FB2026_02 , released June 18, 2026
Allele: Dmel\TrpA1UAS.(A).cKa
Open Close
General Information
Symbol
Dmel\TrpA1UAS.(A).cKa
Species
D. melanogaster
Name
FlyBase ID
FBal0285582
Feature type
allele
Associated gene
Dmel\TrpA1
Associated Insertion(s)
Carried in Construct
P{UAS-TrpA1(A).K}
Also Known As
UAS-TrpA1(A), UAS-TrpA1(A)10a
Key Links
Transgenic product class
wild_type
(Kang et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Kang et al., 2012)
Mutagen
in vitro construct
(Kang et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-TrpA1(A).K}
Cytology
Description

UAS regulatory sequences drive expression of a "TrpA1(A)" TrpA1 isoform containing the 10a alternative exon.

(Du et al., 2016)

UAS regulatory sequences drive expression of the "TRPA1(A)" isoform. Note that the isoform referred to as TRPA1(A) in FBrf0222493 is similar to that called "TRPA1-D" in FBrf0217493, except that "TRPA1(A)" has an additional N-terminal amino acids.

(Ni et al., 2013)

UAS regulatory sequences drive expression of the "TrpA1(A)" TrpA1 isoform.

(Kang et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
TrpA1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of TrpA1Scer\UAS.(A).cKa under the control of Scer\GAL4Gr5a.8.5 confers sensitivity to N-methylmaleimide in L-type labellar taste bristles (robust spiking is seen in a in an extracellular tip recording assay in response to 10mM N-methylmaleimide). The L-type taste bristles are not thermosensitive in these animals.

      (Kang et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of TrpA1Scer\UAS.(A).cKa in the arista under the control of Scer\GAL4Gr28b.d.PT does not rescue the "rapid negative thermotaxis" defects seen in Gr28bMB03888 mutant flies.

      (Ni et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      TrpA1UAS.(A).cKa/Scer\GAL4TrpA1.C-D partially rescues TrpA1ins

      (Du et al., 2016)
      Comments

      Expression of TrpA1Scer\UAS.(A).10b under the control of Scer\GAL4TrpA1.C-D is unable to rescue the uracil-dependent defecation defect, but is able to rescue the N-methylmaleimide-dependent defecation defect of TrpA1ins mutants.

      (Du et al., 2016)

      Expression of TrpA1Scer\UAS.(A).cKa under the control of Scer\GAL4Gr66a.PD restores an electrophysiological spiking response to N-methylmaleimide in berberine-sensitive i-type taste bristles in the labellum in TrpA1ins flies. Sensitivity to warming is not restored.

      Expression of TrpA1Scer\UAS.(A).cKa under the control of Scer\GAL4Gr66a.PD rescues avoidance of food containing N-methylmaleimide in TrpA1ins flies.

      (Kang et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      TrpA1A.Scer\UAS
      TrpA1Scer\UAS.(A).cKa
      TrpA1UAS.(A).cKa
      Name Synonyms
      Secondary FlyBase IDs
        References (8)