, localizes at promoters of developmental genes and is required for transcription - interacts with monoubiquitylated H2B - regulation of postsynaptic growth at the NMJ - binds and delivers ubiquitinated misfolded or no longer functionally required proteins to the ubiquitin-proteasome system

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Ubqn for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VWD9)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ubqn-RA
FBtr0074750
NM_134500
3011
547
Ubqn-RB
FBtr0340612
NM_001298528
3429
547
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Ubqn-PA
FBpp0074519
58.8
547
4.72
Q9VWD9
NP_608344
AAF49003
Ubqn-PB
FBpp0309477
58.8
547
4.72
Q9VWD9
NP_001285457
AHN59927
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

547 aa isoforms: Ubqn-PA, Ubqn-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ubqn using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.37

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
organism
(Lipinszki et al., 2009)
Additional Descriptive Data

Expression of Ubqn protein is lowest during first, second and early third instar larval stages.

(Lipinszki et al., 2009)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
Expression Deduced from Reporters
Reporter: PBac{Ubqn-GFP.fTRG}
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
larval nervous system
(Şentürk et al., 2019)
organism | ubiquitous
(Şentürk et al., 2019)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ubqn in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 20 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ubqn
Transgenic constructs containing regulatory region of Ubqn
Aberrations (Deficiencies and Duplications) ( 1 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4da.G32
lethal, with Scer\GAL4Tub.PU
lethal | pharate adult stage P14, with Scer\GAL4da.G32
lethal | pharate adult stage P15, with Scer\GAL4da.G32
lethal - all die before end of prepupal stage
lethal - all die before end of prepupal stage | female (with Df(1)BSC871)
lethal - all die before end of prepupal stage | female (with Ubqn1)
lethal - all die before end of prepupal stage | female (with UbqnΔCDS)
lethal - all die before end of prepupal stage | male
lethal - all die before end of P-stage, with Scer\GAL4da.G32
partially lethal - majority die | male limited, with Scer\GAL4sd-SG29.1
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal courtship behavior, with Scer\GAL4elav.PU
abnormal locomotor behavior | adult stage, with Scer\GAL4elav.PLu
abnormal locomotor behavior | adult stage, with Scer\GAL4Toll-6-D42
abnormal locomotor behavior | third instar larval stage, with Scer\GAL4elav.PLu
abnormal locomotor behavior | third instar larval stage, with Scer\GAL4Toll-6-D42
abnormal memory | adult stage, with Scer\GAL4elav.PLu
abnormal neuroanatomy, with Scer\GAL4GMR.PF
abnormal neuroanatomy | adult stage | progressive | somatic clone
abnormal neuroanatomy | male limited, with Scer\GAL4elav-C155
abnormal neuroanatomy | prepupal stage P4
abnormal neurophysiology | adult stage | progressive
abnormal size | adult stage | progressive | somatic clone
abnormal size | prepupal stage P4
