FlyBase Gene Report: Dmel\na

General Information

Symbol

Dmel\na

Species

D. melanogaster

Name

narrow abdomen

Annotation Symbol

CG1517

Feature Type

protein_coding_gene

FlyBase ID

FBgn0002917

Gene Model Status

Current

Stock Availability

12 publicly available

Gene Summary

narrow abdomen (na) encodes an ion channel involved in circadian locomotor rhythms and touch perception. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

har38, har, NALCN, har85

Key Links

Genomic Location

Cytogenetic map

12E6-12E7

Sequence location

X:14,266,367..14,277,416 [+]

Recombination map

1-48

RefSeq locus

NC_004354 REGION:14266367..14277416

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (19 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables monoatomic ion channel activity

inferred from mutant phenotype

(Lear et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables monoatomic cation channel activity

inferred from biological aspect of ancestor with PANTHER:PTN000799098

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR028823

(InterPro Project Members, 2004-)

enables monoatomic ion channel activity

inferred from electronic annotation with InterPro:IPR005821

(InterPro Project Members, 2004-)

Biological Process (12 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

involved_in adult locomotory behavior

inferred from mutant phenotype

(Nash et al., 2002)

involved_in circadian behavior

inferred from direct assay

(Zhang et al., 2010)

involved_in locomotor rhythm

inferred from mutant phenotype

(Ghezzi et al., 2014, Lear et al., 2013)

involved_in regulation of circadian rhythm

inferred from mutant phenotype

(Lear et al., 2005)

involved_in response to anesthetic

inferred from mutant phenotype

(Humphrey et al., 2007)

involved_in rhythmic behavior

inferred from mutant phenotype

(Moose et al., 2017)

involved_in sensory perception of touch

inferred from mutant phenotype

(Tsubouchi et al., 2012)

involved_in social behavior

inferred from mutant phenotype

(Ghezzi et al., 2014)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in monoatomic ion transport

inferred from electronic annotation with InterPro:IPR005821

(InterPro Project Members, 2004-)

involved_in positive regulation of synaptic transmission, cholinergic

inferred from biological aspect of ancestor with PANTHER:PTN000799098

(GO Reference Genome Project, 2011-)

involved_in positive regulation of synaptic transmission, GABAergic

inferred from biological aspect of ancestor with PANTHER:PTN000799098

(GO Reference Genome Project, 2011-)

involved_in transmembrane transport

inferred from electronic annotation with InterPro:IPR005821

(InterPro Project Members, 2004-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in axon terminus

inferred from direct assay

(Lear et al., 2005)

part_of cation channel complex

inferred from physical interaction with FLYBASE:unc79; FB:FBgn0038693,FLYBASE:unc80; FB:FBgn0039536

(Lear et al., 2013)

located_in neuronal cell body

inferred from direct assay

(Lear et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR005821

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000799098

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

SODIUM LEAK CHANNEL COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

narrow abdomen (na) encodes an ion channel involved in circadian locomotor rhythms and touch perception. [Date last reviewed: 2019-09-26]

Gene Group (FlyBase)

SODIUM LEAK CHANNEL COMPLEX -: The sodium leak channel is a non-selective, constitutively active monovalent cation channel complex that conducts depolarizing sodium ion leak currents in electrically excitable cells to regulate resting membrane potential. The complex consists of the channel-forming na and accessory subunits, which are required for reconstituting a functional channel. (Adapted from PMID:37615954.)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

na: narrow abdomen

Abdomen long and cylindrical in both sexes. Viability low; female fertility low. Ovaries in juvenile condition (Brehme). RK2.

