FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PzlKO
Open Close
General Information
Symbol
Dmel\PzlKO
Species
D. melanogaster
Name
FlyBase ID
FBal0346229
Feature type
allele
Associated gene
Dmel\Pzl
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Hu et al., 2019)
Mutagen
CRISPR/Cas9
(Hu et al., 2019)
Progenitor genotype
Cytology
Description

Deletion of the N-terminal part of the Pzl gene, resulting in deletion of the sequence encoding the first 202 amino acid residues.

(Hu et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      PzlKO larvae exhibit an abnormal locomotor behavior, with severely increased periods of head lifting and spontaneous backward movements compared to controls, as well as severely higher frequency of bending their bodies laterally to greater than 90[o], which is rarely observed in wild-type controls; larvae show normal response sound, except at low-frequency (100Hz); larval Cho neurons show a significantly decreased response to body wall stimuli, as compared to controls. Adults do not show walking defects (speed or stride size) or climbing defects, as compared to controls.

      (Hu et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      PzlKO is rescued by Scer\GAL4iav.PP/PzlUAS.EGFP

      (Hu et al., 2019)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      PzlKO
      pzlKO
      (Hu et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)