FlyBase Gene Report: Dmel\Ca-α1T

General Information

Symbol

Dmel\Ca-α1T

Species

D. melanogaster

Name

Ca²⁺-channel protein α₁ subunit T

Annotation Symbol

CG15899

Feature Type

protein_coding_gene

FlyBase ID

FBgn0264386

Gene Model Status

Current

Stock Availability

15 publicly available

Gene Summary

Ca[2+]-channel protein α[[1]] subunit T (Ca-α1T) encodes an α 1 subunit of a T-type like voltage gated calcium channel. It mediates a low voltage activated transient calcium current in antennal lobe projection neurons and wing motoneurons that is sensitive to amiloride. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

α1T, Ca1G

Key Links

Genomic Location

Cytogenetic map

5D5-5D7

Sequence location

X:6,104,085..6,192,483 [-]

Recombination map

1-15

RefSeq locus

NC_004354 REGION:6104085..6192483

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables low voltage-gated calcium channel activity

inferred from mutant phenotype

(Ryglewski et al., 2012)

inferred from direct assay

(Jeong et al., 2015)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables low voltage-gated calcium channel activity

inferred from biological aspect of ancestor with PANTHER:PTN000799039

(GO Reference Genome Project, 2011-)

enables monoatomic cation channel activity

inferred from electronic annotation with InterPro:IPR043203

(InterPro Project Members, 2004-)

enables monoatomic ion channel activity

inferred from electronic annotation with InterPro:IPR005821

(InterPro Project Members, 2004-)

enables voltage-gated calcium channel activity

inferred from electronic annotation with InterPro:IPR005445

(InterPro Project Members, 2004-)

enables voltage-gated sodium channel activity

inferred from biological aspect of ancestor with PANTHER:PTN000004137

(GO Reference Genome Project, 2011-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in calcium ion transmembrane transport via low voltage-gated calcium channel

inferred from direct assay

(Jeong et al., 2015)

involved_in calcium ion transmembrane transport

inferred from mutant phenotype

(Ryglewski et al., 2012)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in calcium ion import

inferred from biological aspect of ancestor with PANTHER:PTN000799039

(GO Reference Genome Project, 2011-)

involved_in calcium ion transmembrane transport

inferred from electronic annotation with InterPro:IPR005445

(InterPro Project Members, 2004-)

involved_in membrane depolarization during action potential

inferred from biological aspect of ancestor with PANTHER:PTN000004140

(GO Reference Genome Project, 2011-)

involved_in monoatomic ion transport

inferred from electronic annotation with InterPro:IPR005821

(InterPro Project Members, 2004-)

involved_in transmembrane transport

inferred from electronic annotation with InterPro:IPR005821

(InterPro Project Members, 2004-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR005821

(InterPro Project Members, 2004-)

is_active_in neuron projection

inferred from biological aspect of ancestor with PANTHER:PTN000799039

(GO Reference Genome Project, 2011-)

located_in plasma membrane

inferred from electronic annotation with InterPro:IPR043203

(InterPro Project Members, 2004-)

inferred by curator from GO:0008332

(Jeong et al., 2015)

part_of voltage-gated calcium channel complex

inferred from electronic annotation with InterPro:IPR005445

(InterPro Project Members, 2004-)

part_of voltage-gated sodium channel complex

inferred from biological aspect of ancestor with PANTHER:PTN000004137

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

VOLTAGE-GATED CALCIUM CHANNEL PORE SUBUNITS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

VOLTAGE-GATED CALCIUM CHANNEL PORE SUBUNITS -: Voltage-gated Ca[2+] channels (CACN) allow the influx of extracellular Ca[2+] in response to plasma membrane depolarization. The α1 subunits are pore-forming proteins that encompass the voltage sensor and gating mechanism. (Adapted from FBrf0218524 and PMID:21746798).

