FlyBase Gene Report: Dmel\stj

General Information

Symbol

Dmel\stj

Species

D. melanogaster

Name

straightjacket

Annotation Symbol

CG12295

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261041

Gene Model Status

Stock Availability

15 publicly available

Gene Snapshot

straightjacket (stj) encodes a voltage-gated calcium channel subunit involved in neuromuscular junction development and autophagosome maturation. [Date last reviewed: 2019-09-12]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

α₂δ, α₂δ-3, dα₂δ-3

Key Links

Genomic Location

Cytogenetic map

Sequence location

2R:13,805,794..13,819,571 [+]

Recombination map

2-68

RefSeq locus

NT_033778 REGION:13805794..13819571

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables voltage-gated calcium channel activity

inferred from biological aspect of ancestor with PANTHER:PTN000018330

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with UniProtKB:Q8CFG5

(FlyBase Curators, 2008--)

Biological Process (8 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in autophagosome maturation

inferred from mutant phenotype

(Tian et al., 2015)

involved_in bulk synaptic vesicle endocytosis

inferred from direct assay

(Kuromi et al., 2010)

involved_in detection of temperature stimulus involved in sensory perception of pain

inferred from mutant phenotype

(Neely et al., 2010)

involved_in negative regulation of synaptic growth at neuromuscular junction

inferred from mutant phenotype

(Dickman et al., 2008)

involved_in neuromuscular junction development

inferred from direct assay

(Kurshan et al., 2009)

involved_in neuromuscular synaptic transmission

inferred from mutant phenotype

(Heinrich and Ryglewski, 2020, Dickman et al., 2008)

involved_in positive regulation of voltage-gated calcium channel activity

inferred from mutant phenotype

(Heinrich and Ryglewski, 2020)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in calcium ion transport

inferred from sequence or structural similarity with UniProtKB:Q8CFG5

(FlyBase Curators, 2008--)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in presynaptic active zone

inferred from direct assay

(Kuromi et al., 2010)

located_in synapse

inferred from direct assay

(Ly et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of voltage-gated calcium channel complex

inferred from biological aspect of ancestor with PANTHER:PTN000018330

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

VOLTAGE-GATED CALCIUM CHANNEL SUBUNITS

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

VOLTAGE-GATED CALCIUM CHANNEL SUBUNITS -: Voltage-gated Ca²⁺ channels (CACN) allow the influx of extracellular Ca²⁺ in response to plasma membrane depolarization. CACNs are hetero-oligomeric assemblies of a pore-forming α₁ subunit plus other structural and accessory subunits. (Adapted from FBrf0218524 and PMID:21746798).

Gene Model and Products

Number of Transcripts

3

Number of Unique Polypeptides

3

Please see the JBrowse view of Dmel\stj for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0087631

6057

1218

FBtr0304694

5825

1271

FBtr0304695

4866

1237

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0086757

140.0

1218

6.63

FBpp0293237

145.8

1271

6.67

FBpp0293238

142.3

1237

6.47

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\stj using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

stj_1
stj_2

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16 -- 17

ventral nerve cord

(Ly et al., 2008)

embryonic/larval central nervous system

(Ly et al., 2008)

embryonic/larval brain

(Ly et al., 2008)

embryonic stage 11 -- 15

presumptive embryonic/larval central nervous system

(Ly et al., 2008)

Additional Descriptive Data

stj is expressed in the embryonic nervous system starting in stage 11 and is highly enriched in the brain and ventral nerve cord in later embryos.

(Ly et al., 2008)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in presynaptic active zone

inferred from direct assay

(Kuromi et al., 2010)

located_in synapse

inferred from direct assay

(Ly et al., 2008)

Expression Deduced from Reporters

Reporter: P{GawB}stj^NP1574

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval brain

(Ly et al., 2008)

ventral nerve cord | restricted

Comment: in subset of motor neurons and interneurons

(Ly et al., 2008)

larval central brain

(Olson et al., 2019)

embryonic/larval wrapping glial cell of the eye disc

(Olson et al., 2019)

(Ly et al., 2008)

adult ventral nervous system | restricted

(Ly et al., 2008)

adult optic lobe

(Ly et al., 2008)

embryonic/larval salivary gland

(Ly et al., 2008)

photoreceptor cell

Comment: in axons and terminals

(Ly et al., 2008)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\stj in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\stj

