FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dop1R1UAS.cLa
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General Information
Symbol
Dmel\Dop1R1UAS.cLa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Liu
FlyBase ID
FBal0285851
Feature type
allele
Associated gene
Dmel\Dop1R1
Associated Insertion(s)
Carried in Construct
P{UAS-Dop1R1.L}
Also Known As
UAS-dDA1
Key Links
Transgenic product class
cDNA
(Liu et al., 2009)
wild_type
(Liu et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Liu et al., 2009)
wild_type
(Liu et al., 2009)
Mutagen
in vitro construct
(Liu et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-Dop1R1.L}
Cytology
Description

UAS drives expression of Dop1R1 cDNA.

(Liu et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Dop1R1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Dop1R1Scer\UAS.cLa under the control of Scer\GAL4elav-C155 has no effect on viability.

      (Cassar et al., 2015)

      Scer\GAL4c747-mediated expression of Dop1R1Scer\UAS.cLa results in significantly enhanced learning after aversive olfactory conditioning (flies trained to associate odors with an electric shock).

      (Liu et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      Dop1R1UAS.cLa, Scer\GAL4c747 has abnormal learning phenotype, non-enhanceable by RdlRNAi.4-5.UAS, Scer\GAL4c747

      (Liu et al., 2009)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Dop1R1Scer\UAS.cLa and RdldsRNA.4-5.Scer\UAS does not result in further enhancement of learning after aversive olfactory conditioning compared to expression of either single transgene.

      (Liu et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4Mef2.247/Dop1R1UAS.cLa rescues Dop1R1f02676

      (Ichinose et al., 2015)

      Dop1R1UAS.cLa/Scer\GAL4NP1131 rescues Dop1R1f02676

      (Lin et al., 2014)

      Scer\GAL4Tab2-201Y/Dop1R1UAS.cLa rescues Dop1R1f02676

      (Lin et al., 2014)
      Fails to rescue

      Dop1R1UAS.cLa/Scer\GAL4c305a fails to rescue Dop1R1f02676

      (Lin et al., 2014)

      Dop1R1UAS.cLa/Scer\GAL4c739 fails to rescue Dop1R1f02676

      (Lin et al., 2014)
      Comments

      Expression of Dop1R1Scer\UAS.cLa in mostly the γ (with Scer\GAL4NP1131 or Scer\GAL4Tab2-201Y), but not the αβ (Scer\GAL4c739) or α'β' (Scer\GAL4c305a) mushroom body neurons, produces a significant restoration of memory performance and learning in Dop1R1f02676 mutants. Despite Dop1R1f02676 flies exhibiting an apparent olfactory acuity defect, restoration of olfaction through expression of Dop1R1Scer\UAS.cLa with the Scer\GAL4c305a and Scer\GAL4c739 drivers, does not correlate with wild-type learning ability.

      (Lin et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Dop1R1Scer\UAS.cLa
      Dop1R1UAS.cLa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Liu
      Secondary FlyBase IDs
        References (6)