*na2

Like na. RK2.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\na for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A8JUW5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.49

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

na-RF

FBtr0344822

NM_001103511

7875

2233

na-RG

FBtr0344823

NM_167401

7606

2224

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

na-PF

FBpp0311138

247.1

2233

9.51

FBpp0311139

246.1

2224

9.41

R9PY25

NP_727772

AAF48365

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\na using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

na_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.77

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

ellipsoid body | subset

(Nash et al., 2002)

adult optic lobe | subset

(Nash et al., 2002)

supraesophageal ganglion | subset

(Nash et al., 2002)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Dorus et al., 2006)

Additional Descriptive Data

Expression of protein is observed in synaptic regions (neuropil) of the adult brain. There is high staining detected in the lateral triangles of the ellipsoid body. Prominent staining is also observed in several distinct layers of the optic lobe including the medulla, lobula and a single row of cells in the distal lamina.

(Nash et al., 2002)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in axon terminus

inferred from direct assay

(Lear et al., 2005)

part_of cation channel complex

inferred from physical interaction with FLYBASE:unc79; FB:FBgn0038693,FLYBASE:unc80; FB:FBgn0039536

(Lear et al., 2013)

located_in neuronal cell body

inferred from direct assay

(Lear et al., 2005)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\na in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\na

View exonic expression by tissue for Dmel\na

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

45338/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0002917

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0002917

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0002917

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1517

Flygut - An atlas of the Drosophila adult midgut

FBgn0002917

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 14 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of na

Transgenic constructs containing regulatory region of na

Aberrations (Deficiencies and Duplications) ( 16 )

Inferred from experimentation ( 16 )

Gene duplicated in

Dp(1;3)DC282

(Popodi et al., 2010-, Venken et al., 2010)

Dp(1;f)LJ4

(Livingstone, 1985, Hardy et al., 1984)

Dp(1;f)LJ8

(Hardy et al., 1984)

Dp(1;f)LJ9

(Hardy et al., 1984)

Dp(1;Y)y⁺na⁺

Gene disrupted in

Df(1)BSC857

(Cook et al., 2009.11.25)

Df(1)CO-1

(Mir et al., 1997)

Df(1)CO-2

(Mir et al., 1997)

Df(1)KA9

(Krishnan and Nash, 1990, Hardy et al., 1984, Craymer and Roy, 1980)

Df(1)RK2

(Mir et al., 1997, Krishnan and Nash, 1990)

Gene not disrupted in

Df(1)AR2

(Muralidhar and Thomas, 1993)

Df(1)AR10

(Muralidhar and Thomas, 1993)

Df(1)HA92

(Krishnan and Nash, 1990, Craymer and Roy, 1980)

Df(1)RK5

(Krishnan and Nash, 1990)

Gene not duplicated in

Dp(1;3)v⁺74c

(Schalet, 1986)

Dp(1;4)r⁺l

(Schalet, 1986)

Inferred from location ( 17 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