View exonic expression by tissue for Dmel\stj

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261041

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0261041

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12295

Flygut - An atlas of the Drosophila adult midgut

FBgn0261041

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 20 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of stj

Transgenic constructs containing regulatory region of stj

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation

Gene disrupted in

(Dickman et al., 2008, Ly et al., 2008, Spradling et al., 1999, BDGP Project Members, 1994-1999)

(Dickman et al., 2008, Ly et al., 2008, Ryder, 2004.4.26)

Gene not disrupted in

(BDGP Project Members, 1994-1999)

(BDGP Project Members, 1994-1999)

Inferred from location

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Df(2R)CX1)

lethal (with Df(2R)Exel7128)

stj^{MI00783-TG4.0}

lethal (with stj^DD106)

lethal (with stj^DD131)

lethal (with stj^DD173)

lethal (with stj^DD174)

lethal (with stj^DD196)

lethal (with stj^k10814)

lethal | recessive

lethal - all die before end of pupal stage (with Df(2R)Exel7128)

lethal - all die before end of pupal stage (with stj¹)

lethal - all die before end of pupal stage (with stj²)

lethal - all die before end of pupal stage (with stj³)

lethal - all die during embryonic stage

lethal - all die during embryonic stage (with Df(2R)CX1)

stj^DD131

lethal - all die during embryonic stage (with Df(2R)Exel7128)

lethal - all die during embryonic stage | recessive

stj^DD131

partially lethal - majority die (with Df(2R)CX1)

stj^k10814

partially lethal - majority die (with Df(2R)Exel7128)

stj^k10814

partially lethal - majority die | recessive

stj^k10814

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

stj^JF01825

viable, with Scer\GAL4^Mef2.PR

stj^GD1985

viable, with Scer\GAL4^pnr-MD237

stj^GD1985

Other Phenotypes

Allele

abnormal heat stress response | adult stage

stj²

abnormal heat stress response | adult stage, with Scer\GAL4^ppk.PG

abnormal heat stress response | third instar larval stage, with Scer\GAL4^ppk.PG

abnormal locomotor behavior | adult stage (with Df(2R)CX1)

stj^k10814

abnormal locomotor behavior | adult stage (with Df(2R)Exel7128)

stj^k10814

abnormal locomotor behavior | adult stage | recessive

stj^k10814

abnormal neuroanatomy | embryonic stage

abnormal neuroanatomy | embryonic stage (with Df(2R)Exel7128)

abnormal neurophysiology

stj^c01305

abnormal neurophysiology | embryonic stage

abnormal neurophysiology | embryonic stage (with Df(2R)Exel7128)

abnormal neurophysiology | recessive | third instar larval stage

stj^k10814

abnormal neurophysiology | somatic clone

abnormal neurophysiology | third instar larval stage (with Df(2R)CX1)

stj^k10814

abnormal neurophysiology | third instar larval stage (with Df(2R)Exel7128)

abnormal neurophysiology | third instar larval stage (with stj¹)

abnormal neurophysiology | third instar larval stage (with stj²)

stj¹

abnormal neurophysiology | third instar larval stage (with stj³)

stj¹

abnormal pain response | adult stage, with Scer\GAL4^elav.PLu

abnormal pain response | larval stage

stj²

abnormal pain response | larval stage, with Scer\GAL4^elav.PLu

stj^JF01825

abnormal pain response | larval stage (with Df(2R)Exel7128)

stj²

flightless (with Df(2R)CX1)

stj^k10814

flightless (with Df(2R)Exel7128)

stj^k10814

flightless | recessive

stj^k10814

some die during embryonic stage

some die during embryonic stage (with Df(2R)CX1)

stj^DD131

some die during embryonic stage (with Df(2R)Exel7128)

some die during embryonic stage | recessive

stj^DD131

some die during pupal stage (with Df(2R)Exel7128)

some die during pupal stage (with stj¹)

some die during pupal stage (with stj²)

some die during pupal stage (with stj³)

some die during third instar larval stage (with Df(2R)CX1)

stj^k10814

some die during third instar larval stage (with Df(2R)Exel7128)

stj^k10814

some die during third instar larval stage | recessive

stj^k10814

uncoordinated | adult stage (with Df(2R)Exel7128)