abnormal size | third instar larval stage, with Scer\GAL4elav.PLu
abnormal smell perception | adult stage, with Scer\GAL4elav.PLu
decreased cell number | adult stage | progressive | somatic clone
decreased fecundity | female | germline clone
decreased rate of movement | adult stage, with Scer\GAL4elav.PU
flightless, with Scer\GAL4Mef2.PR
increased cell death | adult stage | progressive | somatic clone
increased cell death | male limited, with Scer\GAL4elav-C155
short lived, with Scer\GAL4elav.PLu
short lived | male limited, with Scer\GAL4elav-C155
some die during pharate adult stage, with Scer\GAL4da.G32
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
adult subretinal glial cell | adult stage | progressive | somatic clone
air bubble | pharate adult stage, with Scer\GAL4da.G32
amphisome | adult stage | somatic clone
anterior crossvein, with Scer\GAL4e22c
anterior crossvein, with Scer\GAL4ptc-559.1
anterior crossvein, with Scer\GAL4sd-SG29.1
autolysosome | adult stage | somatic clone
autolysosome | somatic clone | third instar larval stage
autophagosome | adult stage | somatic clone
autophagosome | somatic clone | third instar larval stage
crossvein, with Scer\GAL4Bx-MS1096
dorsal appendage
egg
embryonic/larval fat body | second instar larval stage | somatic clone
embryonic/larval fat body | somatic clone | third instar larval stage
embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4elav.PU
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4elav.PLu
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4Toll-6-D42
embryonic/larval salivary gland | somatic clone | third instar larval stage
endoplasmic reticulum | adult stage | somatic clone
endoplasmic reticulum | somatic clone | third instar larval stage
eye, with Scer\GAL4elav.PLu
eye, with Scer\GAL4GMR.PS
eye | pharate adult stage, with Scer\GAL4da.G32
eye photoreceptor cell, with Scer\GAL4GMR.PF
eye photoreceptor cell | adult stage | progressive | somatic clone
fat body | prepupal stage P4
head | pharate adult stage, with Scer\GAL4da.G32
head | prepupal stage P4
indirect flight muscle cell, with Scer\GAL4Mef2.PR
lamina | adult stage | progressive | somatic clone
larval brain | third instar larval stage, with Scer\GAL4elav.PLu
leg | pharate adult stage, with Scer\GAL4da.G32
lysosome | adult stage | somatic clone
lysosome | second instar larval stage | somatic clone
lysosome | somatic clone | third instar larval stage
mesonotum, with Scer\GAL4pnr-MD237
midgut | prepupal stage P4
mitochondrion | adult stage | progressive | somatic clone
mushroom body | third instar larval stage, with Scer\GAL4elav.PLu
myofibril, with Scer\GAL4Mef2.PR
neuropil, with Scer\GAL4elav-C155
neuropil | prepupal stage P4
NMJ bouton | decreased number | larval stage, with Scer\GAL4elav.PU
NMJ bouton | third instar larval stage, with Scer\GAL4elav.PLu
NMJ bouton | third instar larval stage, with Scer\GAL4Toll-6-D42
pigment cell, with Scer\GAL4GMR.PF
posterior crossvein, with Scer\GAL4e22c
posterior crossvein, with Scer\GAL4sd-SG29.1
retina | adult stage | progressive
retina | adult stage | progressive | somatic clone
retina | adult stage | somatic clone
rhabdomere of eye photoreceptor cell | adult stage | progressive | somatic clone
