Larvae expressing Nmdar2GD3192 under the control of Scer\GAL41003.3 (in the presence of Dcr-2Scer\UAS.cDa to enhance RNAi) show a reduced response to gentle touch compared to controls. Class III ddaA neurons in these larvae show a significant decrease in the number of dendritic sensory filopodia compared to wild type. The average length of the filopodia is significantly decreased, while the total length of primary dendritic branches is not altered.
Adults expressing Nmdar2GD3192 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.
Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in viable flies or early pupal lethality.
Expression under the control of Scer\GAL4pnr-MD237 may result in lethality, depending on the insertion line used.