FlyBase Gene Report: Dmel\SLO2

General Information

Symbol

Dmel\SLO2

Species

D. melanogaster

Name

slowpoke 2

Annotation Symbol

CG42732

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261698

Gene Model Status

Current

Stock Availability

29 publicly available

Gene Summary

slowpoke 2 (SLO2) encodes a channel involved in potassium ion transmembrane transport. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Dm_2R:24438 , Dm_2R:24301

Key Links

Genomic Location

Cytogenetic map

47A1-47A7

Sequence location

2R:10,322,195..10,416,996 [-]

Recombination map

2-62

RefSeq locus

NT_033778 REGION:10322195..10416996

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables intracellular sodium-activated potassium channel activity

inferred from direct assay

(Budelli et al., 2016)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables calcium-activated potassium channel activity

inferred from sequence or structural similarity with FLYBASE:slo; FB:FBgn0003429

(Gene Ontology Curators, 2002-)

enables intracellular sodium-activated potassium channel activity

inferred from biological aspect of ancestor with PANTHER:PTN000798363

(GO Reference Genome Project, 2011-)

enables outward rectifier potassium channel activity

inferred from biological aspect of ancestor with PANTHER:PTN000798363

(GO Reference Genome Project, 2011-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in potassium ion transmembrane transport

inferred from direct assay

(Budelli et al., 2016)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in potassium ion transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN004121346

(GO Reference Genome Project, 2011-)

involved_in potassium ion transport

inferred from electronic annotation with InterPro:IPR003148, InterPro:IPR003929

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with FLYBASE:slo; FB:FBgn0003429

(Gene Ontology Curators, 2002-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from sequence or structural similarity with FLYBASE:slo; FB:FBgn0003429

(Gene Ontology Curators, 2002-)

inferred from electronic annotation with InterPro:IPR003929

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000798363

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

SODIUM AND VOLTAGE-ACTIVATED LARGE CONDUCTANCE POTASSIUM CHANNELS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

slowpoke 2 (SLO2) encodes a channel involved in potassium ion transmembrane transport. [Date last reviewed: 2019-08-01]

Gene Group (FlyBase)

SODIUM AND VOLTAGE-ACTIVATED LARGE CONDUCTANCE POTASSIUM CHANNELS -: Large conductance sodium and voltage-active potassium channels are homotetrameric transmembrane potassium channels activated independently by intracellular calcium and/or voltage. (Adapted from PMID:38561252 and FBrf0193525.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\SLO2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A8DY93)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene merge and split/merge based on RNAseq data.

Gene model reviewed during 5.44

Double stop-codon suppression (UGA, UAG) postulated; FBrf0216884.

Gene model reviewed during 5.48

A non-AUG start codon may be used for translation of one or more transcripts of this gene; based on the presence of conserved protein signatures within the 5' UTR without an in-frame AUG (FBrf0243886).

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

SLO2-RD

FBtr0303080

NM_001103789

6920

1878

SLO2-RE

FBtr0303081

NM_001103788

6608

1774

SLO2-RF

FBtr0303082

NM_001201971

6904

1788

SLO2-RG

FBtr0303083

NM_001201972

7121

1707

SLO2-RH

FBtr0305946

NM_001259313

6314

1438

SLO2-RI

FBtr0329869

NM_001273932

7121

1742

SLO2-RL

FBtr0329872

NM_001273933

6559

1624

SLO2-RN

FBtr0329938

NM_001273934

7234

1732

SLO2-RO

FBtr0330616

NM_001273935

7121

1727

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

SLO2-PD

FBpp0292199

205.3

1878

7.43

FBpp0292200

194.6

1774

7.54

FBpp0292201

196.4

1788

7.81

FBpp0292202

187.2

1707

7.42

FBpp0297088

159.4

1438

7.03

FBpp0302905

191.5

1742

7.88

FBpp0302908

178.0

1624

7.13

FBpp0302970

190.2

1732

7.72

FBpp0303466

189.7

1727

7.72

A0A0B4KEJ9

NP_001260864

AGB93397

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SLO2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.78

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\SLO2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\SLO2

View exonic expression by tissue for Dmel\SLO2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

5740325/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261698

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261698

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12901

Flygut - An atlas of the Drosophila adult midgut

FBgn0261698

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 20 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of SLO2

