FlyBase Gene Report: Dmel\SK

General Information

Symbol

Dmel\SK

Species

D. melanogaster

Name

small conductance calcium-activated potassium channel

Annotation Symbol

CG10706

Feature Type

protein_coding_gene

FlyBase ID

FBgn0029761

Gene Model Status

Current

Stock Availability

71 publicly available

Gene Summary

small conductance calcium-activated potassium channel (SK) encodes a potassium channel subunit. Four SK subunits together form a voltage-independent potassium channel, which is activated by intracellular calcium levels and is required for normal photoreceptor light response. Contrary to its mammalian counterpart, Drosophila SK channel is not sensitive to apamin, at least not in photoreceptors. [Date last reviewed: 2023-01-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dSK

Key Links

Genomic Location

Cytogenetic map

4F5-4F9

Sequence location

X:5,340,236..5,405,138 [+]

Recombination map

1-11

RefSeq locus

NC_004354 REGION:5340236..5405138

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables photoreceptor activity

inferred from direct assay

(Abou Tayoun et al., 2011)

enables small conductance calcium-activated potassium channel activity

inferred from direct assay

(Abou Tayoun et al., 2011)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables calcium-activated potassium channel activity

inferred from electronic annotation with InterPro:IPR004178, InterPro:IPR036122

(InterPro Project Members, 2004-)

enables calmodulin binding

inferred from biological aspect of ancestor with PANTHER:PTN000016262

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR004178, InterPro:IPR036122

(InterPro Project Members, 2004-)

enables small conductance calcium-activated potassium channel activity

inferred from biological aspect of ancestor with PANTHER:PTN000016262

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR015449

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with UniProtKB:P70604

(Gene Ontology Curators, 2002-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in potassium ion transport

inferred from mutant phenotype

(Abou Tayoun et al., 2011)

involved_in regulation of membrane potential in photoreceptor cell

inferred from direct assay

(Abou Tayoun et al., 2011)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in potassium ion transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN001299629

(GO Reference Genome Project, 2011-)

involved_in potassium ion transport

inferred from electronic annotation with InterPro:IPR004178, InterPro:IPR015449, InterPro:IPR036122

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR015449

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with UniProtKB:P70604

(Gene Ontology Curators, 2002-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in membrane

inferred from direct assay

(Abou Tayoun et al., 2011)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR004178, InterPro:IPR015449, InterPro:IPR036122

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR015449

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with UniProtKB:P70604

(Gene Ontology Curators, 2002-)

is_active_in neuron projection

inferred from biological aspect of ancestor with PANTHER:PTN000016263

(GO Reference Genome Project, 2011-)

is_active_in neuronal cell body

inferred from biological aspect of ancestor with PANTHER:PTN000016263

(GO Reference Genome Project, 2011-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000016262

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS

Protein Family (UniProt)

Belongs to the potassium channel KCNN family. SK subfamily. (Q7KVW5)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS -: Small conductance calcium-activated potassium channels are voltage-independent homotetrameric transmembrane channels specific for potassium and activated by intracellular calcium via interaction with calmodulin. (Adapted from FBrf0216279.)

Protein Function (UniProtKB)

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).

(UniProt, Q7KVW5)

Summary (Interactive Fly)

potassium channel - negatively regulates nociception - interacts with calmodulin, which acts as a Ca2+ sensor - regulates synaptic excitation in the visual network - postsynapse of the NMJ - contributes to photoreceptor performance by mediating sensitivity control at the first negatively regulates the acquisition of short-term memory

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\SK for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7KVW5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.55

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Gene model reviewed during 5.54

Gene model reviewed during 5.56

Stop-codon suppression (UGA) postulated; FBrf0225455.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

