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General Information
Symbol
Scer\GAL4dsx-GAL4
Species
S. cerevisiae
Name
FlyBase ID
FBal0244775
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dsx-GAL4, dsxGAL4, dsxGAL4(1)
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Sequence encoding a GAL4 driver has been inserted immediately after the translational start codon of dsx in exon 2, which is common to male and female dsx mRNAs. This GAL4 coding sequence is terminated by a single stop codon. The two codons 3' of the GAL4 stop codon encode different amino acids than those normally found in dsx proteins, but otherwise the dsx sequences both 5' and 3' of the GAL4 insertion site are unaltered in the targeted chromosome. This allele is anticipated, barring internal re-initiation of translation, to be a null dsx allele.

Insertion components
TI{GAL4}dsxGAL4
Product class / Tool use(s)
Expression Data
Reporter Expression
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
cercus

Comment: pericuticular

male genitalia

Comment: pericuticular

Additional Information
Statement
Reference

Expression driven by Scer\GAL4dsx-GAL4 was restricted via a transgenic cell class-lineage intersection (CLIn) system to a subset of three clusters of sexually dimorphic neurons - PMP-e, pIP-e and a cluster in the superior medial protocerebrum - of specific Type II neuroblast lineages using Klac\KDRstg14. All but one (59-70) male and all 5 female adult fruitless pMP-e neurons are part of the DM4 lineage, the remaining male pMP-e neuron is part of the DM6 lineage, 27-34 male and 10-16 female pIP-e neurons are part of the DL2 lineage, and 3-5 male and 4 female neurons in the superior medial protocerebrum cluster are part of the DM2 lineage. In total, ~66% (~202/306) male and ~79% (~44/56) female Scer\GAL4dsx-GAL4 neurons intersect with Klac\KDRstg14.

A dsx GAL4 reporter is used to characterize the expression pattern of dsx at all stages of development, but particularly in larvae and adults. An extremely detailed description of the dsx expression pattern is presented with particular attention to whether the pattern is sexually dimorphic in the various tissues. Included is a detailed description of the expression pattern in the adult CNS and in adult peripheral sensory structures.

 
Marker for
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (15)