FlyBase Allele Report: Dmel\CCKLR-17D1[KK108482]

General Information

Symbol

Dmel\CCKLR-17D1^KK108482

Species

D. melanogaster

Name

FlyBase ID

FBal0235597

Feature type

allele

Associated gene

Dmel\CCKLR-17D1

Associated Insertion(s)

Carried in Construct

P{KK108482}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108482}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108482

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurofibromatosis

modeled by Nf1^E2

(Walker et al., 2013)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | adult stage

(Mohammad et al., 2016)

lethal, with Scer\GAL4^Act5C.PU

(Kiss et al., 2013)

Phenotype Manifest In

Detailed Description

Statement

Reference

Pan-neuronal expression of CCKLR-17D1^KK108482 in adult flies (using 31[o]C heat-induced Scer\GAL4^nSyb.PS in combination with Scer\GAL80^ts.αTub84B) significantly decreases wall following behavior (posited measure of anxiety) in an arena, compared to non-induced (18[o]C) controls.

(Mohammad et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

CCKLR-17D1^KK108482/Scer\GAL4^Ras64B.PW is a suppressor of decreased body size | pupal stage phenotype of Nf1^E2

(Walker et al., 2013)

CCKLR-17D1^KK108482/Scer\GAL4^C23 is a suppressor of decreased body size | pupal stage phenotype of Nf1^E2

(Walker et al., 2013)

NOT Suppressor of

Statement

Reference

CCKLR-17D1^KK108482/Scer\GAL4^repo is a non-suppressor of decreased body size | pupal stage phenotype of Nf1^E2

(Walker et al., 2013)

Other

Statement

Reference

CCKLR-17D1^KK108482, CCKLR-17D3^GD3431, Scer\GAL4^Act5C.PU has lethal phenotype

(Kiss et al., 2013)

CCKLR-17D1^KK108482, CCKLR-17D3^GD3431, Scer\GAL4^elav.PLu has abnormal locomotor behavior phenotype

(Kiss et al., 2013)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Female flies expressing CCKLR-17D1^KK108482 and CCKLR-17D3^GD3431 under the control of Scer\GAL4^elav.PLu show reduced startle (air puff)-induced locomotor activity.

(Kiss et al., 2013)

Expression of CCKLR-17D1^KK108482 under the control of either Scer\GAL4^Ras64B.PW or Scer\GAL4^C23 suppresses the reduced pupal length phenotype seen in Nf1^E2 animals, while expression under the control of Scer\GAL4^repo has no significant effect.

(Walker et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v100760

P{KK108482}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

CCKLR-17D1^KK108482

(Mohammad et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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