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Citation
Rideout, E.J., Dornan, A.J., Neville, M.C., Eadie, S., Goodwin, S.F. (2010). Control of sexual differentiation and behavior by the doublesex gene in Drosophila melanogaster.  Nat. Neurosci. 13(4): 458--466.
FlyBase ID
FBrf0210397
Publication Type
Research paper
Abstract

Doublesex proteins, which are part of the structurally and functionally conserved Dmrt gene family, are important for sex determination throughout the animal kingdom. We inserted Gal4 into the doublesex (dsx) locus of Drosophila melanogaster, allowing us to visualize and manipulate cells expressing dsx in various tissues. In the nervous system, we detected differences between the sexes in dsx-positive neuronal numbers, axonal projections and synaptic density. We found that dsx was required for the development of male-specific neurons that coexpressed fruitless (fru), a regulator of male sexual behavior. We propose that dsx and fru act together to form the neuronal framework necessary for male sexual behavior. We found that disrupting dsx neuronal function had profound effects on male sexual behavior. Furthermore, our results suggest that dsx-positive neurons are involved in pre- to post-copulatory female reproductive behaviors.

PubMed ID
PubMed Central ID
PMC3092424 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

P{UAS-dsx.M} and P{UAS-dsx.F}.
Park and Burtis, 2013.3.21, P{UAS-dsx.M} and P{UAS-dsx.F}. [FBrf0221249]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Neurosci.
    Title
    Nature Neuroscience
    Publication Year
    1998-
    ISBN/ISSN
    1097-6256
    Data From Reference