Summary (Interactive Fly)

voltage-gated calcium channel underlying the amiloride-sensitive transient current, projection neurons located in the antennal lobe, negative modulation of sleep, voltage-activated calcium currents in Drosophila motoneurons

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ca-α1T for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry M9PGH9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ca-α1T-RB

FBtr0089393

NM_132068

10842

3188

Ca-α1T-RC

FBtr0112953

NM_001103419

10893

3205

Ca-α1T-RD

FBtr0304609

NM_001258615

10818

3180

Ca-α1T-RE

FBtr0304610

NM_001258616

10878

3200

Ca-α1T-RF

FBtr0334984

NM_001272338

13025

3218

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Ca-α1T-PB

FBpp0088415

352.2

3188

9.02

FBpp0111866

354.2

3205

8.96

FBpp0293151

351.3

3180

9.00

FBpp0293152

353.5

3200

8.91

FBpp0306997

355.8

3218

9.00

M9PGH9

NP_001259267

AGB95113

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ca-α1T using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ca-alpha1T_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.73

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: TI{GT-GAL4}Ca-α1T^Gal4

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain

(Jeong et al., 2015)

adult antennal lobe

(Jeong et al., 2015)

adult mushroom body | restricted

(Jeong et al., 2015)

adult central complex

(Jeong et al., 2015)

adult optic lobe

(Jeong et al., 2015)

calyx of adult mushroom body

(Jeong et al., 2015)

pedunculus neck of adult mushroom body

(Jeong et al., 2015)

Reporter: TI{TI}Ca-α1T^GFP

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain

(Jeong et al., 2015)

adult antennal lobe

(Jeong et al., 2015)

adult mushroom body | restricted

(Jeong et al., 2015)

adult central complex | intense

(Jeong et al., 2015)

adult optic lobe

(Jeong et al., 2015)

calyx of adult mushroom body | intense

(Jeong et al., 2015)

pedunculus neck of adult mushroom body

(Jeong et al., 2015)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ca-α1T in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ca-α1T

View exonic expression by tissue for Dmel\Ca-α1T

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31550/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264386

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0029846

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264386

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 19 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ca-α1T

Transgenic constructs containing regulatory region of Ca-α1T

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(1)Exel6238

(Ryder, 2004.4.26)

Inferred from location ( 17 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

Ca-α1T^GD3252

viable

Ca-α1T^d02621

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

Ca-α1T^GD7754

viable, with Scer\GAL4^pnr-MD237

Ca-α1T^GD7754

viable, with Scer\GAL4^tin.CΔ4

Sterility

Allele

fertile

Ca-α1T^d02621

Other Phenotypes

Allele

abnormal behavior | adult stage

Ca-α1T^Gal4

abnormal circadian rhythm | adult stage

Ca-α1T^Gal4

abnormal locomotor behavior | adult stage | male limited | progressive

Ca-α1T^del

abnormal neurophysiology | adult stage

Ca-α1T^del

abnormal sleep | adult stage

abnormal sleep | adult stage, with Ca-α1T^Gal4, Scer\GAL4^Ca-α1T

Ca-α1T^GD3252

abnormal sleep | adult stage, with Ca-α1T^GD3252, Scer\GAL4^Ca-α1T

Ca-α1T^Gal4

abnormal sleep | adult stage, with Scer\GAL4^104y

Ca-α1T^GD3252

abnormal sleep | adult stage, with Scer\GAL4^elav-C155

Ca-α1T^GD3252

abnormal sleep | adult stage (with Ca-α1T^Δ3)

abnormal sleep | adult stage (with Ca-α1T^Δ115)

abnormal sleep | adult stage (with Ca-α1T^Δ135)

abnormal sleep | adult stage | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

Ca-α1T^GD3252

short lived

Ca-α1T^del

Phenotype manifest in

Allele

adult heart

Ca-α1T^del

indirect flight muscle motor neuron DLMN5

Ca-α1T^del

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (27)

Hsap\CACNA1G

12 of 14

Yes

Hsap\CACNA1H

12 of 14

Yes

Hsap\CACNA1I

12 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

Yes

Hsap\CATSPER3

2 of 14

Yes

Hsap\CATSPER4

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\TPCN2

2 of 14

Yes

Hsap\CATSPER2

1 of 14

Hsap\SCN1A

1 of 14

Hsap\SCN7A

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (27)