Phenotype manifest in

Allele

autophagosome | somatic clone | increased number

stj¹

bouton (with Df(2R)Exel7128)

bouton & larval neuromuscular junction | supernumerary (with stj^DD106)

stj^k10814

bouton & larval neuromuscular junction | supernumerary (with stj^k10814)

stj^DD106

embryonic/larval neuromuscular junction

stj^DD106

embryonic/larval neuromuscular junction (with Df(2R)Exel7128)

embryonic/larval neuromuscular junction (with stj¹)

embryonic/larval neuromuscular junction (with stj²)

stj¹

embryonic/larval neuromuscular junction (with stj³)

stj¹

embryonic/larval somatic muscle (with stj^DD106)

stj^k10814

embryonic/larval somatic muscle (with stj^k10814)

stj^DD106

stj^DD106

NMJ bouton | increased number (with Df(2R)Exel7128)

synapse (with Df(2R)Exel7128)

stj^DD106

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (5)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

15 of 15

Yes

Yes

13 of 15

No

Yes

5 of 15

No

Yes

4 of 15

No

Yes

1 of 15

No

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (5)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

15 of 15

Yes

Yes

12 of 15

No

Yes

4 of 15

No

Yes

4 of 15

No

Yes

1 of 15

No

No

Rattus norvegicus (Norway rat) (5)

12 of 13

Yes

Yes

8 of 13

No

Yes

4 of 13

No

Yes

3 of 13

No

Yes

1 of 13

No

No

Xenopus tropicalis (Western clawed frog) (5)

7 of 12

Yes

Yes

3 of 12

No

Yes

3 of 12

No

Yes

3 of 12

No

Yes

1 of 12

No

No

Danio rerio (Zebrafish) (9)

11 of 15

Yes

Yes

11 of 15

Yes

Yes

8 of 15

No

Yes

6 of 15

No

Yes

4 of 15

No

Yes

4 of 15

No

Yes

3 of 15

No

Yes

1 of 15

No

No

1 of 15

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

12 of 15

Yes

Yes

3 of 15

No

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900SS )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00006543

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500PJ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY002865

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_05936

Mayetiola destructor

Hessian fly

Mdes\Mdes001603

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL000121

Anopheles darlingi

American malaria mosquito

Adar\ADAC008799

Anopheles gambiae

Malaria mosquito

Agam\AGAP005490

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ005664

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0107 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA003639

Bombyx mori

Silkmoth

Bmor\BGIBMGA003640

Danaus plexippus

Monarch butterfly

Dple\DPOGS215762-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL014118

Apis florea

Little honeybee

Aflo\3877647348

Apis florea

Little honeybee

Aflo\2704346340

Apis mellifera

Western honey bee

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002723

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG006028

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG006025

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM308330

Pediculus humanus

Human body louse

Phum\PHUM308320

Rhodnius prolixus

Kissing bug

Rpro\RPRC013647

Rhodnius prolixus

Kissing bug

Rpro\RPRC015038

Cimex lectularius

Bed bug

Clec\CLEC013620

Cimex lectularius

Bed bug

Clec\CLEC008838

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005076

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI002652

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_10863

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_10864

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00YH )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR000568

Ixodes scapularis

Black-legged tick

Isca\ISCW019599

Stegodyphus mimosarum

African social velvet spider

Smim\KFM63763.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM63764.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM63765.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM63762.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM65775.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM74283.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM74284.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur28g00940

Tetranychus urticae

Two-spotted spider mite

Turt\tetur23g01660

Tetranychus urticae

Two-spotted spider mite

Turt\tetur23g01920

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_317041

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (4)

Gene Symbol

Score

Source

Alignment

6 of 10

4 of 10

3 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CACNA2D4; calcium voltage-gated channel auxiliary subunit alpha2delta 4

model of cone dystrophy

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CACNA2D3; calcium voltage-gated channel auxiliary subunit alpha2delta 3

