FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Ca-Ma2d
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General Information
Symbol
Dmel\Ca-Ma2d
Species
D. melanogaster
Name
Ca2+ channel Muscle-specific alpha2/delta subunit
Annotation Symbol
CG42817
Feature Type
protein_coding_gene
FlyBase ID
FBgn0261999
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

BG:DS07473.1

Key Links
Genomic Location
Cytogenetic map
35F1-35F1
Sequence location
Recombination map
2-52
RefSeq locus
NT_033779 REGION:16231475..16241527
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables voltage-gated calcium channel activity
inferred from biological aspect of ancestor with PANTHER:PTN000018330
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:Q7Z3S7
(Gene Ontology Curators, 2002-)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in calcium ion transmembrane transport
inferred from sequence or structural similarity with UniProtKB:Q7Z3S7
(Gene Ontology Curators, 2002-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in sarcoplasmic reticulum
inferred from direct assay
(Reuveny et al., 2018)
located_in T-tubule
inferred from direct assay
(Reuveny et al., 2018)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of voltage-gated calcium channel complex
inferred from biological aspect of ancestor with PANTHER:PTN000018330
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
VOLTAGE-GATED CALCIUM CHANNEL ACCESSORY SUBUNITS -
Voltage-gated Ca[2+] channels (CACN) allow the influx of extracellular Ca[2+] in response to plasma membrane depolarization. CACNs are hetero-oligomeric assemblies of a voltage-gated, pore-forming α1 subunit and accessory subunits that modulate channel activity. (Adapted from FBrf0218524 and PMID:21746798).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Ca-Ma2d for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q8IP22)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ca-Ma2d-RA
FBtr0303797
NM_165149
4919
1215
Ca-Ma2d-RB
FBtr0332356
NM_001273557
5790
1215
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Ca-Ma2d-PA
FBpp0292804
140.6
1215
4.85
Q8IP22
NP_723955
AAN10933
Ca-Ma2d-PB
FBpp0304633
140.6
1215
4.85
Q8IP22
NP_001260486
AGB93021
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1215 aa isoforms: Ca-Ma2d-PA, Ca-Ma2d-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ca-Ma2d using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.94

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
larval muscle system
(Reuveny et al., 2018)
larval muscle system
(Reuveny et al., 2018)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Wasbrough et al., 2010)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data

Ca-Ma2d protein localizes to the sarcoplasmic reticulum and T-tubules, and accumulates at the myonuclear membrane.

