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General Information
Symbol
Dmel\Nf1c00617
Species
D. melanogaster
Name
FlyBase ID
FBal0160134
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
PBac{PB}Nf1c00617
Product class / Tool use(s)
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Nf1P2/Nf1c00617 male or female flies sleep significantly less than wild type.

Nf1c00617 males are smaller than control males, while females show no change.

Nf1c00617 flies exhibit 3 minute, 3 hour, and 24 hour memory deficits. In training trial assays, where flies are repeatedly trained with odor avoidance assays, Nf1P1 flies perform poorly even after one trial, but then exhibit wild-type levels of olfactory memory acquisition. When Nf1c00617 mutants and controls are both trained with three trials, immediate memory is identical (when performance is normalised to the control so memory decay can be compared). Likewise, memory tested at two subsequent time points is indistinguishable.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of Nf1Scer\UAS.cBa in mushroom body neurons during development and adulthood under the control of inducible Scer\GAL4Mef2.247.Switch (in a RU486 environment) completely rescues the 3 hour memory phenotype seen in Nf1c00617 mutants. Expression only during adulthood is sufficient for complete rescue.

Expression of Nf1Scer\UAS.cBa in α'/β' neurons under the control of Scer\GAL4c305a is not sufficient to rescue the 3 hour memory phenotype of Nf1c00617 homozygous mutants.

Expression of Nf1Scer\UAS.cBa in γ neurons under the control of Scer\GAL4NP1131 is not sufficient to rescue the 3 hour memory phenotype of Nf1c00617 homozygous mutants.

Expression of Nf1Scer\UAS.cBa throughout the central brain under the control of Scer\GAL4Mz1081 is sufficient to rescue the 3 hour memory phenotype found in Nf1c00617 mutants.

Expression of Nf1Scer\UAS.cBa throughout the central brain under the control of Scer\GAL4NP0009 is sufficient to rescue the 3 hour memory phenotype found in Nf1c00617 mutants.

Expression of Nf1Scer\UAS.cBa in the α/β mushroom body neurons under the control of Scer\GAL4c739 is sufficient to rescue the 3 hour memory phenotype found in Nf1c00617 mutants.

Expression of Nf1Scer\UAS.cBa in the central core of α/β mushroom body neurons under the control of Scer\GAL417d is not sufficient to rescue the 3 hour memory phenotype found in Nf1c00617 mutants.

The Nf1c00617 3 hour memory phenotype is fully rescued when Scer\GAL4c747 is used to express Nf1Scer\UAS.cBa. However, flies also carrying Scer\GAL80Mef2.PT exhibit a performance score that is indistinguishable from Nf1c00617 homozygous mutants.

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Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (4)