SK-RH

FBtr0300467

NM_167032

3729

524

SK-RI

FBtr0301949

NM_167030

3723

522

SK-RJ

FBtr0301950

NM_167031

3556

812

SK-RK

FBtr0301951

NM_167029

4813

927

SK-RL

FBtr0301952

NM_080339

3885

576

SK-RM

FBtr0301953

NM_206631

8828

927

SK-RN

FBtr0301954

NM_001103415

3484

685

SK-RO

FBtr0331602

NM_001272322

4946

960

SK-RP

FBtr0331603

NM_001272323

8050

979

SK-RQ

FBtr0331604

NM_001272324

5179

928

SK-RR

FBtr0344555

NM_001297957

3729

719

SK-RS

FBtr0344556

NM_001297958

8050

1174

SK-RT

FBtr0344557

NM_001297959

3885

771

SK-RU

FBtr0344558

NM_001297960

4813

1122

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

SK-PH

FBpp0289694

59.5

524

9.77

NP_726989

AAF46027

SK-PI

FBpp0291161

59.4

522

9.53

NP_726987

AAN09137

SK-PJ

FBpp0291162

88.6

812

9.63

NP_726988

AAF46029

SK-PK

FBpp0291163

101.9

927

9.34

FBpp0291164

65.1

576

9.63

NP_525078

AAF46030

SK-PM

FBpp0291165

101.8

927

9.47

NP_996354

AAS65264

SK-PN

FBpp0291166

76.6

685

9.77

NP_001096885

ABX11900

SK-PO

FBpp0303992

105.5

960

9.78

FBpp0303993

107.2

979

9.63

FBpp0303994

101.8

928

9.55

FBpp0310908

80.5

719

9.80

FBpp0310909

128.1

1174

9.66

FBpp0310910

86.0

771

9.67

FBpp0310911

122.8

1122

9.40

X2JAI8

NP_001284889

AHN59360

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).

(UniProt, Q7KVW5)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SK using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

SK_1
SK_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.77

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

sensory system neuron

• axon

(Walcott et al., 2018)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

SK protein is strongly expressed in the adult lamina and medulla layers. In the lamina, is localises to the axons of the photoreceptors, the cell body of non-glutamatergic neurons, (possibly L4) and in the presynaptic active zones. In the medulla, it is detected in glutamatergic and non-glutamatergic neurons. Expression seems strongest in medulla layers M4 and M5. In the central brain, SK protein is expressed by the olfactory projection neurons that innervate the mushroom bodies.

(Abou Tayoun et al., 2011)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in membrane

inferred from direct assay

(Abou Tayoun et al., 2011)

Expression Deduced from Reporters

Reporter: Mi{MIC}SK^MI10378

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

eo neuron | subset

(Walcott et al., 2018)

multidendritic neuron | subset

(Walcott et al., 2018)

larval multidendritic class IV neuron

(Walcott et al., 2018)

Reporter: TI{TI}SK^Tag:V5

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

eo neuron | subset

(Walcott et al., 2018)

multidendritic neuron | subset

(Walcott et al., 2018)

larval multidendritic class IV neuron

• axon

(Walcott et al., 2018)

abdominal anterior ventral multidendritic neuron vdaa

• axon

(Walcott et al., 2018)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\SK in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\SK

View exonic expression by tissue for Dmel\SK

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0029761

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31456/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0029761

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0029761

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0029761

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10706

Flygut - An atlas of the Drosophila adult midgut

FBgn0029761

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 23 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of SK

Transgenic constructs containing regulatory region of SK

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 11 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal immune response

abnormal locomotor behavior | larval stage, with Scer\GAL4^109(2)80

SK^KK107699

abnormal locomotor behavior | larval stage, with Scer\GAL4^ppk.1.9

SK^KK107699

abnormal locomotor behavior | larval stage | semidominant

SK^Δ

abnormal neuroanatomy, with Scer\GAL4²²¹

abnormal neurophysiology

SK¹

abnormal neurophysiology, with Scer\GAL4^GMR.long

SK^{DN.UAS.Tag:MYC}

Phenotype manifest in

Allele

abdominal dorsal multidendritic neuron ddaD | third instar larval stage, with Scer\GAL4²²¹

abdominal dorsal multidendritic neuron ddaE | third instar larval stage, with Scer\GAL4²²¹

dendritic tree | third instar larval stage, with Scer\GAL4²²¹

photoreceptor neuron

SK¹

photoreceptor neuron, with Scer\GAL4^GMR.long

SK^{DN.UAS.Tag:MYC}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (14)