Transgenic constructs containing regulatory region of SLO2

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^insc-Mz1407

SLO2^GD7860

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

SLO2^GD7860

partially lethal - majority die, with Scer\GAL4^pnr-MD237

SLO2^GD7860

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

SLO2^GD3495

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Other Phenotypes

Allele

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

SLO2^GD7860

abnormal neurophysiology

SLO2^CRISPR

some die during pupal stage, with Scer\GAL4^pnr-MD237

SLO2^GD7860

visible, with Scer\GAL4^pnr-MD237

SLO2^GD7860

Phenotype manifest in

Allele

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

SLO2^GD7860

mesonotum, with Scer\GAL4^pnr-MD237

SLO2^GD7860

trichogen cell, with Scer\GAL4^pnr-MD237

SLO2^GD7860

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (20)

Hsap\KCNT1

14 of 14

Yes

Hsap\KCNT2

13 of 14

Yes

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (9)

Rnor\Kcnt1

14 of 14

Yes

Rnor\Kcnt2

13 of 14

Yes

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (10)

Mmus\Kcnt1

14 of 14

Yes

Mmus\Kcnt2

12 of 14

Yes

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (14)

Xtro\kcnt2l

7 of 13

Yes

Xtro\kcnt2

6 of 13

Yes

Xtro\kcnt1

2 of 13

Yes

Xtro\kiaa0319l

2 of 13

Xtro\fcsk

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\kcnk13

1 of 13

Yes

Xtro\kcnk16

1 of 13

Xtro\plekhg4

1 of 13

Danio rerio (Zebrafish) (12)

Drer\kcnt1a

14 of 14

Yes

Drer\kcnt1b

12 of 14

Yes

Drer\LOC565691

12 of 14

Yes

Drer\kcnt2

4 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (25)

Cele\slo-2

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (8)

Agam\AgaP_AGAP007585

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (6)

Atha\KCO1

1 of 13

Yes

Atha\KCO2

1 of 13

Yes

Atha\KCO3

1 of 13

Yes

Atha\KCO5

1 of 13

Yes

Atha\KCO6

1 of 13

Yes

Atha\TPK4

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\TOK1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:SLO2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (6)

slo

3 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

seizure-sensitive, potassium channel defects, KCNT1-2-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

SLO2^DN.UAS

model of epilepsy

CEA

(Byers et al., 2021)

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

KCNT1; potassium sodium-activated channel subfamily T member 1

model of developmental and epileptic encephalopathy 14

IEA

(FlyBase, 2019-)

model of autosomal dominant nocturnal frontal lobe epilepsy 5

IEA

(FlyBase, 2019-)

KCNT2; potassium sodium-activated channel subfamily T member 2

model of developmental and epileptic encephalopathy 57

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

SLO2^MB04544

exacerbates nervous system disease

modeled by Atpα^DTS1

(Talsma et al., 2014)

SLO2^CRISPR

exacerbates epilepsy

modeled by para^GEFS+

(Byers et al., 2021)

modeled by jus^iso7.8

(Byers et al., 2021)

modeled by para^bss1

(Byers et al., 2021)

modeled by eas²

(Byers et al., 2021)

SLO2^DN.UAS

exacerbates epilepsy

modeled by jus^iso7.8

(Byers et al., 2021)

modeled by para^bss1

(Byers et al., 2021)

modeled by eas²

(Byers et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

KCNT1; potassium sodium-activated channel subfamily T member 1

14 of 14

POTASSIUM CHANNEL, SUBFAMILY T, MEMBER 1; KCNT1

KCNT2; potassium sodium-activated channel subfamily T member 2

13 of 14

610044

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 57; DEE57

developmental and epileptic encephalopathy 57

KCNU1; potassium calcium-activated channel subfamily U member 1

3 of 14

615215

SPERMATOGENIC FAILURE 79; SPGF79

spermatogenic failure 79

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

eas

enhanceable

SLO2

(Byers et al., 2021)

jus

enhanceable

SLO2

(Byers et al., 2021)

para

enhanceable

SLO2

(Byers et al., 2021)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261698

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

(FlyBase Genome Annotators, 2010)

protein_coding_gene

(FlyBase Genome Annotators, 2010)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-62