15 of 15

CACNA2D4; calcium voltage-gated channel auxiliary subunit alpha2delta 4

13 of 15

RETINAL CONE DYSTROPHY 4; RCD4

cone dystrophy

CACNA2D1; calcium voltage-gated channel auxiliary subunit alpha2delta 1

5 of 15

CACNA2D2; calcium voltage-gated channel auxiliary subunit alpha2delta 2

4 of 15

CEREBELLAR ATROPHY WITH SEIZURES AND VARIABLE DEVELOPMENTAL DELAY; CASVDD

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

proximity ligation assay, fluorescence microscopy

(Hoover et al., 2019)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Kurshan et al., 2009, Dickman et al., 2008, Ly et al., 2008)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261041

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

36526

MIST (genetic) - An integrated Molecular Interaction Database

stj

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2R

Recombination map

2-68

Cytogenetic map

Sequence location

2R:13,805,794..13,819,571 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

50C5-50C6

Limits computationally determined from genome sequence between P{lacW}l(2)03105^k16702&P{lacW}fl(2)d^k16105 and P{lacW}shot^k03010

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

50C3-50C4

(determined by in situ hybridisation)

(Spradling et al., 1999)

50C3-50C4

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-68

(FlyBase, 2016)

2-73.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (15)

25807

y¹ v¹; P{TRiP.JF01825}attP2

34109

y¹ w^*; Mi{MIC}stj^MI00783/SM6a

11004

y¹ w^67c23; P{lacW}stj^k10814/CyO

14156

y¹ w^67c23; P{SUPor-P}stj^KG06941

39715

w¹¹¹⁸; P{neoFRT}42D stj²/CyO, P{sevRas1.V12}FK1

66781

y¹ w^*; Mi{Trojan-GAL4.0}stj^{MI00783-TG4.0}

39717

w^*; P{UAS-FLAG-stj-HA}2/CyO; In(3L)D, D¹/TM3, Sb¹

F001495

M{UAS-stj.ORF}ZH-86Fb

F001252

M{UAS-stj.ORF.3xHA}ZH-86Fb

102765

y¹ w^67c23 ; P{lacW}stj^k10814 / CyO

104034

y^* w^*; P{GawB}stj^NP1574 / CyO, P{UAS-lacZ.UW14}UW14

v108569

P{KK101267}VIE-260B

More stocks available...

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (37)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP15332

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261041

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261041

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

36526

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Kuromi et al., 2010)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: stj CG12295

(Ly, 2006.2.28)

Source for database merge of

Source for merge of: stj l(2)k10814

(Dickman et al., 2008)

Additional comments

Other Comments

stj mutant embryos display an arrest in neuromuscular junction morphogenesis rather than a delay of neuronal development.

(Kurshan et al., 2009)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 54 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36526

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261041

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261041

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

stj_1
stj_2

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12295

Flygut - An atlas of the Drosophila adult midgut

FBgn0261041

FlyMine - An integrated database for Drosophila genomics

FBgn0261041

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

36526

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG12295

modMine - A data warehouse for the modENCODE project

FBgn0261041

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261041

DRSC - Results frm RNAi screens

FBgn0261041

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0261041

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

36526

MIST (genetic) - An integrated Molecular Interaction Database

stj

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG12295

(Heinrich and Ryglewski, 2020, Meadows, 2019.11.20, Ghimire and Kim, 2015, Schertel et al., 2013, Christis and Munro, 2012, Tsubouchi et al., 2012, Ellis and Carney, 2011, Mosallanejad et al., 2010, Neely et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15, Dickman et al., 2008, Ly et al., 2008, Anantharaman and Aravind, 2000)

dα₂δ-3

(Kurshan et al., 2009, Dickman et al., 2008)

dα₂δ₃

(Heinrich and Ryglewski, 2020)

l(2)k10814

α₂δ

(Ly et al., 2008, Hoopengardner et al., 2003)

α₂δ-3

(Hoover et al., 2019, Kurshan et al., 2009)

Name Synonyms

Straightjacket

(Galili et al., 2014)

lethal (2) k10814

straight-jacket

(Khuong and Neely, 2013)

straightjacket

(Yu et al., 2016, Ghimire and Kim, 2015, Tsubouchi et al., 2012, Neely et al., 2011, Kuromi et al., 2010, Neely et al., 2010, Ly et al., 2008, Ly et al., 2008, Ly, 2006.2.28, Ly et al., 2006)

Secondary FlyBase IDs

FBgn0033870
FBgn0021940

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (68)