FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Piezo
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General Information
Symbol
Dmel\Piezo
Species
D. melanogaster
Name
Piezo
Annotation Symbol
CG44122
Feature Type
protein_coding_gene
FlyBase ID
FBgn0264953
Gene Model Status
Current
Stock Availability
28 publicly available
Gene Summary
Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents (PubMed:22343891, PubMed:22343900). Plays a major role in nociception (response to strong or painful touch) (PubMed:22343891). Required for maintaining the mechanosensitivity of tarsal bristle mechanosensors (PubMed:32649914). During their evalulation of potential egg-laying sites, females determine the softest substrate for their eggs first by making a coarse evaluation of substrate hardness using mechanosensitive channels nan and Piezo in the leg tarsal bristles, followed by a much finer assessment using nan, iav and Tmc mechanosensitive channels on the labellum (PubMed:32649914). Acts in the nompC- and nan-expressing neurons of the female leg tarsals, to sense the mild differences in egg-laying substrate stiffness (PubMed:32649914). (UniProt, M9MSG8)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Dmpiezo

Key Links
Genomic Location
Cytogenetic map
28E9-28F1
Sequence location
Recombination map
2-30
RefSeq locus
NT_033779 REGION:8163073..8190137
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables mechanosensitive monoatomic ion channel activity
inferred from direct assay
(Coste et al., 2012)
inferred from mutant phenotype
(Zhang et al., 2020)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables mechanosensitive monoatomic cation channel activity
inferred from biological aspect of ancestor with PANTHER:PTN000323131
(GO Reference Genome Project, 2011-)
enables mechanosensitive monoatomic ion channel activity
inferred from electronic annotation with InterPro:IPR027272
(InterPro Project Members, 2004-)
Biological Process (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in cellular response to mechanical stimulus
inferred from mutant phenotype
(Coste et al., 2012, Kim et al., 2012)
involved_in detection of temperature stimulus involved in sensory perception of pain
inferred from mutant phenotype
(Liu et al., 2022)
involved_in mechanosensory behavior
inferred from mutant phenotype
(Kim et al., 2012)
involved_in monoatomic cation transmembrane transport
inferred from direct assay
(Coste et al., 2012)
involved_in monoatomic ion transmembrane transport
inferred from mutant phenotype
(Zhang et al., 2020)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in cellular response to mechanical stimulus
inferred from biological aspect of ancestor with PANTHER:PTN000323131
(GO Reference Genome Project, 2011-)
involved_in detection of mechanical stimulus
inferred from biological aspect of ancestor with PANTHER:PTN000323131
(GO Reference Genome Project, 2011-)
involved_in regulation of membrane potential
inferred from biological aspect of ancestor with PANTHER:PTN000323131
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in membrane
inferred from electronic annotation with InterPro:IPR027272
(InterPro Project Members, 2004-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000323194
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the PIEZO (TC 1.A.75) family. (M9MSG8)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
PIEZO ION CHANNELS -
Piezo proteins are an evolutionarily conserved ion channel family involved in mechanotransduction. (Adapted from FBrf0217754).
Protein Function (UniProtKB)
Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents (PubMed:22343891, PubMed:22343900). Plays a major role in nociception (response to strong or painful touch) (PubMed:22343891). Required for maintaining the mechanosensitivity of tarsal bristle mechanosensors (PubMed:32649914). During their evalulation of potential egg-laying sites, females determine the softest substrate for their eggs first by making a coarse evaluation of substrate hardness using mechanosensitive channels nan and Piezo in the leg tarsal bristles, followed by a much finer assessment using nan, iav and Tmc mechanosensitive channels on the labellum (PubMed:32649914). Acts in the nompC- and nan-expressing neurons of the female leg tarsals, to sense the mild differences in egg-laying substrate stiffness (PubMed:32649914).
(UniProt, M9MSG8)
Summary (Interactive Fly)

mechanically activated cation channel - stretch-activated mechanotransduction - mechanical nociceptor

Gene Model and Products
Number of Transcripts
11
Number of Unique Polypeptides
11

Please see the JBrowse view of Dmel\Piezo for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry M9MSG8)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Gene model reviewed during 6.03