Rnor\Cacna1h

12 of 14

Yes

Rnor\Cacna1g

11 of 14

Yes

Rnor\Cacna1i

11 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Rnor\Catsper4

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (27)

Mmus\Cacna1g

12 of 14

Yes

Mmus\Cacna1i

12 of 14

Yes

Mmus\Cacna1h

11 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

Yes

Mmus\Catsper3

2 of 14

Yes

Mmus\Catsper4

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Mmus\Tpcn2

2 of 14

Yes

Mmus\Catsper2

1 of 14

Mmus\Scn2a

1 of 14

Xenopus tropicalis (Western clawed frog) (25)

Xtro\cacna1h

10 of 13

Yes

Xtro\cacna1g

7 of 13

Yes

Xtro\cacna1i

6 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (29)

Drer\cacna1g

12 of 14

Yes

Drer\cacna1ha

12 of 14

Yes

Drer\cacna1hb

11 of 14

Yes

Drer\cacna1ia

11 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\tpcn3

2 of 14

Yes

Drer\cacna1db

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\cca-1

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Anopheles gambiae (African malaria mosquito) (10)

Agam\AgaP_AGAP002505

12 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Yes

Arabidopsis thaliana (thale-cress) (1)

Atha\TPC1

3 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\CCH1

5 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\cch1

4 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Ca-α1T. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (6)

cac

6 of 13

NaCP60E

6 of 13

para

6 of 13

Ca-α1D

5 of 13

4 of 13

Shab

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CACNA1G; calcium voltage-gated channel subunit alpha1 G

model of cerebellar ataxia type 42

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CACNA1G; calcium voltage-gated channel subunit alpha1 G

12 of 14

604065

cerebellar ataxia type 42

CACNA1H; calcium voltage-gated channel subunit alpha1 H

12 of 14

607904

CACNA1I; calcium voltage-gated channel subunit alpha1 I

12 of 14

608230

NEURODEVELOPMENTAL DISORDER WITH SPEECH IMPAIRMENT AND WITH OR WITHOUT SEIZURES; NEDSIS

CACNA1A; calcium voltage-gated channel subunit alpha1 A

3 of 14

CALCIUM CHANNEL, VOLTAGE-DEPENDENT, P/Q TYPE, ALPHA-1A SUBUNIT; CACNA1A

CACNA1B; calcium voltage-gated channel subunit alpha1 B

3 of 14

601012

NEURODEVELOPMENTAL DISORDER WITH SEIZURES AND NONEPILEPTIC HYPERKINETIC MOVEMENTS; NEDNEH

CACNA1C; calcium voltage-gated channel subunit alpha1 C

3 of 14

114205

CACNA1D; calcium voltage-gated channel subunit alpha1 D

3 of 14

114206

CACNA1E; calcium voltage-gated channel subunit alpha1 E

3 of 14

601013

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 69; DEE69

developmental and epileptic encephalopathy 69

CACNA1F; calcium voltage-gated channel subunit alpha1 F

3 of 14

300110

CACNA1S; calcium voltage-gated channel subunit alpha1 S

3 of 14

114208

NALCN; sodium leak channel, non-selective

3 of 14

611549

congenital limbs-face contractures-hypotonia-developmental delay syndrome

SCN5A; sodium voltage-gated channel alpha subunit 5

3 of 14

SODIUM VOLTAGE-GATED CHANNEL, ALPHA SUBUNIT 5; SCN5A

SCN8A; sodium voltage-gated channel alpha subunit 8

3 of 14

600702

SCN10A; sodium voltage-gated channel alpha subunit 10

3 of 14

604427

EPISODIC PAIN SYNDROME, FAMILIAL, 2; FEPS2

familial episodic pain syndrome 2

SCN11A; sodium voltage-gated channel alpha subunit 11

3 of 14

604385

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0264386

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-15

Cytogenetic map

5D5-5D7

Sequence location

X:6,104,085..6,192,483 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

5D5-5D7

Limits computationally determined from genome sequence between P{EP}EP1457^EP1457&P{EP}CG5928^EP1083 and P{EP}EP1311&P{EP}EP1384;