na^GD1172

lethal, with Scer\GAL4^Act5C.PU

na^GD1172

lethal, with Scer\GAL4^GMR.PF, Scer\GAL4^ey.PH

na^GD1172

lethal, with Scer\GAL4^insc-Mz1407

na^GD1172

lethal, with Scer\GAL4^Mef2.PR

na^GD1172

partially lethal, with Scer\GAL4^tim.PE

na^E.UAS

partially lethal - majority die, with Scer\GAL4^pnr-MD237

na^GD1172

viable

na^e04385

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

na^KK102435

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

na^GD1172

viable, with Scer\GAL4^tin.CΔ4

na^GD1172

Sterility

Allele

fertile

na^e04385

Other Phenotypes

Allele

abnormal behavior

na^unspecified

abnormal circadian behavior

na^har

abnormal circadian behavior, with Scer\GAL4^Clk.1.5

na^UAS.cLa

abnormal circadian behavior, with Scer\GAL4^tim.PE

na^KK102435

abnormal flight, with Scer\GAL4^elav.PLu

na^GD1172

abnormal flight, with Scer\GAL4^Mef2.PR

na^GD1172

abnormal locomotor behavior

na^e04385

abnormal locomotor behavior, with Scer\GAL4^elav.PLu

na^GD1172

abnormal locomotor behavior, with Scer\GAL4^Mef2.PR

na^GD1172

abnormal locomotor behavior | adult stage

abnormal locomotor behavior | recessive

abnormal locomotor rhythm

abnormal locomotor rhythm, with Scer\GAL4^cry.PZ

na^UAS.cLa

abnormal locomotor rhythm, with Scer\GAL4^P2.4.Pdf

na^UAS.cLa

abnormal locomotor rhythm, with Scer\GAL4^tim.PE

na^UAS.cLa

abnormal locomotor rhythm | adult stage, with Scer\GAL4^elav-C155

na^JF01826

abnormal neuroanatomy | larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^1003.3

na^GD1172

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

na^GD1172

abnormal touch response, with Scer\GAL4^109(2)80

na^GD1172

abnormal touch response, with Scer\GAL4^1003.3

na^GD1172

abnormal touch response | larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^1003.3

na^GD1172

chemical resistant

na^har38

chemical resistant | recessive

chemical sensitive

chemical sensitive | recessive

some die during pupal stage, with Scer\GAL4^pnr-MD237

na^GD1172

visible, with Scer\GAL4^pnr-MD237

na^GD1172

visible | recessive

wild-type

Phenotype manifest in

Allele

adult abdomen

adult head

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

na^GD1172

larval dorsal multidendritic neuron ddaA | larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^1003.3

na^GD1172

mesonotum, with Scer\GAL4^pnr-MD237

na^GD1172

sensory dendrite | larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^1003.3

na^GD1172

thorax, with Scer\GAL4^pnr-MD237

na^GD1172

wing, with Scer\GAL4^Bx-MS1096

na^GD1172

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (21)

Hsap\NALCN

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (21)

Rnor\Nalcn

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (21)

Mmus\Nalcn

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (14)

Xtro\nalcn

8 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (25)

Drer\nalcn

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\nca-2

13 of 14

Yes

Cele\unc-77

12 of 14

Yes

Cele\F17C8.6

4 of 14

Yes

Cele\cca-1

2 of 14

Cele\egl-19

2 of 14

Cele\unc-2

2 of 14

Anopheles gambiae (African malaria mosquito) (9)

Agam\AgaP_AGAP003921

11 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\CCH1

5 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\cch1

7 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:na. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (5)

Ca-α1D

4 of 13

Ca-α1T

4 of 13

cac

4 of 13

NaCP60E

3 of 13

para

3 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

NALCN; sodium leak channel, non-selective

model of congenital limbs-face contractures-hypotonia-developmental delay syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

NALCN; sodium leak channel, non-selective

13 of 14

611549

congenital limbs-face contractures-hypotonia-developmental delay syndrome

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

na - unc79

anti bait coimmunoprecipitation, western blot

(Lear et al., 2013)

na - unc80

anti bait coimmunoprecipitation, western blot

(Lear et al., 2013)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

Dcr-2

(Dietzl et al., 2007)

enhanceable

(Campbell and Nash, 2001)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0002917

MIST (protein-protein) - An integrated Molecular Interaction Database

45338

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Stimuli-sensing channels

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-48

Cytogenetic map

12E6-12E7

Sequence location

X:14,266,367..14,277,416 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

12E6-12E7

Limits computationally determined from genome sequence between P{EP}l(1)G0007^EP764 and P{EP}EP1599

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

12E-12F

(determined by in situ hybridisation)

(Mir et al., 1997)

12E2-12E5

(Mir and Krishnan, 1995)

Experimentally Determined Recombination Data

Location

1-48

(FlyBase, 2016)

1-45.9

(Comeron et al., 2012)

1-46.9

(Hardy et al., 1984)

1-45.2

(Edmondson, 1952)

Left of (cM)

Adcy1

(Krishnan and Nash, 1990)

Right of (cM)

(Krishnan and Nash, 1990)