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Piezo-RE
FBtr0335175
NM_164795
9714
2709
Piezo-RF
FBtr0335176
NM_001042881
9600
2671
Piezo-RG
FBtr0335177
NM_001169436
9645
2686
Piezo-RH
FBtr0335178
NM_001201789
9297
2570
Piezo-RI
FBtr0335179
NM_001201790
9240
2551
Piezo-RJ
FBtr0335180
NM_135344
9389
2621
Piezo-RK
FBtr0335181
NM_001273297
9300
2571
Piezo-RL
FBtr0335182
NM_001273298
9240
2551
Piezo-RM
FBtr0335183
NM_001273299
9186
2533
Piezo-RO
FBtr0347414
NM_001273300
10101
2838
Piezo-RP
FBtr0347415
NM_001316385
10506
2973
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Piezo-PE
FBpp0307168
306.9
2709
8.37
Q8IPG4
NP_723354
AAN11153
Piezo-PF
FBpp0307169
303.0
2671
8.64
Q0E8L0
NP_001036346
ABI31300
Piezo-PG
FBpp0307170
304.8
2686
8.23
E1JHB4
NP_001162907
ACZ94198
Piezo-PH
FBpp0307171
291.6
2570
8.54
M9MRE5
NP_001188718
ADV36968
Piezo-PI
FBpp0307172
289.4
2551
8.54
M9MSG8
NP_001188719
ADV36969
Piezo-PJ
FBpp0307173
297.3
2621
8.56
Q9VLS3
NP_609188
AAF52611
Piezo-PK
FBpp0307174
291.6
2571
8.96
M9PF50
NP_001260226
AGB92762
Piezo-PL
FBpp0307175
289.4
2551
8.44
M9PB69
NP_001260227
AGB92763
Piezo-PM
FBpp0307176
288.3
2533
8.38
M9PCC7
NP_001260228
AGB92764
Piezo-PO
FBpp0312564
319.9
2838
8.18
M9PCW8
NP_001260229
AGB92765
Piezo-PP
FBpp0312565
335.3
2973
7.85
A0A0S0WGQ9
NP_001303314
ALI30200
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Piezo using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.96

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
larval imaginal tissue | ubiquitous
(Grubbs et al., 2013)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
organism | gap expression pattern
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic Malpighian tubule
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
third instar larval stage
leg disc | restricted
(Grubbs et al., 2013)
antennal disc | restricted
(Grubbs et al., 2013)
eye disc | ubiquitous
(Grubbs et al., 2013)
wing disc | ubiquitous
(Grubbs et al., 2013)
Additional Descriptive Data

A ubiquitous basal expression pattern was observed throughout development by PCR methods. No transcripts were detected on Northern blots.

(Kurzik-Dumke et al., 1993)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Dorus et al., 2006)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Piezo in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 22 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Piezo
Transgenic constructs containing regulatory region of Piezo
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2L)Exel7034
(Kim et al., 2012, Ryder, 2004.4.26)
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal heat stress response | third instar larval stage, with Scer\GAL4ppk.1.9
abnormal neuroanatomy | larval stage | conditional
abnormal neuroanatomy | larval stage | recessive
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4ppk.1.9
abnormal neurophysiology
abnormal pain response | third instar larval stage
abnormal sensory perception, with Scer\GAL421-7
abnormal touch perception
abnormal touch response
abnormal touch response, with Scer\GAL4ppk.PG
abnormal touch response (with Df(2L)Exel7034)
abnormal wound healing | larval stage | recessive
increased rate of feeding behavior | adult stage | recessive
increased size | adult stage | recessive
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4Dll-md23
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
antenna, with Scer\GAL4Dll-md23
axon | larval stage
axon | larval stage | conditional
crop
dendrite | third instar larval stage, with Scer\GAL4ppk.1.9
larval dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4ppk.1.9
larval multidendritic class III neuron
larval multidendritic class I neuron | conditional
leg | ectopic, with Scer\GAL4Dll-md23
trichogen cell, with Scer\GAL4pnr-MD237
trichogen cell | increased number, with Scer\GAL4pnr-MD237
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\PIEZO1
12 of 14
Yes
Yes
 
3  
Hsap\PIEZO2
12 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (2)
Rnor\Piezo1
12 of 14
Yes
Yes
Rnor\Piezo2
12 of 14
Yes
Yes
Mus musculus (laboratory mouse) (2)
Mmus\Piezo2
12 of 14
Yes
Yes
Mmus\Piezo1
11 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (5)
Xtro\piezo1
9 of 13
Yes
Yes
Xtro\znf385a
8 of 13
No
Yes
Xtro\piezo2
7 of 13
No
Yes
Xtro\LOC100498074
6 of 13
No
Yes
Xtro\dhodh
1 of 13
No
No
Danio rerio (Zebrafish) (4)
Drer\piezo1
12 of 14
Yes
Yes
Drer\LOC100334952
11 of 14
No
Yes
Drer\LOC100534973
7 of 14
No
Yes
Drer\si:dkey-11f4.7
3 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\pezo-1
12 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP009276
11 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\AT2G48060
8 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Piezo. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (1)
Pzl
10 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    PiezoKO
    exacerbates  tauopathy
    modeled by Hsap\MAPTUAS.cWa
    (Feuillette et al., 2020)
    PiezoUAS.EGFP
    exacerbates  tauopathy
    modeled by Hsap\MAPTUAS.cWa
    (Feuillette et al., 2020)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PIEZO1; piezo type mechanosensitive ion channel component 1 (Er blood group)
    12 of 14
    611184
     