Hsap\KCNN1

12 of 14

Yes

Hsap\KCNN2

12 of 14

Yes

Hsap\KCNN3

12 of 14

Yes

Hsap\KCNN4

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (13)

Rnor\Kcnn1

12 of 14

Yes

Rnor\Kcnn2

12 of 14

Yes

Rnor\Kcnn3

12 of 14

Yes

Rnor\Kcnn4

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (14)

Mmus\Kcnn2

13 of 14

Yes

Mmus\Kcnn1

11 of 14

Yes

Mmus\Kcnn3

11 of 14

Yes

Mmus\Kcnn4

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (10)

Xtro\kcnn1

8 of 13

Yes

Xtro\kcnn2

7 of 13

Yes

Xtro\kcnn4

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\kcnq1

1 of 13

Xtro\kpna4

1 of 13

Xtro\slc43a1

1 of 13

Yes

Danio rerio (Zebrafish) (20)

Drer\kcnn1a

13 of 14

Yes

Drer\kcnn2

12 of 14

Yes

Drer\kcnn3

12 of 14

Yes

Drer\kcnn1b

11 of 14

Yes

Drer\kcnn4

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\kcnl-2

11 of 14

Yes

Cele\kcnl-1

6 of 14

Yes

Cele\kcnl-3

6 of 14

Yes

Cele\kcnl-4

4 of 14

Yes

Cele\kqt-3

1 of 14

Cele\shl-1

1 of 14

Anopheles gambiae (African malaria mosquito) (4)

Agam\AgaP_AGAP010503

11 of 12

Yes

Agam\AgaP_AGAP010506

2 of 12

Yes

Agam\AgaP_AGAP005925

1 of 12

Agam\AgaP_AGAP006347

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:SK. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

Shab

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

KCNN2; potassium calcium-activated channel subfamily N member 2

model of myoclonic dystonia 34

IEA

(FlyBase, 2019-)

KCNN4; potassium calcium-activated channel subfamily N member 4

model of dehydrated hereditary stomatocytosis 2

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

SK^d03336

exacerbates childhood spinal muscular atrophy

modeled by Smn^73Ao

(Chang et al., 2008)

SK^MI09020

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 1

modeled by Zzzz\GGGGCC^36.UAS

(Castelli et al., 2021)

SK^MI10378

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 1

modeled by Zzzz\GGGGCC^36.UAS

(Castelli et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

KCNN1; potassium calcium-activated channel subfamily N member 1

12 of 14

602982

KCNN2; potassium calcium-activated channel subfamily N member 2

12 of 14

605879

myoclonic dystonia 34

KCNN3; potassium calcium-activated channel subfamily N member 3

12 of 14

602983

ZIMMERMANN-LABAND SYNDROME 3; ZLS3

KCNN4; potassium calcium-activated channel subfamily N member 4

4 of 14

602754

DEHYDRATED HEREDITARY STOMATOCYTOSIS 2; DHS2

dehydrated hereditary stomatocytosis 2

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).

