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General Information
Symbol
Scer\GAL4Ilp3.PB
Species
S. cerevisiae
Name
Insulin-like peptide 3 promoter construct of Buch
FlyBase ID
FBal0241232
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Dilp3-GAL4, InsP3-Gal4
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

An 860bp Ilp3 promoter fragment regulates expression of a GAL4 driver.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Expression Data
Reporter Expression
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Information
Statement
Reference

Scer\GAL4Ilp3.PB drives expression in dorsomedial neurosecretory cells (mNSCs).

 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Ablation of Scer\GAL4Ilp3.PB-expressing median neurosecretory cells (mNSCs) extends lifespan of mated female flies compared to controls when flies are fed either 1x or 8x the optimal amount of sucrose. Ablated flies climb better than wild type flies with age, and this increase is unaffected by excess sugar intake. The increase in storage triacylglycerol (TAG) levels seen in wild type flies fed 8x the optimal amount of sugar is not observed in ablated flies: TAG levels are similar when flies are fed either 1x and 8x sugar.

A foxoΔ94 mutant background is unable to restore the normal sugar-induced increase in triacylglycerol levels that is seen upon ablation of the Scer\GAL4Ilp3.PB-expressing median neurosecretory cells (mNSCs).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

Scer\GAL4Ilp3.PB, rprUAS.C has long lived | drug conditional phenotype, suppressible | partially by foxoΔ94

NOT suppressed by
Statement
Reference
Suppressor of
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Scer\GAL4Ilp3.PB
Name Synonyms
Insulin-like peptide 3 promoter construct of Buch
Secondary FlyBase IDs
    References (10)