Open Close
General Information
Symbol
Dmel\y1
Species
D. melanogaster
Name
FlyBase ID
FBal0018607
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Comment:

A to C tranversion in the ATG translation initiation codon. The reference sequence strain, iso-1, carries the y1 mutation.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Known mutation in sequenced strain: single base change in start codon (see FBrf0051634).

Deletion of the y promoter, not enhancer.

A to C tranversion in the ATG translation initiation codon.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

y1 individuals have a 'yellow' body color; the sex combs show reduced melanization and the sex comb teeth appeared thinner and smoother than in controls; the aedeagus show no melanization defects.

y1 males show severely reduced mating success when paired with wild-type females: copulation initiation is reduced, but there are no significant changes in courtship behavior (courtship time or wing extension bouts) or courtship song (pulse frequency, sine frequency or inter pulse interval), as compared to controls. This defect is not observed when y1 females are paired with wild-type males or when y1 males are paired with y1 females.

y1/y1#8 females have a completely null y[-] pigmentation phenotype in the wings and in the body.

The presence of Dp(1;2)y2A increases pigmentation in both the body and wing cuticle in y1/y1#8 females.

y1 males have significantly reduced mating success compared to control males. The Dp(1;f)1187 minichromosome rescues the mating success of these mutants. y1 adults lack pigmentation throughout the body, the wings, bristles, aristae and tarsal claws. The sex combs of y1 males have a lighter colour than wild type.

Body colour: pigmentation score (where 1 = null/nearly null, 5 = wild type/nearly wild type): homozygote: 1 (wing), 1 (body), hemizygote: 1 (wing), 1 (body), y1/yeve-tata : 2 (wing), 2-3 (body), y1/yhsp70-tata : 4-5 (wing), 4+-5 (body), y1/yw-DPE26 : 4 (wing), 4 (body), y1/yw-DPE29 : 2 (wing), 1+-2 (body), y1/yeve-tata-1 : 1 (wing), 1 (body), y1/yhsp70-tata-1 : 1 (wing), 1 (body), y1/yw-DPE26-1 : 1 (wing), 1 (body), y1/yw-DPE29-1 : 1 (wing), 1 (body), y1/yP1\loxP.eve-700gin : 2+-3 (wing), 2+ (body), y1/yP1\loxP.hsp70-700gin : 5 (wing), 4+-5 (body), y1/yP1\loxP.w-700gin : 2+-3 (wing), 2+ (body).

Males have a reduced wing extension index (the percentage of each courtship ritual during which a male's wing is extended and vibrating) compared to wild type.

A stripe of dark pigment seen in wild-type adult females near the posterior edge of abdominal segments A2-A6. I y1 mutants the black melanin is lost from the stripes leaving a brown pigment. The cuticle anterior to the stripe has a tan appearance relative to wild-type. In the thorax and wings, wild-type flies have a uniform colour. In y1 mutants these structures become tan.

Homozygous y+s7 or y2s14 females have a stronger mutant phenotype than y+s7/y1 or y2s14/y1 females in the presence of ph-pP1.

The pigmentation induced in unpigmented y1 pharate adult tissue by incubation with dopamine in vitro closely resembles the y1 phenotype, producing brown pigmentation in all cuticle structures.

Body colour: no pigmentation.

Body colour: yellow; hairs & bristles brown with yellow tips; wing veins, wing hairs, yellow. Larval mouth part colour: yellow-brown. Larval denticle belt colour: yellow-brown.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
Other
Statement
Reference
Phenotype Manifest In
NOT suppressed by
Statement
Reference

y1 has phenotype, non-suppressible by su(Hw)2

Suppressor of
Statement
Reference

y1 is a suppressor of phenotype of svrpoi-Ca

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The glycerol hypersensitivity of flies expressing GykdsRNA.Scer\UAS under the control of Scer\GAL4c564 (seen as a reduction in survival on a glycerol only food source) is enhanced if the flies are also heterozygous for y1.

In a y1 hemizygous background, pigmentation in the thorax of Pk92BΔN.Scer\UAS.T:Zzzz\FLAG, Scer\GAL4pnr-MD237 flies is brown rather than black, particularly in the scutellum.

A stripe of dark pigment seen in wild-type adult females near the posterior edge of abdominal segments A2-A6. y1, e1 double mutants have brown pigment throughout the abdomen and the stripe is no longer distinct. In the thorax and wings, wild-type flies have a uniform colour. In y1 mutants these structures become tan. In e1 mutants the thorax and wings become more darkly pigmented, and new pigmentation patterns are seen. y1, e1 double mutants also show these patterns, but the black pigment is absent, and they consist of two shades of brown pigment.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Not rescued by
Comments

The expression of yUAS.cCa under the control of Scer\GAL4y.PG suppresses the yellow body color but not the male mating defects of y1 mutants.

The expression of yUAS.cCa under the control of Scer\GAL4dsx-GAL4 alone or under the combined control of Scer\GAL4dsx-GAL4 and Scer\GAL80nSyb.PS fully and partially rescues, respectively, the male mating defects of y1 mutants.

The expression of yUAS.cCa under the control of Scer\GAL4dsx.KI rescues both the body color and male mating defects of y1 mutants.

Flies carrying yΔ1A-2.w-hs.Scer\SceI.RS or yΔ1A-2.Δ1A-2'.w-hs.Scer\SceI.RS in a y1 background have dark pigmentation of all cuticle structures except the wing.

Images (1)
Stocks (49,282)
Notes on Origin
Discoverer

E.M. Wallace, Jan. 1911.

Comments
Comments

Marker mutation present in the strain used in the genome sequencing project.

y2 promoter causes trans-activation of enhancer.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (62)