FlyBase Allele Report: Scer\GAL4[NP1131]

Labels a set of 25 embryonic-born gamma neurons on the surface layer of the third instar larvae mushroom body and is already visible at the first instar larval stage.

(Pauls et al., 2010)

Marker for

adult mushroom body gamma-lobe

(Mao and Davis, 2009)

Reflects expression of

ChAT

(Martín-Peña et al., 2014)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal chemosensory behavior | third instar larval stage, with ChT^JF03028

(Hamid et al., 2021)

abnormal chemosensory behavior | third instar larval stage, with ChT^KK109385

(Hamid et al., 2021)

abnormal chemosensory behavior | third instar larval stage, with shi^ts.UAS.cUa

(Hamid et al., 2021)

abnormal eclosion, with ChT^KK109385

(Hamid et al., 2019)

abnormal learning, with shi^1.UAS

(Pauls et al., 2010)

abnormal learning | third instar larval stage, with ChT^JF03028

(Hamid et al., 2021)

abnormal learning | third instar larval stage, with ChT^KK109385

(Hamid et al., 2021)

abnormal learning | third instar larval stage, with shi^ts.UAS.cUa

(Hamid et al., 2021)

abnormal locomotor behavior | larval stage, with ChT^KK109385

(Hamid et al., 2019)

abnormal memory | adult stage, with Dop2R^RNAi.UAS.cDa

(Scholz-Kornehl and Schwärzel, 2016)

abnormal memory | adult stage | heat sensitive, with shi^1.UAS

(Kirkhart and Scott, 2015, Xie et al., 2013, Zhang et al., 2013)

abnormal sleep, with Alk^GD42

(Bai and Sehgal, 2015)

increased mortality during development, with ChT^KK109385

(Hamid et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

The inhibition of γ class Kenyon cells by the expression of shi^ts.UAS.cUa under the control of Scer\GAL4^NP1131 at the restrictive temperature of 29[o]C leads to third instar foraging larvae showing increased naive chemotactic response as well as decreased olfactory habituation, to ethyl acetate.

(Hamid et al., 2021)

Inhibition (using shi^1.UAS at 32[o]C) of Scer\GAL4^NP1131 cells in adults significantly reduces 5 min (single-trial conditioned) and 30 min (multiple-trial conditioned) aversive taste memory, compared to controls; inhibition of a subset of Scer\GAL4^NP1131 cells (restricted using Scer\GAL80^Mef2.mb247) does not affect 5 min (single-trial conditioned) or 30 min (multiple-trial conditioned) aversive taste memory, compared to controls.

(Kirkhart and Scott, 2015)

Inhibition (using shi^1.UAS at 33[o]C) of Scer\GAL4^NP1131 cells in adults during testing significantly reduces 3 h aversive memory, compared to controls.

(Xie et al., 2013)

Inhibition (using shi^1.UAS at 31[o]C) of Scer\GAL4^NP1131 cells in adults significantly reduces short-term aversive olfactory, but not visual, unimodal memory, compared to controls; inhibition does not affect short-term aversive memory for tested olfactory cues that are associated with conditioned visual cues, compared to controls.

(Zhang et al., 2013)

External Data

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Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions