FB2026_02 , released June 18, 2026
Allele: Dmel\PsnD257A.GMR
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General Information
Symbol
Dmel\PsnD257A.GMR
Species
D. melanogaster
Name
FlyBase ID
FBal0217497
Feature type
allele
Associated gene
Dmel\Psn
Associated Insertion(s)
Carried in Construct
P{GMR-Psn.D257A}
Key Links
Transgenic product class
dominant_negative_variant
(Ganguly et al., 2008)
missense_variant
(Ganguly et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Ganguly et al., 2008)
missense_variant
(Ganguly et al., 2008)
Mutagen
in vitro construct
(Ganguly et al., 2008)
Progenitor genotype
Carried in construct
P{GMR-Psn.D257A}
Cytology
Description

GMR regulatory sequences drive expression of a dominant negative version of Psn.

(Ganguly et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
GMR
Encoded product / tool
Psn
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  neurodegenerative disease
      modeled by UbqnUAS.cGa
      (Ganguly et al., 2008)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies carrying PsnD257A.GMR show only minimal neurodegeneration in the eye 18 days after eclosion.

      (Ganguly et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      PsnD257A.GMR is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4GMR.PF, UbqnUAS.cGa

      (Ganguly et al., 2008)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      PsnD257A.GMR is an enhancer of eye phenotype of Scer\GAL4GMR.PF, UbqnUAS.cGa

      (Ganguly et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of PsnD257A.GMR strongly enhances the degeneration phenotype seen in the eyes of 18 day old flies expressing UbqnScer\UAS.cGa under the control of Scer\GAL4GMR.PF.

      (Ganguly et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      PsnD257A.GMR
      PsnD257A
      (Ganguly et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)