FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\stjJF01825
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General Information
Symbol
Dmel\stjJF01825
Species
D. melanogaster
Name
FlyBase ID
FBal0219834
Feature type
allele
Associated gene
Dmel\stj
Associated Insertion(s)
Carried in Construct
P{TRiP.JF01825}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009.1.15)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009.1.15)
Mutagen
in vitro construct
(Perkins et al., 2009.1.15)
Progenitor genotype
Carried in construct
P{TRiP.JF01825}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.1.15)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF01825
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  myotonic dystrophy type 1
      modeled by bru3d09837
      (Auxerre-Plantié et al., 2019)
      modeled by mblGD13374
      (Auxerre-Plantié et al., 2019)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of stjJF01825 under the control of Scer\GAL4ppk.PG leads to significantly slower heat nociception in third instar larvae; significant suppression of noxious escape behavior (jumping) in response to heated surface; and complete suppression of neuropathic sensitization after injury in adults when compared to controls.

      (Khuong et al., 2019)

      Adults expressing stjJF01825 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) show reduced avoidance of noxious temperature (46[o]C) compared to control flies. The kinetics of temperature induced paralysis at 46[o]C in these flies is comparable to that of control flies.

      Larvae expressing stjJF01825 under the control of Scer\GAL4elav.PLu show a severely impaired thermal nociception response compared to controls.

      (Neely et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of stjJF01825 and stolKK106795 under the control of Scer\GAL4GMR23H06 (in combination with a Dicer-2 transgene to enhance RNAi efficiency) leads to a reduction in the high voltage activated Ca2[+] current amplitude in pupal motor neurons.

      (Heinrich and Ryglewski, 2020)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      stjJF01825
      Name Synonyms
      Secondary FlyBase IDs
        References (8)