(Reuveny et al., 2018)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in sarcoplasmic reticulum
inferred from direct assay
(Reuveny et al., 2018)
located_in T-tubule
inferred from direct assay
(Reuveny et al., 2018)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ca-Ma2d in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ca-Ma2d
Transgenic constructs containing regulatory region of Ca-Ma2d
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (13)
Hsap\CACNA2D4
10 of 14
Yes
No
Hsap\CACNA2D3
9 of 14
No
No
Hsap\CACNA2D1
6 of 14
No
No
Hsap\CACNA2D2
6 of 14
No
Yes
Hsap\CACHD1
1 of 14
No
No
Hsap\ITIH1
1 of 14
No
Yes
Hsap\ITIH2
1 of 14
No
Yes
Hsap\ITIH3
1 of 14
No
Yes
Hsap\ITIH4
1 of 14
No
Yes
Hsap\ITIH5
1 of 14
No
Yes
Hsap\ITIH6
1 of 14
No
Yes
Hsap\MATN1
1 of 14
No
No
Hsap\VWA5B1
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (11)
Rnor\Cacna2d3
9 of 14
Yes
No
Rnor\Cacna2d4
9 of 14
Yes
No
Rnor\Cacna2d2
6 of 14
No
Yes
Rnor\Cacna2d1
5 of 14
No
Yes
Rnor\Cachd1
2 of 14
No
No
Rnor\Col6a1
1 of 14
No
Yes
Rnor\Itih1
1 of 14
No
Yes
Rnor\Itih2
1 of 14
No
Yes
Rnor\Itih3
1 of 14
No
Yes
Rnor\Itih4
1 of 14
No
Yes
Rnor\Vwa5b1
1 of 14
No
Yes
Mus musculus (laboratory mouse) (14)
Mmus\Cacna2d3
9 of 14
Yes
No
Mmus\Cacna2d4
8 of 14
No
No
Mmus\Cacna2d2
6 of 14
No
Yes
Mmus\Cacna2d1
5 of 14
No
No
Mmus\Cachd1
2 of 14
No
No
Mmus\Col6a1
1 of 14
No
Yes
Mmus\Col6a4
1 of 14
No
Yes
Mmus\Itih1
1 of 14
No
Yes
Mmus\Itih2
1 of 14
No
Yes
Mmus\Itih3
1 of 14
No
Yes
Mmus\Itih4
1 of 14
No
Yes
Mmus\Itih5
1 of 14
No
Yes
Mmus\Matn1
1 of 14
No
Yes
Mmus\Vwa5b1
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (7)
Xtro\cacna2d1
5 of 13
Yes
Yes
Xtro\cacna2d2
5 of 13
Yes
Yes
Xtro\cacna2d4
5 of 13
Yes
No
Xtro\cacna2d3
4 of 13
No
No
Xtro\cachd1
1 of 13
No
No
Xtro\itih2
1 of 13
No
No
Xtro\rtf2
1 of 13
No
No
Danio rerio (Zebrafish) (18)
Drer\cacna2d3
9 of 14
Yes
No
Drer\cacna2d4b
9 of 14
Yes
No
Drer\cacna2d3a
8 of 14
No
No
Drer\cacna2d1a
7 of 14
No
Yes
Drer\cacna2d2b
7 of 14
No
Yes
Drer\cacna2d1
6 of 14
No
Yes
Drer\cacna2d4a
6 of 14
No
No
Drer\cacna2d2a
4 of 14
No
Yes
Drer\cachd1
2 of 14
No
No
Drer\itih2
1 of 14
No
Yes
Drer\itih3a.1
1 of 14
No
Yes
Drer\itih3a.2
1 of 14
No
Yes
Drer\itih3b.1
1 of 14
No
Yes
Drer\itih3b.2
1 of 14
No
Yes
Drer\itih5
1 of 14
No
Yes
Drer\itih6
1 of 14
No
Yes
Drer\matn3a
1 of 14
No
Yes
Drer\vwa5b2
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\unc-36
11 of 14
Yes
Yes
Cele\tag-180
4 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (4)
Agam\AgaP_AGAP009579
12 of 12
Yes
Yes
Agam\AgaP_AGAP009598
6 of 12
No
No
Agam\AgaP_AGAP005490
4 of 12
No
No
Agam\AgaP_AGAP009043
2 of 12
No
No
Arabidopsis thaliana (thale-cress) (10)
Atha\AT2G38970
2 of 13
Yes
Yes
Atha\AT1G08050
1 of 13
No
Yes
Atha\AT1G19110
1 of 13
No
Yes
Atha\AT1G72500
1 of 13
No
Yes
Atha\AT3G54780
1 of 13
No
Yes
Atha\AT5G49665
1 of 13
No
Yes
Atha\AT5G60710
1 of 13
No
Yes
Atha\EDA40
1 of 13
No
Yes
Atha\WAVH1
1 of 13
No
Yes
Atha\WAVH2
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (1)
Ecol\yfbK
1 of 11
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Ca-Ma2d. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (4)
stj
10 of 13
stol
10 of 13
CG16868
3 of 13
CG42818
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 2 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CACNA2D4; calcium voltage-gated channel auxiliary subunit alpha2delta 4
    10 of 14
    608171
    CACNA2D3; calcium voltage-gated channel auxiliary subunit alpha2delta 3
    9 of 14
    606399
        CACNA2D1; calcium voltage-gated channel auxiliary subunit alpha2delta 1
        6 of 14
        114204
        CACNA2D2; calcium voltage-gated channel auxiliary subunit alpha2delta 2
        6 of 14
        607082
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          Ca-Ma2d - Amph
          anti tag coimmunoprecipitation, western blot
          (Reuveny et al., 2018)
          Summary of Genetic Interactions
          Interaction Browsers
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          External Data
          Linkouts
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          FlyBase
          External Links
          Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
          External Data
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2L
          Recombination map
          2-52
          Cytogenetic map
          35F1-35F1
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          35F1-35F1
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location

          2-52

          (FlyBase, 2016)

          2-49.3

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes

          Gene order: In direction of increasing cytology: CG31819+ CG12455+ PRL-1-

          (Ashburner et al., 1999)
          Stocks and Reagents
          Stocks (8)
          Genomic Clones (25)
          cDNA Clones (14)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             

            monoclonal

            (Reuveny et al., 2018)

            polyclonal

            (Reuveny et al., 2018)
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments
                Relationship to Other Genes
                Source for database merge of

                Source for merge of: BG:DS07473.1 CG12455

                (Bayraktaroglu, 2000.4.8)

                Source for merge of: CG12455 anon-WO0138359.9

                (FlyBase, 1996-)
                Additional comments

                Source for split of: CG12455

                (FlyBase Genome Annotators, 2010)

                Annotation CG12455 split into CG42817 and CG42818 in release 5.30 of the genome annotation.

                (FlyBase Genome Annotators, 2010)

                Source for merge of CG12455 anon-WO0138359.9 was sequence comparison ( date:051113 ).

                (FlyBase, 1996-)
                Nomenclature History
                Source for database identify of

                Source for identity of: Ca-Ma2d CG42817

                (Reuveny et al., 2018)
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (9)
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 33 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DRSC - Results frm RNAi screens
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                References (41)