Open Close
Reference
Citation
Melnikova, L., Elizar'ev, P., Erokhin, M., Molodina, V., Chetverina, D., Kostyuchenko, M., Georgiev, P., Golovnin, A. (2019). The same domain of Su(Hw) is required for enhancer blocking and direct promoter repression.  Sci. Rep. 9(1): 5314.
FlyBase ID
FBrf0241934
Publication Type
Research paper
Abstract

Suppressor of Hairy-wing Su(Hw) is a DNA-binding architectural protein that participates in the organization of insulators and repression of promoters in Drosophila. This protein contains acidic regions at both ends and a central cluster of 12 zinc finger domains, some of which are involved in the specific recognition of the binding site. One of the well-described in vivo function of Su(Hw) is the repression of transcription of neuronal genes in oocytes. Here, we have found that the same Su(Hw) C-terminal region (aa 720-892) is required for insulation as well as for promoter repression. The best characterized partners of Su(Hw), CP190 and Mod(mdg4)-67.2, are not involved in the repression of neuronal genes. Taken together, these results suggest that an unknown protein or protein complex binds to the C-terminal region of Su(Hw) and is responsible for the direct repression activity of Su(Hw).

PubMed ID
PubMed Central ID
PMC6441048 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Sci. Rep.
    Title
    Scientific reports
    ISBN/ISSN
    2045-2322
    Data From Reference