FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Pzl
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General Information
Symbol
Dmel\Pzl
Species
D. melanogaster
Name
Piezo-like
Annotation Symbol
CG45783
Feature Type
protein_coding_gene
FlyBase ID
FBgn0267430
Gene Model Status
Incomplete
Stock Availability
7 publicly available
Gene Summary
mechanically activated cation channel - stretch-activated mechanotransduction - mechanical nociceptor (Interactive Fly, Pzl )
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
81F3-81F4
Sequence location
Recombination map
3-47.1
RefSeq locus
NT_033777 REGION:2554162..3263582
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
Function
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables mechanosensitive monoatomic cation channel activity
inferred from biological aspect of ancestor with PANTHER:PTN000323131
(GO Reference Genome Project, 2011-)
enables mechanosensitive monoatomic ion channel activity
inferred from electronic annotation with InterPro:IPR027272
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with UniProtKB:M9MSG8
(Gene Ontology Curators, 2002-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in cellular response to mechanical stimulus
inferred from biological aspect of ancestor with PANTHER:PTN000323131
(GO Reference Genome Project, 2011-)
involved_in detection of mechanical stimulus
inferred from biological aspect of ancestor with PANTHER:PTN000323131
(GO Reference Genome Project, 2011-)
involved_in mechanosensory behavior
inferred from sequence or structural similarity with UniProtKB:M9MSG8
(Gene Ontology Curators, 2002-)
involved_in regulation of membrane potential
inferred from biological aspect of ancestor with PANTHER:PTN000323131
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in membrane
inferred from electronic annotation with InterPro:IPR027272
(InterPro Project Members, 2004-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000323194
(GO Reference Genome Project, 2011-)
located_in plasma membrane
inferred from sequence or structural similarity with UniProtKB:M9MSG8
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
PIEZO ION CHANNELS -
Piezo proteins are an evolutionarily conserved ion channel family involved in mechanotransduction. (Adapted from FBrf0217754).
Summary (Interactive Fly)

mechanically activated cation channel - stretch-activated mechanotransduction - mechanical nociceptor

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Pzl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A126GUQ2)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 6.02

Gene model incomplete due to gap in genomic sequence (terminal domain is truncated); polypeptide sequence represents the complete gene, based on analysis described in FBrf0228105.

Gene model reviewed during 6.04

Gene model reviewed during 6.06

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Pzl-RE
FBtr0445191
NM_001316564
6490
2326
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Pzl-PE
FBpp0401450
273.9
2326
9.66
A0A126GUQ2
NP_001303493
ALI30524
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pzl using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

3.61

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Pzl in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pzl
Transgenic constructs containing regulatory region of Pzl
Aberrations (Deficiencies and Duplications) ( 11 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\PIEZO1
11 of 14
Yes
No
 
3  
Hsap\PIEZO2
10 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (2)
Rnor\Piezo1
11 of 14
Yes
No
Rnor\Piezo2
9 of 14
No
No
Mus musculus (laboratory mouse) (2)
Mmus\Piezo1
10 of 14
Yes
No
Mmus\Piezo2
9 of 14
No
No
Xenopus tropicalis (Western clawed frog) (4)
Xtro\piezo1
9 of 13
Yes
Yes
Xtro\znf385a
8 of 13
No
Yes
Xtro\LOC100498074
6 of 13
No
Yes
Xtro\piezo2
6 of 13
No
No
Danio rerio (Zebrafish) (4)
Drer\piezo1
11 of 14
Yes
No
Drer\LOC100334952
10 of 14
No
No
Drer\LOC100534973
6 of 14
No
No
Drer\si:dkey-11f4.7
3 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\pezo-1
11 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP009276
8 of 12
Yes
No
Arabidopsis thaliana (thale-cress) (1)
Atha\AT2G48060
8 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Pzl. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (1)
Piezo
10 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PIEZO1; piezo type mechanosensitive ion channel component 1 (Er blood group)
    11 of 14
    611184
     
    PIEZO2; piezo type mechanosensitive ion channel component 2
    10 of 14
    613629
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Dmel gene
    Ortholog showing functional complementation
    Supporting References
    Pzl
    Hsap\PIEZO1
    (Hu et al., 2019)
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    Summary of Genetic Interactions
    Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-47.1
    Cytogenetic map
    81F3-81F4
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    81F3-81F4
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Heterochromatic, cytological location not yet determined.
    (FlyBase Genome Annotators, 2002-2003)
    Experimentally Determined Recombination Data
    Location

    3-47.1

    (FlyBase, 2016)

    3-44.1

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (7)
    Genomic Clones (174)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (1)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
            Other clones
              RNAi and Array Information
              Linkouts
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                  Other Comments

                  Sequence of transcript(s) changed in r6 genomic release relative to r5 release.

                  (FlyBase Genome Annotators, 2014)

                  Annotation CG41238 eliminated in release 5.18 of the genome annotation.

                  (FlyBase Genome Annotators, 2009)

                  New annotation (CG42617) in release 5.21 of the genome annotation.

                  (FlyBase Genome Annotators, 2009)

                  New annotation (CG41369) in release 5.2 of the genome annotation.

                  (Drosophila Heterochromatin Genome Project, 2007)

                  New annotation (CG41238) in release 5.2 of the genome annotation.

                  (Drosophila Heterochromatin Genome Project, 2007)

                  New annotation (CR41056) in release 5.2 of the genome annotation.

                  (Drosophila Heterochromatin Genome Project, 2007)

                  New annotation (CG40249) in release 3 of the genome annotation.

                  (FlyBase Genome Annotators, 2002-2003)

                  New annotation (CG40188) in release 3 of the genome annotation.

                  (FlyBase Genome Annotators, 2002-2003)

                  New annotation (CG40232) in release 3 of the genome annotation. New annotation (CG40328) in release 3 of the genome annotation.

                  (FlyBase Genome Annotators, 2002-2003)
                  Relationship to Other Genes
                  Source for database merge of

                  Source for merge of: CG41369 CG41238

                  (FlyBase Genome Annotators, 2009)

                  Source for merge of: CG41056 CR41056

                  (FlyBase Genome Annotators, 2009)

                  Source for merge of: CG40232 CG40328

                  (Drosophila Heterochromatin Genome Project, 2004)

                  Source for merge of: CG42617 CG40249 CG40188 CG42618 CG41056

                  (FlyBase Genome Annotators, 2014)
                  Additional comments

                  Annotations CG42617, CG40249, CG40188, CG42618 and CG41056 merged as CG45783 in release 6.02 of the genome annotation. This gene is no longer fragmented in the release 6 genome assembly.

                  (FlyBase Genome Annotators, 2014)

                  Annotations CG41369 and CG41238 merged as CG42618 in release 5.21 of the genome annotation.

                  (FlyBase Genome Annotators, 2009)

                  CG41056 and CR41056 merged as CG41056 in release 5.21 of the genome annotation.

                  (FlyBase Genome Annotators, 2009)

                  Annotations CG40232 and CG40328 merged as CG41056 in release 3.2 of the genome annotation.

                  (Drosophila Heterochromatin Genome Project, 2004)
                  Nomenclature History
                  Source for database identify of

                  Source for identity of: Pzl CG45783

                  (Hoskins et al., 2015)
                  Nomenclature comments
                  Etymology
                  Synonyms and Secondary IDs (15)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 36 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  DroID - A comprehensive database of gene and protein interactions.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  References (39)