FlyBase Allele Report: Dmel\Dop2R[GD732]

General Information

Symbol

Dmel\Dop2R^GD732

Species

D. melanogaster

Name

FlyBase ID

FBal0206800

Feature type

allele

Associated gene

Dmel\Dop2R

Associated Insertion(s)

Carried in Construct

P{GD732}

Also Known As

UAS-Dop2R-RNAi, UAS-Dop2RRNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD732}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD732

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of alcohol use disorder

CEA

(Petruccelli et al., 2018)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Al-Ramahi et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal memory | adult stage, with Scer\GAL4^GH146

(Zhou et al., 2019)

abnormal memory | adult stage, with Scer\GAL4^NP2631

(Zhou et al., 2019)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Dop2R^GD732 under the control of Scer\GAL4^GH146 or Scer\GAL4^NP2631, but not Scer\GAL4^NP0225, significantly reduces short term aversive olfactory memory in adults, compared to controls; in the case of expression in Scer\GAL4^GH146 cells, this memory reduction is also observed when expression is restricted to the adult stage using a Gal80[ts] transgene.

(Zhou et al., 2019)

Expression of Dop2R^GD732 driven by Scer\GAL4^GMR23E10 does not significantly affect sleep amount per day, compared to controls.

(Pimentel et al., 2016)

Adults expressing Dop2R^GD732 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Dop2R^GD732, Scer\GAL4^GH146 has abnormal memory | adult stage phenotype, suppressible by Gad1^GD8508, Scer\GAL4^GH146

(Zhou et al., 2019)

Dop2R^GD732, Scer\GAL4^NP2631 has abnormal memory | adult stage phenotype, suppressible by Gad1^GD8508, Scer\GAL4^NP2631

(Zhou et al., 2019)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v11471

w¹¹¹⁸; P{GD732}v11471

v11470

w¹¹¹⁸; P{GD732}v11470/TM3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

D2R^GD732

(Al-Ramahi et al., 2018)

Dop2R^GD732

Name Synonyms

Secondary FlyBase IDs

References (19)

Report Sections

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