FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

adult doublesex pC1 (female) neuron

ID (Ontology)

FBbt:00047349 (Fly Anatomy)

Definition

Doublesex-expressing neuron of the female that is part of a cluster in the posterior medial region of the protocerebrum. There are 5 of these cells per hemisphere and they are derived from the DM4 neuroblast (Ren et al., 2016). They are generally more active in virgin females than mated females (Wang et al., 2020). Subclasses can be distinguished by their characteristic branching patterns (Wang et al., 2020). They are cholinergic (Wang et al., 2020).[ FlyBase:FBrf0159058 FlyBase:FBrf0210397 FlyBase:FBrf0210735 FlyBase:FBrf0225543 FlyBase:FBrf0228365 FlyBase:FBrf0233706 FlyBase:FBrf0234085 FlyBase:FBrf0245074 ]

Also Known As

"doublesex-expressing posterior Cell-1 (female)" ; "dsx-expressing posterior Cell-1 (female)" ; "dsx-pC1 (female)"

Comment

Kimura et al. (2015) report around 27 pC1 (female) cells per hemisphere, Zhou et al. (2014) and Pavlou et al. (2016) report around 8, Ren et al. (2016) and Wang et al. (2020) report 5. Unlike in the male, there does not appear to be overlap between dsx pC1 and fru pMP-e in the female (Ren et al., 2016).

Links to External Ontologies

VFB:FBbt_00047349

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Alleles (FBal)	PHENOTYPE_MANIFEST_IN
Insertions (FBti)	EXPRESSION_STAGE_TISSUE_POSITION
Insertions (FBti)	PHENOTYPE_MANIFEST_IN
Constructs (FBtp)	PHENOTYPE_MANIFEST_IN

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Alleles	Split System Combinations	Insertions	Constructs
adult doublesex pC1 (female) neuron (all annotations which use CV term, excluding "NOT" statements)
adult doublesex pC1 (female) neuron \| adult stage		--	--
adult doublesex pC1 (female) neuron \| decreased number		--		--
adult doublesex pC1 (female) neuron \| increased number		--	--
adult doublesex pC1 (female) neuron \| P-stage		--	--

Spanning Tree (Parents/Children)

organism
 |__female organism_____________
cholinergic neuron              |
 |__adult cholinergic neuron____|
adult neuron                    |
 |__adult cholinergic neuron____|
adult DM4 lineage clone         |
 |__adult DM4 lineage neuron____|
sexually-dimorphic neuron       |
 |__adult doublesex pC1 neuron__|
CM4 lineage neuron              |
 |__adult DM4 lineage neuron____|
adult brain doublesex neuron    |
 |__adult doublesex pC1 neuron__|
adult CNS neuron                |
 |__adult DM4 lineage neuron____|
                                adult doublesex pC1 (female) neuron  50 rec.
                                 |__adult doublesex pC1a (female) neuron 6 rec.
                                 |__adult doublesex pC1b (female) neuron 3 rec.
                                 |__adult doublesex pC1c (female) neuron 6 rec.
                                 |__adult doublesex pC1d (female) neuron 11 rec.
                                 |__adult doublesex pC1e (female) neuron 15 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	adult DM4 lineage neuron adult doublesex pC1 neuron adult cholinergic neuron
Part of	female organism
Synonyms & Secondary IDs
Synonyms
	"doublesex-expressing posterior Cell-1 (female)" EXACT[ FlyBase:FBrf0159058 ] "dsx-expressing posterior Cell-1 (female)" EXACT[ FlyBase:FBrf0159058 ] "dsx-pC1 (female)" EXACT[ FlyBase:FBrf0159058 ]
Secondary IDs

External Crossreferences & Linkouts
	VFB:FBbt_00047349