synapse, with Scer\GAL4elav.PU
trichogen cell, with Scer\GAL4pnr-MD237
vacuole | somatic clone | third instar larval stage
wing, with Scer\GAL4Bx-MS1096
wing | pharate adult stage, with Scer\GAL4da.G32
wing cell, with Scer\GAL4ptc-559.1
wing margin, with Scer\GAL4sd-SG29.1
wing vein | ectopic, with Scer\GAL4e22c
wing vein | ectopic, with Scer\GAL4sd-SG29.1
wing vein L3, with Scer\GAL4Bx-MS1096
wing vein L3, with Scer\GAL4e22c
wing vein L3, with Scer\GAL4sd-SG29.1
wing vein L4, with Scer\GAL4Bx-MS1096
wing vein L4, with Scer\GAL4e22c
wing vein L4, with Scer\GAL4sd-SG29.1
wing vein L5, with Scer\GAL4Bx-MS1096
wing vein L5, with Scer\GAL4e22c
wing vein L5, with Scer\GAL4sd-SG29.1
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (20)
Hsap\UBQLN1
14 of 14
Yes
Yes
5  
Hsap\UBQLN2
12 of 14
No
Yes
8  
Hsap\UBQLN4
12 of 14
No
Yes
Hsap\UBQLN3
6 of 14
No
Yes
Hsap\UBQLNL
4 of 14
No
No
Hsap\BAG6
1 of 14
No
No
Hsap\DDI1
1 of 14
No
No
1  
Hsap\FAU
1 of 14
No
No
Hsap\NEDD8
1 of 14
No
No
Hsap\NEDD8-MDP1
1 of 14
No
Yes
Hsap\OASL
1 of 14
No
Yes
Hsap\RAD23A
1 of 14
No
No
1  
Hsap\RAD23B
1 of 14
No
No
Hsap\RPS27A
1 of 14
No
No
Hsap\UBB
1 of 14
No
No
4  
Hsap\UBD
1 of 14
No
No
Hsap\UBL4A
1 of 14
No
No
1  
Hsap\UBL4B
1 of 14
No
No
1  
Hsap\UBL7
1 of 14
No
No
1  
Hsap\ZFAND4
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (25)
Rnor\Ubqln1
14 of 14
Yes
Yes
Rnor\Ubqln4
12 of 14
No
Yes
Rnor\Ubqln2
11 of 14
No
Yes
Rnor\Ubqln3
6 of 14
No
Yes
Rnor\RGD1562433
4 of 14
No
No
Rnor\Ubqlnl
4 of 14
No
No
Rnor\Ubl7
2 of 14
No
No
Rnor\Fau
1 of 14
No
No
Rnor\Isg15
1 of 14
No
Yes
Rnor\LOC679594
1 of 14
No
Yes
Rnor\LOC687780
1 of 14
No
No
Rnor\Nedd8
1 of 14
No
No
Rnor\Oas1a
1 of 14
No
Yes
Rnor\Oas1b
1 of 14
No
Yes
Rnor\Oas1d
1 of 14
No
Yes
Rnor\Oas1e
1 of 14
No
Yes
Rnor\Oas1i
1 of 14
No
Yes
Rnor\Oasl2
1 of 14
No
Yes
Rnor\Oasl
1 of 14
No
Yes
Rnor\Prkn
1 of 14
No
No
Rnor\Rad23a
1 of 14
No
No
Rnor\Rad23b
1 of 14
No
No
Rnor\Rps27a
1 of 14
No
No
Rnor\Ubd
1 of 14
No
No
Rnor\Zfand4
1 of 14
No
No
Mus musculus (laboratory mouse) (28)
Mmus\Ubqln1
14 of 14
Yes
Yes
Mmus\Ubqln2
11 of 14
No
Yes
Mmus\Ubqln4
11 of 14
No
Yes
Mmus\Ubqln3
6 of 14
No
Yes
Mmus\Ubqln5
4 of 14
No
No
Mmus\Ubqlnl
4 of 14
No
No
Mmus\Ubl7
2 of 14
No
No
Mmus\Bag6
1 of 14
No
No
Mmus\Fau
1 of 14
No
No
Mmus\Isg15
1 of 14
No
Yes
Mmus\Nedd8
1 of 14
No
No
Mmus\Oas1a
1 of 14
No
Yes
Mmus\Oas1c
1 of 14
No
Yes
Mmus\Oas1d
1 of 14
No
Yes
Mmus\Oas1e
1 of 14
No
Yes
Mmus\Oas1f
1 of 14
No
Yes
Mmus\Oas1g
1 of 14
No
Yes
Mmus\Oas1h
1 of 14
No
Yes
Mmus\Oasl1
1 of 14
No
Yes
Mmus\Oasl2
1 of 14
No
Yes
Mmus\Rad23a
1 of 14
No
No
Mmus\Rad23b
1 of 14
No
No
Mmus\Rps27a
1 of 14
No
No
Mmus\Ubb
1 of 14
No
No
Mmus\Ubc
1 of 14
No
No
Mmus\Ubd
1 of 14
No
No
Mmus\Ubl4a
1 of 14
No
No
Mmus\Ubl4b
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (7)
Xtro\ubqln1
11 of 13
Yes
Yes
Xtro\ubqln4
10 of 13
No
Yes
Xtro\ccno
1 of 13
No
Yes
Xtro\clta
1 of 13
No
No
Xtro\dnajc15
1 of 13
No
No
Xtro\erich1
1 of 13
No
No
Xtro\ubl7
1 of 13
No
No
Danio rerio (Zebrafish) (9)
Drer\ubqln4
12 of 14
Yes
Yes
Drer\ubl7a
2 of 14
No
No
Drer\ubl7b
2 of 14
No
No
Drer\faub
1 of 14
No
No
Drer\isg15
1 of 14
No
No
Drer\nedd8
1 of 14
No