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-15

(FlyBase, 2016)

1-15.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (15)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

68200

w¹¹¹⁸ Ca-α1T^Δ135

68202

w¹¹¹⁸ TI{TI}Ca-α1T^GFP

19179

w¹¹¹⁸ P{XP}Ca-α1T^d02621

51994

w¹¹¹⁸ PBac{WHr}Ca-α1T^del

26251

y¹ v¹; P{TRiP.JF02150}attP2

68201

w¹¹¹⁸ TI{GT-GAL4}Ca-α1T^Gal4

39029

y¹ v¹; P{TRiP.HMS01948}attP40

44990

y¹ w^* Mi{MIC}Ca-α1T^MI08565

51222

y¹ w^* Mi{MIC}Ca-α1T^MI08189

VDRC

v108827

P{KK100082}VIE-260B

v31961

w¹¹¹⁸; P{GD7754}v31961

v48008

w¹¹¹⁸; P{GD3252}v48008

More stocks available...

Genomic Clones (45)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (9)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0264386

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Jeong et al., 2015)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: Ca-α1T Ca1G

(Ryglewski et al., 2012)

Additional comments

Annotations CG15899, CG4222 and CG12544 merged as CG15899 (which corresponds to Ca-α1T) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: Ca-α1T CG4222 CG15899

(Mittman, 2001.4.17)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

CG12544

(Tsubouchi et al., 2012, Luschnig, 2003.12.17)

CG15899

(Metwally et al., 2019, Lin et al., 2018, Hosono et al., 2015, Kanamori et al., 2013, Ryglewski et al., 2012, Ni et al., 2010.12.1, Pessa et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31, Alekseyenko et al., 2006, Agrawal and Stormo, 2005, Hall and Xu, 2005, Schneider et al., 2004, Mittman, 2001.4.17)

CG4222

(Mittman, 2001.4.17)

Ca-a1T

(Hertzler et al., 2024)

Ca-alpha1T

(Corthals et al., 2023, Huang et al., 2022, McLaughlin et al., 2021, Pang et al., 2021, Meltzer et al., 2019, Croset et al., 2018, Zajitschek et al., 2017, Gene Disruption Project members, 2016-, Gene Disruption Project members, 2015-, Ashwal-Fluss et al., 2014, Vernes, 2014, Wolfram et al., 2014, Sen et al., 2013, Rodriguez et al., 2012, Pessa et al., 2010, Wasbrough et al., 2010, Alekseyenko et al., 2006, Giot et al., 2003)

Ca-alphaT-RC

(Lin et al., 2010)

Ca-α1T

(Bischoff et al., 2025, Qiao et al., 2022, Scaplen and Petruccelli, 2021, Xie et al., 2021, Li et al., 2020, Perry et al., 2020, Vajente et al., 2020, Ly et al., 2018, Tomita et al., 2017, Terada et al., 2016, Tong et al., 2016, Hu et al., 2015, Jeong et al., 2015, Tsubouchi et al., 2012, Kuromi et al., 2010)

Ca1G

Caalpha1T

(Mittman, 2001.4.11)

Dmca1G

(Molitor et al., 2000)

DmαG

(Ryglewski et al., 2012)

T-type Ca²⁺

(Lam et al., 2018)

ca-α1T

(Kanamori et al., 2013)

cat

(Savva et al., 2012)

α1T

(Liang et al., 2022, Iniguez et al., 2013)

αIT

(Metwally et al., 2019)

Name Synonyms

Ca-α1T

Ca1G

Ca2+-channel protein α1 subunit T

(Shafer, 2025)

Secondary FlyBase IDs

FBgn0029846
FBgn0029844
FBgn0029845
FBgn0041343

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 54 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31550

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

M9PGH9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

M9PGH9

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31550/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264386

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264386

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG15899

MARRVEL_MODEL - MARRVEL (model organism gene)

31550

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0264386

DroID - A comprehensive database of gene and protein interactions.

FBgn0264386

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ca-alpha1T_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0029846

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0264386

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034186

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

References (102)

The following external sites may use different assemblies or annotations than FlyBase.

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