Mobilisation of an X-linked P{GawB} generates this line.
Scer\GAL41003.3 may also drive expression in abdominal dorsal multidendritic neurons ddaD and ddaE.
Scer\GAL41003.3 drives expression in the PNS neurons, including class I and class II dendritic arborizing neurons, external sensory organs and the vch1 and vch2 chordotonal organs. Labelling is also seen in the lateral ventral nerve cord and a few cells in the brain.
Inhibition (using Hsap\KCNJ2UAS.EGFP) of a subset of Scer\GAL41003.3 cells (inhibition restricted using Scer\GAL80tsh-GAL80) in larvae significantly reduces nociceptive movement responses following stimulation with a von Frey filament, compared to controls; there is also a significant reduction in the response to gentle touch, compared to controls.
Inhibition (using Ctet\tetXTNT-LC.UAS) of a subset of Scer\GAL41003.3 cells (activation restricted using Scer\GAL80tsh-GAL80) in larvae significantly reduces nociceptive movement responses following stimulation with a von Frey filament, but does not affect the latency of rolling in response to high temperature (local) stimulation, compared to controls.
Optogenetic activation (using Cnoc\ChR1::Csub\ChRCsChrimson.IVS.20xUAS.Venus with 625 nm (red) light) of a subset of Scer\GAL41003.3 cells (activation restricted using Scer\GAL80tsh-GAL80) in larvae results in contractions without rolling in the absence of pain stimuli, this is not seen in controls.
SmnUAS.Tag:FLAG/Scer\GAL41003.3 fails to rescue SmnX7