No
Drer\rad23ab
1 of 14
No
No
Drer\zfand4
1 of 14
No
No
Drer\zgc:56596
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (16)
Cele\ubql-1
12 of 14
Yes
Yes
Cele\C16C8.4
1 of 14
No
No
Cele\C16C8.5
1 of 14
No
Yes
Cele\C16C8.11
1 of 14
No
No
Cele\C16C8.13
1 of 14
No
Yes
Cele\C16C8.14
1 of 14
No
Yes
Cele\F14D2.11
1 of 14
No
No
Cele\F34H10.1
1 of 14
No
No
Cele\F49C12.9
1 of 14
No
Yes
Cele\F52C6.2
1 of 14
No
No
Cele\F52C6.3
1 of 14
No
No
Cele\F52C6.4
1 of 14
No
No
Cele\K08C9.7
1 of 14
No
No
Cele\ned-8
1 of 14
No
No
Cele\rad-23
1 of 14
No
No
Cele\rps-30
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (10)
Agam\AgaP_AGAP004294
12 of 12
Yes
Yes
Agam\AgaP_AGAP004245
3 of 12
No
No
Agam\AgaP_AGAP000733
1 of 12
No
No
Agam\AgaP_AGAP001757
1 of 12
No
No
Agam\AgaP_AGAP001969
1 of 12
No
No
Agam\AgaP_AGAP001970
1 of 12
No
No
Agam\AgaP_AGAP001971
1 of 12
No
No
Agam\AgaP_AGAP002389
1 of 12
No
No
Agam\AgaP_AGAP002599
1 of 12
No
No
Agam\AgaP_AGAP007913
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (45)
Atha\AT2G17190
12 of 13
Yes
Yes
Atha\DSK2
12 of 13
Yes
Yes
Atha\AT1G11970
1 of 13
No
No
Atha\AT1G23410
1 of 13
No
No
Atha\AT1G31335
1 of 13
No
Yes
Atha\AT1G53930
1 of 13
No
No
Atha\AT1G53950
1 of 13
No
No
Atha\AT1G53980
1 of 13
No
No
Atha\AT2G32350
1 of 13
No
No
Atha\AT3G06455
1 of 13
No
No
Atha\AT4G01000
1 of 13
No
No
Atha\AT4G02950
1 of 13
No
Yes
Atha\AT4G03360
1 of 13
No
No
Atha\AT4G03370
1 of 13
No
No
Atha\AT4G05230
1 of 13
No
No
Atha\AT4G05240
1 of 13
No
No
Atha\AT4G05250
1 of 13
No
No
Atha\AT4G05260
1 of 13
No
No
Atha\AT4G05270
1 of 13
No
No
Atha\AT4G05310
1 of 13
No
No
Atha\AT5G09340
1 of 13
No
No
Atha\AT5G16090
1 of 13
No
No
Atha\AT5G24240
1 of 13
No
No
Atha\AT5G25270
1 of 13
No
No
Atha\AT7SL-1
1 of 13
No
No
Atha\EVE1
1 of 13
No
No
Atha\PI4K GAMMA 4
1 of 13
No
No
Atha\RAD23A
1 of 13
No
No
Atha\RAD23B
1 of 13
No
No
Atha\RAD23C
1 of 13
No
No
Atha\RAD23D
1 of 13
No
No
Atha\RUB1
1 of 13
No
No
Atha\RUB3
1 of 13
No
No
Atha\UBQ3
1 of 13
No
No
Atha\UBQ4
1 of 13
No
No
Atha\UBQ5
1 of 13
No
No
Atha\UBQ6
1 of 13
No
No
Atha\UBQ7
1 of 13
No
No
Atha\UBQ8
1 of 13
No
No
Atha\UBQ9
1 of 13
No
No
Atha\UBQ10
1 of 13
No
No
Atha\UBQ11
1 of 13
No
No
Atha\UBQ12
1 of 13
No
No
Atha\UBQ13
1 of 13
No
No
Atha\UBQ14
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (6)
Scer\DSK2
8 of 13
Yes
Yes
Scer\MDY2
1 of 13
No
No
Scer\RAD23
1 of 13
No
No
Scer\RPS31
1 of 13
No
No
Scer\RUB1
1 of 13
No
No
Scer\UBI4
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (7)
Spom\dph1
8 of 12
Yes
Yes
Spom\SPBC1E8.02
2 of 12
No
No
Spom\ned8
1 of 12
No
No
Spom\rhp23
1 of 12
No
No
Spom\SPAC589.10c
1 of 12
No
No
Spom\ubi3
1 of 12
No
No
Spom\ubi4
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Ubqn. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (10)
CG31528
7 of 13
CG3223
2 of 13
CG10694
2 of 13
CG7215
1 of 13
CG11700
1 of 13
Nedd8
1 of 13
Rad23
1 of 13
RpS27A
1 of 13
Ubi-p5E
1 of 13
Ubi-p63E
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
UBQLN2; ubiquilin 2
model of  amyotrophic lateral sclerosis type 15
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 6 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
UBQLN1; ubiquilin 1
14 of 14
605046
       