(UniProt, Q7KVW5 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0029761

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Ca2+ activated K+ channels

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011, Stapleton et al., 2006)

gene_with_stop_codon_read_through

(FlyBase Genome Annotators, 2014)

nuclear_gene

(FlyBase Genome Annotators, 2014)

protein_coding_gene

(FlyBase Genome Annotators, 2014)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-11

Cytogenetic map

4F5-4F9

Sequence location

X:5,340,236..5,405,138 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

4F5-4F9

Limits computationally determined from genome sequence between P{EP}EP425 and P{EP}CG3249^EP1400

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-11

(FlyBase, 2016)

1-13.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (71)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Korea

11992

P{VT057248-GAL4}attP2

12244

P{VT057230-GAL4}attP2

12245

P{VT057231-GAL4}attP2

12246

P{VT057241-GAL4}attP2

12247

P{VT057245-GAL4}attP2

12538

P{VT057239-GAL4}attP2

13232

P{VT057252-GAL4}attP2

10706R-1

10706R-2

v103985

v200970

P{VT057244-GAL4}attP2

v200972

P{VT057247-GAL4}attP2

More stocks available...

Genomic Clones (35)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (15)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0029761

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0029761

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Abou Tayoun et al., 2011)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: SK CG10706 CG4179

(McCaman, 2001.3.12)

Source for merge of: SK BcDNA:GM01744

(FlyBase, 1996-)

Source for merge of: SK CG12733

(FlyBase, 1996-)

Additional comments

Source for merge of SK BcDNA:GM01744 was a shared cDNA ( date:020730 ).

(FlyBase, 1996-)

Source for merge of SK CG12733 was a shared cDNA ( date:010720 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

BcDNA:GM01744

CG10706

(Walcott et al., 2018, Qurashi et al., 2012, Tsubouchi et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Chang et al., 2008, Wang et al., 2004)

CG12733

CG4179

(Wang et al., 2004)

(Yoshino et al., 2025, Li et al., 2024, Corthals et al., 2023, George et al., 2023, Perlegos et al., 2023, Deshpande et al., 2022, Maksymchuk et al., 2022, Byers et al., 2021, Castelli et al., 2021, Dow et al., 2021, McLaughlin et al., 2021, Scaplen and Petruccelli, 2021, Wang et al., 2021, Perry et al., 2020, Meltzer et al., 2019, Gene Disruption Project members, 2018-, Hall et al., 2018, Li et al., 2018, Walcott et al., 2018, Wang et al., 2018, Onodera et al., 2017, Sharma et al., 2017, Transgenic RNAi Project members, 2017-, Kern et al., 2015, Ma et al., 2015, Pan et al., 2015, Ashwal-Fluss et al., 2014, FlyBase Genome Annotators, 2014, Westholm et al., 2014, Wolfram et al., 2014, Chow et al., 2013, Hattori et al., 2013, Sen et al., 2013, Zhang et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Qurashi et al., 2012, Rodriguez et al., 2012, Tsubouchi et al., 2012, Buffin and Gho, 2010, Sénatore et al., 2010, Perkins et al., 2009.8.10, Chang et al., 2008, Aerts et al., 2007, Junion et al., 2007, Stapleton et al., 2006, Blow et al., 2005, Glazov et al., 2005, McCormack, 2003)

(Raun et al., 2021, Blow et al., 2005)

dSK

(Gertner et al., 2014, Abou Tayoun et al., 2012, Abou Tayoun et al., 2011, Nolazco et al., 2001)

Name Synonyms

small conductance calcium-activated potassium channel

(Tsubouchi et al., 2012, Buffin and Gho, 2010, Chang et al., 2008, Glazov et al., 2005, Nolazco et al., 2001)

Secondary FlyBase IDs

FBgn0029758
FBgn0029760
FBgn0062493

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 106 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31456

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7KVW5

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q7KVW5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7KVW5

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0029761

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31456/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0029761

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0029761

FlyMine - An integrated database for Drosophila genomics

FBgn0029761

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG10706

MARRVEL_MODEL - MARRVEL (model organism gene)

31456

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0029761

DroID - A comprehensive database of gene and protein interactions.

FBgn0029761

DRSC - Results frm RNAi screens

FBgn0029761

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

SK_1
SK_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0029761

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0029761

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10706

Flygut - An atlas of the Drosophila adult midgut

FBgn0029761

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0029761

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014196

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Ca2+ activated K+ channels

References (103)

The following external sites may use different assemblies or annotations than FlyBase.

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