FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\UbqnUAS.cGa
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General Information
Symbol
Dmel\UbqnUAS.cGa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Ganguly
FlyBase ID
FBal0217494
Feature type
allele
Associated gene
Dmel\Ubqn
Associated Insertion(s)
Carried in Construct
P{UAS-Ubqn.G}
Key Links
Transgenic product class
cDNA
(Ganguly et al., 2008)
wild_type
(Ganguly et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Ganguly et al., 2008)
wild_type
(Ganguly et al., 2008)
Mutagen
in vitro construct
(Ganguly et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-Ubqn.G}
Cytology
Description

UASt regulatory sequences drive expression of an EcoRI-XhoI fragment of the Ubqn LD38919 cDNA.

(Ganguly et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Ubqn
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  neurodegenerative disease
      CEA
      (Ganguly et al., 2008)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  neurodegenerative disease
      is ameliorated by PsnGMR.PG
      (Ganguly et al., 2008)
      is exacerbated by PsnD257A.GMR
      (Ganguly et al., 2008)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      3 day old adults expressing UbqnScer\UAS.cGa under the control of Scer\GAL4GMR.PF have normal eye morphology, with organised arrays of photoreceptors and non-neuronal pigment cells. However, by day 18, neurodegeneration is readily visible in the photoreceptors, with vacuoles and some cell loss, as well as degeneration in the pigment cells. Eye degeneration in these flies worsens progressively with age.

      (Ganguly et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Scer\GAL4GMR.PF, UbqnUAS.cGa has abnormal neuroanatomy phenotype, enhanceable by PsnD257A.GMR

      (Ganguly et al., 2008)
      Suppressed by
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Scer\GAL4GMR.PF, UbqnUAS.cGa has eye phenotype, enhanceable by PsnD257A.GMR

      (Ganguly et al., 2008)
      Suppressed by
      Statement
      Reference

      Scer\GAL4GMR.PF, UbqnUAS.cGa has eye phenotype, suppressible | partially by Diap1UAS.cHa, Scer\GAL4GMR.PF

      (Ganguly et al., 2008)

      Scer\GAL4GMR.PF, UbqnUAS.cGa has eye phenotype, suppressible | partially by PsnGMR.PG

      (Ganguly et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of thScer\UAS.cHa results in a marked rescue of the degeneration phenotype seen in the eyes of flies expressing UbqnScer\UAS.cGa under the control of Scer\GAL4GMR.PF.

      Co-expression of PsnGMR.PG strongly suppresses the degeneration phenotype seen in the eyes of 18 day old flies expressing UbqnScer\UAS.cGa under the control of Scer\GAL4GMR.PF.

      Co-expression of PsnD257A.GMR strongly enhances the degeneration phenotype seen in the eyes of 18 day old flies expressing UbqnScer\UAS.cGa under the control of Scer\GAL4GMR.PF.

      (Ganguly et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      UbqnScer\UAS.cGa
      UbqnUAS.cGa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Ganguly
      Secondary FlyBase IDs
        References (1)