      UBQLN2; ubiquilin 2
      12 of 14
      UBIQUILIN 2; UBQLN2
       
      UBQLN4; ubiquilin 4
      12 of 14
      605440
          UBQLN3; ubiquilin 3
          6 of 14
          605473
              UBQLNL; ubiquilin like
              4 of 14
                  Functional Complementation Data
                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                  Interactions
                  Summary of Physical Interactions
                  Interaction Browsers
                  View in FlyBase Interactions Browser   View in MIST tool (external link)
                  Please see the Physical Interaction reports below for full details
                  protein-protein
                  Physical Interaction
                  Assay
                  References
                  Ubqn - CG30031
                  enzymatic study, western blot
                  (Lipinszki et al., 2013)
                  Ubqn - Cen
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  Ubqn - Fgop2
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  Ubqn - HP1b
                  anti bait coimmunoprecipitation, western blot, cosedimentation
                  (Kessler et al., 2015)
                  Ubqn - HP1c
                  cosedimentation, western blot, anti bait coimmunoprecipitation
                  (Kessler et al., 2015)
                  Ubqn - Prosα7
                  affinity chromatography technology, molecular sieving, western blot
                  (Lipinszki et al., 2012)
                  Ubqn - Psn
                  pull down, anti tag western blot
                  (Ganguly et al., 2008)
                  Ubqn - RluA-2
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  Ubqn - Rpn10
                  pull down, western blot, affinity chromatography technology, molecular sieving, cosedimentation, anti tag western blot
                  (Kessler et al., 2015, Lipinszki et al., 2012, Lipinszki et al., 2011)
                  Ubqn - Rpn7
                  affinity chromatography technology, molecular sieving, western blot
                  (Lipinszki et al., 2012)
                  Ubqn - Rpn9
                  affinity chromatography technology, molecular sieving, western blot
                  (Lipinszki et al., 2012)
                  Ubqn - Rpt3
                  affinity chromatography technology, molecular sieving, western blot
                  (Lipinszki et al., 2012)
                  Ubqn - Slmap
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  Ubqn - TBPH
                  anti bait coimmunoprecipitation, western blot
                  (Jantrapirom et al., 2018)
                  Ubqn - Tlk
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  Ubqn - ana2
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  Ubqn - cmet
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  Ubqn - dup
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  Ubqn - geminin
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  Ubqn - nxf2
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  Ubqn - row
                  cosedimentation, western blot, anti bait coimmunoprecipitation, experimental knowledge based
                  (Kessler et al., 2015, Guruharsha et al., 2011)
                  Ubqn - tim
                  anti tag coimmunoprecipitation, western blot
                  (Szabó et al., 2018)
                  Ubqn - woc
                  experimental knowledge based, anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation
                  (Di Mauro et al., 2020, Kessler et al., 2015, Guruharsha et al., 2011)
                  Ubqn - γTry
                  enzymatic study, western blot
                  (Lipinszki et al., 2013)
                  Ubqn - δTry
                  enzymatic study, western blot
                  (Lipinszki et al., 2013)
                  Summary of Genetic Interactions
                  Interaction Browsers
                  View in FlyBase Interactions Browser   View in MIST tool (external link)
                  Please look at the allele data for full details of the genetic interactions
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  Ubqn
                  suppressible
                  ATP6AP2
                  (Şentürk et al., 2019)
                  Ubqn
                  suppressible
                  Diap1
                  (Ganguly et al., 2008)
                  Ubqn
                  enhanceable
                  Psn
                  (Ganguly et al., 2008)
                  Ubqn
                  suppressible
                  Psn
                  (Ganguly et al., 2008)
