FlyBase Allele Report: Dmel\GABA-B-R2[KK100020]

General Information

Symbol

Dmel\GABA-B-R2^KK100020

Species

D. melanogaster

Name

FlyBase ID

FBal0258721

Feature type

allele

Associated gene

Dmel\GABA-B-R2

Associated Insertion(s)

Carried in Construct

P{KK100020}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK100020}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK100020

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates amyotrophic lateral sclerosis type 10

modeled by TBPH^Δ23, TBPH^GD6943

(Romano et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

short lived | nutrition conditional, with Scer\GAL4^Ilp2.PW

(Enell et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Male flies expressing GABA-B-R2^KK100020 under the control of Scer\GAL4^Ilp2.PW show significantly reduced survival in response to starvation compared to controls.

(Enell et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

GABA-B-R2^KK100020, Scer\GAL4^repo is a non-enhancer of abnormal wound healing | larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Li et al., 2020)

Suppressor of

Statement

Reference

Scer\GAL4^ppk.PU/GABA-B-R2^KK100020 is a suppressor | partially of abnormal wound healing | larval stage phenotype of Myc^QUAS.cPa, Ncra\QF^repo

(Li et al., 2020)

NOT Suppressor of

Statement

Reference

GABA-B-R2^KK100020, Scer\GAL4^repo is a non-suppressor of abnormal wound healing | larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Li et al., 2020)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

GABA-B-R2^KK100020, Scer\GAL4^repo is a non-enhancer of larval multidendritic class IV neuron phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Li et al., 2020)

Suppressor of

Statement

Reference

Scer\GAL4^ppk.PU/GABA-B-R2^KK100020 is a suppressor | partially of larval multidendritic class IV neuron phenotype of Myc^QUAS.cPa, Ncra\QF^repo

(Li et al., 2020)

NOT Suppressor of

Statement

Reference

GABA-B-R2^KK100020, Scer\GAL4^repo is a non-suppressor of larval multidendritic class IV neuron phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Li et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v110268

P{KK100020}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

GABA-B-R2^KK100020

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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