FlyBase Allele Report: Scer\GAL4[iav.PP]

General Information

Symbol

Scer\GAL4^iav.PP

Species

S. cerevisiae

Name

inactive promoter construct of Petersen

FlyBase ID

FBal0263905

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

Carried in Construct

P{iav-GAL4.P}

PBac{iav-GAL4.P}

Also Known As

iav-GAL4

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Scholz et al., 2015, Petersen and Stowers, 2011)

Progenitor genotype

Carried in construct

P{iav-GAL4.P}

PBac{iav-GAL4.P}

Cytology

Description

GAL4 is expressed under the control of presumptive regulatory DNA from a location immediately upstream of the predicted translation start site of iav.

(Petersen and Stowers, 2011)

Allele components

Component

Use(s)

Regulatory region(s)

iav

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

abdominal vch1 neuron

(Petersen and Stowers, 2011)

abdominal vch2 neuron

(Petersen and Stowers, 2011)

abdominal lch1 neuron

(Petersen and Stowers, 2011)

larval abdominal lch5 neuron

(Petersen and Stowers, 2011)

Additional Information

Statement

Reference

ScerGAL4^iav.PP drives expression in larval chordotonal organ neurons.

(Petersen and Stowers, 2011)

Marker for

Reflects expression of

iav

(Petersen and Stowers, 2011)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

larval abdominal lch5 neuron, with Gαo^JF02844

(Bormann et al., 2025)

larval abdominal lch5 neuron | conditional, with Besp\bPAC^UAS.cSa

(Scholz et al., 2017)

larval head | conditional, with Crei\ChR2^{XXM.UAS.tdTomato}

(Scholz et al., 2017)

Detailed Description

Statement

Reference

Blocking Cho neurons' function by expressing Hsap\KCNJ2^UAS.EGFP under the control of Scer\GAL4^iav.PP induces abnormal locomotor behavior, with severely increased periods of head lifting and spontaneous backward movements compared to controls, as well as severely higher frequency of bending their bodies laterally to greater than 90[o], which is rarely observed in wild-type controls.

(Hu et al., 2019)

Optogenetic activation (using Zzzz\ChR^{2.XXM.UAS.tdTomato} with 440 nm (blue) light) of Scer\GAL4^iav.PP cells in larvae significantly increases the duration of head swinging, compared to controls.

Optogenetically increasing cAMP levels (using Besp\bPAC^UAS.cSa with 460-500 nm light) in Scer\GAL4^iav.PP cells in larvae reduces the response of lch5 neurons to mechanical stimulation, compared to controls.

(Scholz et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Gαo^UAS.cKa/Scer\GAL4^iav.PP is a suppressor of abnormal neurophysiology | larval stage phenotype of Cirl^KO.attP.w-

(Bormann et al., 2025)

Scer\GAL4^iav.PP/Hsap\PIEZO1^UAS.cJa is a suppressor of abnormal locomotor behavior | larval stage phenotype of Pzl^KO