Notes

Stocks and Reagents

Stocks (12)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

26704

na^har38/FM6

18255

w¹¹¹⁸ PBac{RB}na^e04385

na¹/C(1)DX, y¹ f¹

25808

y¹ v¹; P{TRiP.JF01826}attP2

26702

y¹ w^a na^har85/FM7a

38061

y¹ w^* Mi{MIC}na^MI04852

Kyoto

107483

C(1;Y)1, y¹ g² na¹/FM3/Dp(1;f)LJ8, y⁺ g⁺ na⁺ Ste⁺

1517R-1

v103754

v3306

w¹¹¹⁸; P{GD1172}v3306

v342772

P{hsFLP}1, y1 w1118; P{HD_CFD01772}attP40/CyO-GFP

v342934

P{hsFLP}1, y1 w1118; P{HD_CFD02353}attP40/CyO-GFP

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (10)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0002917

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0002917

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Nash et al., 2002)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

na is an important modulator of neural function.

(Nash et al., 2002)

Shows genomic imprinting on Dp(1;f)LJ9.

(Lloyd et al., 1999)

Mosaic analysis suggests that the entire head is the focus for the anesthesia and behavioural phenotypes of na mutant alleles.

(Mir et al., 1997)

Mutations of na display variable resistance and sensitivity to volatile anaesthetics, this demonstrates that the potency of an anaesthetic is influenced by its chemical structure.

(Campbell and Nash, 1994)

"1-46.9" was stated as revision.

(Hardy et al., 1984)

The relationship between the determinant on the X chromosome involved in resistance to halothane anesthesia described in FBrf0038409 and na is unclear.

(Gamo et al., 1982)

Relationship to Other Genes

Source for database merge of

Source for merge of: na CG1517

(Nash, 2002.3.23)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: α1U CG1517 na

(Nash, 2002.3.23)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

CG1517

(Hosono et al., 2015, Tsubouchi et al., 2012, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15, Malko et al., 2006, Lear et al., 2003, Nash et al., 2002)

Dma1U

(Lear et al., 2003)

Dmα1U

(Nash et al., 2002)

(Moose et al., 2017, Flourakis et al., 2015, Lear et al., 2013)

NALCN

(Moose et al., 2017, Ghezzi et al., 2014)

(Li et al., 2024, Weber et al., 2009)

har

(Guan and Nash, 1997, Leibovitch et al., 1995)

har 38

(Nishikawa and Kidokoro, 1999)

har 85

(Nishikawa and Kidokoro, 1999)

har38

(Shaw and Franken, 2003, Campbell and Nash, 2001, Rajaram and Nash, 2001, Mir and Krishnan, 1995)

har85

(Mir and Krishnan, 1995)

harA

(Nash et al., 1997)

α1U

(Nash et al., 2002)

Name Synonyms

NARROW ABDOMEN

(Moose et al., 2017, Lear et al., 2013)

halothane-resistant

narrow abdomen

(Murakami et al., 2021, Flourakis et al., 2015, Pool et al., 2012, Tsubouchi et al., 2012, Zhang et al., 2010, Anaka et al., 2009, Humphrey et al., 2007, van Swinderen, 2006, Lear et al., 2005, Madhavan et al., 2000)

Secondary FlyBase IDs

FBgn0004144
FBgn0030560

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

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Title

External Crossreferences and Linkouts ( 37 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

45338

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A8JUW5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A8JUW5

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

45338/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0002917

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0002917

FlyMine - An integrated database for Drosophila genomics

FBgn0002917

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1517

MARRVEL_MODEL - MARRVEL (model organism gene)

45338

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0002917

DroID - A comprehensive database of gene and protein interactions.

FBgn0002917

DRSC - Results frm RNAi screens

FBgn0002917

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

na_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0002917

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0002917

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1517

Flygut - An atlas of the Drosophila adult midgut

FBgn0002917

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0002917

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC001338

MIST (protein-protein) - An integrated Molecular Interaction Database

45338

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Stimuli-sensing channels

References (115)

The following external sites may use different assemblies or annotations than FlyBase.

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