Expression of Dop2R^{dsRNA.Scer\UAS} RNAi under the control of Scer\GAL4^elav.PU results in decreased short-term memory (3 min) in an aversive olfactory memory assay compared to controls. Expression under the control of any of the following: Scer\GAL4^ple.PF, Scer\GAL4^NP1227, Scer\GAL4^GH298, Scer\GAL4^Sxl-NP2426, Scer\GAL4^GH146, Scer\GAL4^NP2631, Scer\GAL4^Mef2.247, Scer\GAL4^17d or Scer\GAL4^NP1131 results in a significant decrease in 3 hr olfactory memory in adult flies due decrease in its amnesia-resistant component. The RNAi expression controlled by Scer\GAL4^GH146 in combination with Scer\GAL80^ChAT.3.3P or by any of these drivers: Scer\GAL4^Orco.PU, Scer\GAL4^c320 or Scer\GAL4^c305a has no effect on the 3 hr memory or its components.

Flies expressing D2R^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Act5C.PI show decreased locomotor activity, both in young and old flies, compared to controls. Multiple indices of locomotor activity are decreased in the mutant flies, including "total activity counts", "amount of time active" and "number of activity-rest bouts".

Expression of D2R^{dsRNA.Scer\UAS} under the control of Scer\GAL4^elav-C155 does not result in decreased activity in 7 day-old flies, but activity levels are significantly reduced in 30 day-old flies.