Cytogenetic map

47A1-47A7

Sequence location

2R:10,322,195..10,416,996 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

47A1-47A7

Limits computationally determined from genome sequence between P{lacW}Hr46^k10308 and P{PZ}lola⁰⁰³⁴⁹&P{EP}lola^EP952

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-62

(FlyBase, 2016)

2-61.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (29)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

72957

w¹¹¹⁸; P{VT014554-p65.AD}attP40

74181

w¹¹¹⁸; P{VT014561-p65.AD}attP40

74239

w¹¹¹⁸; P{VT014567-p65.AD}attP40

74175

w¹¹¹⁸; P{VT014554-GAL4.DBD}attP2

74176

w¹¹¹⁸; P{VT014561-GAL4.DBD}attP2

24791

w¹¹¹⁸; Mi{ET1}SLO2^MB04544

32034

y¹ v¹; P{TRiP.JF03426}attP2

Korea

15065

P{VT014554-GAL4}attP2

15066

P{VT014561-GAL4}attP2

15067

P{VT014567-GAL4}attP2

VDRC

v10268

w¹¹¹⁸; P{GD3495}v10268

v40698

w¹¹¹⁸; P{GD13019}v40698

More stocks available...

Genomic Clones (63)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (14)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261698

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261698

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG12904 CG12899

(FlyBase Genome Annotators, 2007)

Additional comments

Annotations CG12897, CG34363 and the first exon of CG12901-RA have been merged as a single annotation, CG42732, in release 5.27 of the genome annotation. The second exon of CG12901-RA has been split out into a separate annotation, CG42733, in release 5.27 of the genome annotation.

(FlyBase Genome Annotators, 2010)

Annotations CG12904 and CG12899 merged as CG34363 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Nomenclature History

Source for database identify of

Source for identity of: SLO2 CG42732

(Budelli et al., 2016)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

CG12897

(Ashwal-Fluss et al., 2014, Strub et al., 2008)

CG12899

(Strub et al., 2008, Lawniczak and Begun, 2004)

CG12901

(Strub et al., 2008, Giot et al., 2003)

CG12904

(Sepp et al., 2008, Strub et al., 2008, Cardoso et al., 2006, Wang et al., 2004)

CG34363

(Ashwal-Fluss et al., 2014, Rodriguez et al., 2012, Tsubouchi et al., 2012, Jungreis et al., 2011, FlyBase Genome Annotators, 2007)

CG42732

(National Institute of Genetics Fly Stocks, 2023-, National Institute of Genetics Fly Stocks, 2022-, Walcott et al., 2018, Budelli et al., 2016, Gene Disruption Project members, 2015-, Talsma et al., 2014, Rodriguez et al., 2012, Ni et al., 2010.12.1, Perkins et al., 2009)

Dm_2R:24301

(FlyBase Genome Annotators, 2014, Ladoukakis et al., 2011)

Dm_2R:24438

(FlyBase Genome Annotators, 2014, Ladoukakis et al., 2011)

SLO2

(Corthals et al., 2023, Voutyraki et al., 2023, Kumar et al., 2021, Scaplen and Petruccelli, 2021, Takai et al., 2020, Campbell et al., 2019, FlyBase Genome Annotators, 2019-, Meltzer et al., 2019, Du et al., 2018, Wang et al., 2018)

Slack

(McCormack, 2003)

Slo2

(Bossen et al., 2023)

dSLO2

(Budelli et al., 2016)

dSlo2

(Byers et al., 2021)

Name Synonyms

CG12899

CG12904

slowpoke 2

Secondary FlyBase IDs

FBgn0261685
FBgn0085392
FBgn0033510
FBgn0040771
FBgn0033517
FBgn0033513

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 62 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

5740325

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A8DY93

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A8DY93

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

5740325/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261698

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261698

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG42732

MARRVEL_MODEL - MARRVEL (model organism gene)

5740325

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261698

DroID - A comprehensive database of gene and protein interactions.

FBgn0261698

DRSC - Results frm RNAi screens

FBgn0261698

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261698

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12901

Flygut - An atlas of the Drosophila adult midgut

FBgn0261698

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC032248

References (69)

The following external sites may use different assemblies or annotations than FlyBase.

-0.78

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