                  Ubqn
                  suppressible
                  rho
                  (Li et al., 2007)
                  Ubqn
                  suppressible
                  Rpn10
                  (Lipinszki et al., 2011)
                  Ubqn
                  suppressible
                  TBPH
                  (Jantrapirom et al., 2018)
                  Ubqn
                  enhanceable
                  TBPH
                  (Jantrapirom et al., 2018)
                  Ubqn
                  suppressible
                  TER94
                  (Jantrapirom et al., 2018)
                  Ubqn
                  enhanceable
                  Vha68-2
                  (Şentürk et al., 2019)
                  Ubqn
                  suppressible
                  Vha100-1
                  (Şentürk et al., 2019)
                  Ubqn
                  enhanceable
                  VhaSFD
                  (Şentürk et al., 2019)
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  Psn
                  suppressible
                  Ubqn
                  (Ganguly et al., 2008, Li et al., 2007)
                  Psn
                  enhanceable
                  Ubqn
                  (Li et al., 2007)
                  TBPH
                  enhanceable
                  Ubqn
                  (Jantrapirom et al., 2018)
                  External Data
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Pathways
                  Signaling Pathways (FlyBase)
                  Metabolic Pathways
                  FlyBase
                  External Links
                  External Data
                  Linkouts
                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Class of Gene
                  Genomic Location and Detailed Mapping Data
                  Chromosome (arm)
                  X
                  Recombination map
                  1-64
                  Cytogenetic map
                  18E1-18E1
                  Sequence location
                  FlyBase Computed Cytological Location
                  Cytogenetic map
                  Evidence for location
                  18E1-18E1
                  Limits computationally determined from genome sequence between P{EP}Sec61γEP1511 and P{EP}EP1116&P{EP}EP1344EP1344
                  Experimentally Determined Cytological Location
                  Cytogenetic map
                  Notes
                  References
                  Experimentally Determined Recombination Data
                  Location

                  1-64

                  (FlyBase, 2016)

                  1-62.4

                  (Comeron et al., 2012)
                  Left of (cM)
                  Right of (cM)
                  Notes
                  Stocks and Reagents
                  Stocks (15)
                  Genomic Clones (10)
                   

                  Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                  cDNA Clones (105)
                   

                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                  cDNA clones, fully sequenced
                  BDGP DGC clones
                  Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                    cDNA Clones, End Sequenced (ESTs)
                    BDGP DGC clones
                    Other clones
                    RNAi and Array Information
                    Linkouts
                    DRSC - Results frm RNAi screens
                    Antibody Information
                    Laboratory Generated Antibodies
                     

                    polyclonal

                    (Jantrapirom et al., 2018, Li et al., 2007)
                    Commercially Available Antibodies
                     
                    Cell Line Information
                    Publicly Available Cell Lines
                     
                      Other Stable Cell Lines
                       
                        Other Comments

                        Not known to correspond to any of the known lethal complementation groups in 18D-18E region.

                        (Fehon, 1997.3.25)
                        Relationship to Other Genes
                        Source for database merge of

                        Source for merge of: CG14224 anon-18DEa

                        (Bayraktaroglu, 2000.11.2)

                        Source for merge of: CG14224 BEST:LD26923

                        (Rana, 2004.7.8)
                        Additional comments

                        FlyBase curator comment: Correspondence with author Guo revealed that 'Ubqn' = 'CG14224'.

