FB2026_02 , released June 18, 2026
Allele: Dmel\PiezoNIG.8486R
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General Information
Symbol
Dmel\PiezoNIG.8486R
Species
D. melanogaster
Name
FlyBase ID
FBal0267721
Feature type
allele
Associated gene
Dmel\Piezo
Associated Insertion(s)
Carried in Construct
P{NIG.8486R}
Also Known As
UAS-piezo-RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Kim et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Kim et al., 2012)
Mutagen
in vitro construct
(Kim et al., 2012)
Progenitor genotype
Carried in construct
P{NIG.8486R}
Cytology
Description

UASt drives expression of an RNAi construct targeting Piezo.

(Kim et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-8486R
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Downregulation of Piezo in ppk neurons, through expression of PiezoNIG.8486R under the control of Scer\GAL4ppk.PG and Scer\GAL80ppk.1.0, blocks the attraction to acetic acid, seen when females flies are egg laying.

      Downregulation of Piezo, through expression of PiezoNIG.8486R under the control of Scer\GAL421-7, blocks the attraction to acetic acid, seen when females flies are egg laying.

      (Gou et al., 2014)

      Scer\GAL4ppk.PG-mediated expression of PiezoNIG.8486R results in larvae with a severe mechanical nociception response deficit.

      (Kim et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Enhancer of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Scer\GAL4ppk.PG-mediated co-expression of ppkKK104185 and PiezoNIG.8486R results in larvae with a more severe mechanical nociception response deficit (nearly complete abolishment of response) than expression of either ppkKK104185 or PiezoNIG.8486R alone. Co-expressing larvae are indistinguishable from wild type in assays for responses to high temperature or innocuous gentle touch.

      (Kim et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      PiezoNIG.8486R
      Name Synonyms
      Secondary FlyBase IDs
        References (6)