    PIEZO2; piezo type mechanosensitive ion channel component 2
    12 of 14
    613629
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Dmel gene
    Ortholog showing functional complementation
    Supporting References
    Piezo
    Hsap\PIEZO1
    (Wang et al., 2025)
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Piezo
    enhanceable
    ppk26
    (Guo et al., 2014)
    Piezo
    enhanceable
    ppk
    (Kim et al., 2012)
    Piezo
    suppressible
    TrpA1
    (Min et al., 2021)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    ppk26
    enhanceable
    Piezo
    (Guo et al., 2014)
    ppk
    enhanceable
    Piezo
    (Kim et al., 2012)
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-30
    Cytogenetic map
    28E9-28F1
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    28E9-28F1
    ; Limits computationally determined from genome sequence between P{lacW}l(2)k16919k16919&P{lacW}Bsgk09030 and P{lacW}Btk29Ak00206&P{EP}Btk29AEP715
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    2-30

    (FlyBase, 2016)

    2-27.0

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (28)
    Genomic Clones (20)
    cDNA Clones (40)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          PCR approach used to isolate 500bp Drosophila genomic sequence related to human c-fos. Southern blot data confirm this sequence present in Drosophila genome, but chromosome in situ hybridization failed to identify cytological region(s) containing this sequence.

          (Kurzik-Dumke et al., 1993)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: CG8486 anon- EST:Liang-1.32

          (FlyBase, 1996-)

          Source for merge of: OrfKD CG18103

          (Bayraktaroglu, 2000.4.12)

          Source for merge of: fos500 OrfKD

          (FlyBase, 1996-)

          Source for merge of: Piezo fos28F

          (FlyBase Genome Annotators, 2012)
          Additional comments

          Annotations CG8486 and CG18103 merged as CG44122 in release 5.47 of the genome annotation. Merge supported by RNA-seq junction data.

          (FlyBase Genome Annotators, 2012)

          Source for merge of CG8486 anon- EST:Liang-1.32 was sequence comparison ( date:030722 ).

          (FlyBase, 1996-)

          Source for merge of fos500 OrfKD was sequence comparison ( date:000817 ).

          (FlyBase, 1996-)
          Nomenclature History
          Source for database identify of

          Source for identity of: Piezo CG8486

          (Kim et al., 2012)
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (15)
          Reported As
          Symbol Synonym
          CG18103
          (Honjo et al., 2016, Keleman et al., 2009.8.5)
          CG31608
          CG44122
          (National Institute of Genetics Fly Stocks, 2022-, Meadows, 2014.12.12, FlyBase Genome Annotators, 2012)
          CG8486
          (Ashwal-Fluss et al., 2014, Christis and Munro, 2012, Jaspers et al., 2012, Kim et al., 2012, Rodriguez et al., 2012, Anholt and Williams, 2010, Kong et al., 2010, Keleman et al., 2009.8.5, Tan et al., 2009, Dorus et al., 2006)
          DmPIEZO
          (Moroni et al., 2018)
          DmPiezo
          (Hehlert et al., 2021, Khuong and Neely, 2013, Zhang et al., 2013, Coste et al., 2012)
          Dmpiezo
          (Liu and Zhang, 2022, Zhang et al., 2020, Ohyama et al., 2013, Kim et al., 2012)
          OrfKD
          Piezo
          (Yoshino et al., 2025, Eiman et al., 2024, Jeong, 2024, Kumar et al., 2024, Mahishi et al., 2024, Zhao et al., 2024, Khalili et al., 2023, Petsakou and Perrimon, 2023, Tian et al., 2023, Chopra et al., 2022, Gong et al., 2022, Marcogliese et al., 2022, National Institute of Genetics Fly Stocks, 2022-, Gowda et al., 2021, Kim et al., 2021, McLaughlin et al., 2021, Montell, 2021, Beqja et al., 2020, Crava et al., 2020, Feuillette et al., 2020, Fujisawa et al., 2020, Jiang et al., 2020, Wang et al., 2020, Chen and Read, 2019, Meltzer et al., 2019, Song et al., 2019, Zwick et al., 2019, He et al., 2018, Yan et al., 2018, Tokusumi et al., 2017, Transgenic RNAi Project members, 2017-, Gene Disruption Project members, 2016-, Honjo et al., 2016, Jeong et al., 2016, Gene Disruption Project members, 2015-, Gou et al., 2014, Grubbs et al., 2013)
          anon-EST:Liang-1.32
          clone 1.32
          (Liang and Biggin, 1998)
          fos28F
          fos500
          piezo
          (Guo et al., 2025, Qin et al., 2024, Petsakou et al., 2023, Yamanouchi et al., 2023, Li et al., 2022, Liu et al., 2022, Li and Montell, 2021, Guo et al., 2020, Zhang et al., 2020, Zhou et al., 2019, Zhang et al., 2016, Ramdya et al., 2015, Gorczyca et al., 2014, Guo et al., 2014)
          Name Synonyms
          DmPiezo
          (He et al., 2022)
          Dmpiezo
          (Kim et al., 2012)
          Piezo
          (Koehler and Huber, 2023, Zechini et al., 2022, Roy Choudhury et al., 2021)
          fos-related gene at 28F
          Secondary FlyBase IDs
          • FBgn0031993
          • FBgn0025998
          • FBgn0013442
          • FBgn0011820
          • FBgn0031994
          • FBgn0051608
          • FBgn0063629
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 79 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          References (152)