                        (Guo et al., 2008)

                        FlyBase curator comment: Correspondence with author Li revealed that 'dUbqln' = 'CG14224'.

                        (Li et al., 2008)
                        Nomenclature History
                        Source for database identify of

                        Source for identity of: Ubqn CG14224

                        (Ganguly et al., 2008)
                        Nomenclature comments
                        Etymology
                        Synonyms and Secondary IDs (18)
                        Reported As
                        Symbol Synonym
                        BEST:LD26923
                        CG14224
                        (Çiçek et al., 2016, Japanese National Institute of Genetics, 2012.5.21, Sakata et al., 2012, Lipinszki et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Chen et al., 2008, Ganguly et al., 2008, Li et al., 2007, Dorer et al., 2006, Lawniczak and Begun, 2004)
                        Chap
                        (Demontis and Perrimon, 2010)
                        DSK2
                        (Dorer et al., 2006)
                        Dsk2
                        (Di Mauro et al., 2020, Lipinszki et al., 2013, Lipinszki et al., 2012, Lipinszki et al., 2011, Lipinszki et al., 2009)
                        UBQLN
                        (Yu and Hyun, 2021)
                        UBQLN homolog
                        (Hanson et al., 2010)
                        UBQLN1
                        (Gross et al., 2008)
                        Ubqn
                        (Gupta and Stocker, 2020, Jantrapirom et al., 2019, Liaw and Chiang, 2019, Şentürk et al., 2019, Azuma et al., 2018, Li-Kroeger et al., 2018, Wang et al., 2017, Appocher et al., 2014, Jalvingh et al., 2014, Marín, 2014, Kwon et al., 2013, Antao et al., 2012, Gross et al., 2008, Guo et al., 2008, Li et al., 2007)
                        anon-18DEa
                        clone 5.42
                        (Fehon et al., 1997)
                        dUbqln
                        (Kim et al., 2023, Marín, 2014, Li et al., 2008, Li et al., 2007)
                        dUbqn
                        (Yamaguchi et al., 2021, Jantrapirom et al., 2020, Phokasem et al., 2020, Lipinszki et al., 2011)
                        dsk2
                        (Kessler et al., 2015)
                        ubqn
                        (Zhang et al., 2018, Ganguly et al., 2008, Gross et al., 2008)
                        Name Synonyms
                        CG14224
                        Ubiquilin
                        (Zhang et al., 2022, Rincon-Limas et al., 2012, Sakata et al., 2012, Abel et al., 2009, Guo et al., 2008)
                        ubiquilin
                        (Casci and Pandey, 2015, Blount et al., 2014, Marín, 2014, Ganguly et al., 2008, Gross et al., 2008, Li et al., 2007)
                        ubiquilin 1
                        (Li et al., 2007)
                        Secondary FlyBase IDs
                        • FBgn0019902
                        • FBgn0045787
                        Datasets (0)
                        Study focus (0)
                        Experimental Role
                        Project
                        Project Type
                        Title
                        Study result (0)
                        Result
                        Result Type
                        Title
                        External Crossreferences and Linkouts ( 49 )
                        Sequence Crossreferences
                        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                        Other crossreferences
                        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                        FlyMine - An integrated database for Drosophila genomics
                        InterPro - A database of protein families, domains and functional sites
                        KEGG Genes - Molecular building blocks of life in the genomic space.
                        MARRVEL_MODEL - MARRVEL (model organism gene)
                        Linkouts
                        BioGRID - A database of protein and genetic interactions.
                        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                        DroID - A comprehensive database of gene and protein interactions.
                        DRSC - Results frm RNAi screens
                        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                        Flygut - An atlas of the Drosophila adult midgut
                        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                        MIST (genetic) - An integrated Molecular Interaction Database
                        MIST (protein-protein) - An integrated Molecular Interaction Database
                        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                        References (90)