FB2022_03, released June 9, 2022

Gene: Dmel\Gr28b

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General Information
Symbol
Dmel\Gr28b
Species
D. melanogaster
Name
Gustatory receptor 28b
Annotation Symbol
CG13788
Feature Type
protein_coding_gene
FlyBase ID
FBgn0045495
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Atypical expression suggests also nongustatory roles in the nervous system and tissues involved in proprioception, hygroreception, and other sensory modalities. It is also possible that it has chemosensory roles in the detection of internal ligands. (UniProt, Q9VM08)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Gr28b.a, Gr28b.d, Gr28b.e, Gr28bD, Gr28bA

Key Links
Genomic Location
Cytogenetic map
28A1-28A1
Sequence location
Recombination map
2-27
RefSeq locus
NT_033779 REGION:7454826..7462247
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables taste receptor activity
inferred from sequence or structural similarity
(Clyne et al., 2000)
non-traceable author statement
(assigned by UniProt )
(Dunipace et al., 2001)
Biological Process (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in defense response to bacterium
inferred from mutant phenotype
(Ayres et al., 2008)
involved_in feeding behavior
inferred from mutant phenotype
(Ayres and Schneider, 2009)
involved_in immune response
inferred from mutant phenotype
(Ayres and Schneider, 2009)
involved_in melanization defense response
inferred from mutant phenotype
(Ayres and Schneider, 2009)
involved_in negative phototaxis
inferred from mutant phenotype
(Xiang et al., 2010)
involved_in phototransduction
inferred from direct assay
(Xiang et al., 2010)
involved_in thermosensory behavior
inferred from mutant phenotype
(Ni et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in sensory perception of taste
inferred from electronic annotation with InterPro:IPR013604
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
inferred from sequence or structural similarity
(Clyne et al., 2000)
non-traceable author statement
(assigned by UniProt )
(Dunipace et al., 2001)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
is_active_in axon
inferred from biological aspect of ancestor with PANTHER:PTN000475107
(assigned by GO_Central )
(Gaudet et al., 2011)
is_active_in dendrite
inferred from biological aspect of ancestor with PANTHER:PTN000475107
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in integral component of membrane
inferred from electronic annotation with InterPro:IPR013604
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
non-traceable author statement
(assigned by UniProt )
(Dunipace et al., 2001)
is_active_in neuronal cell body
inferred from biological aspect of ancestor with PANTHER:PTN000475107
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr66a subfamily. (Q9VM08)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
GUSTATORY RECEPTORS -
The Gustatory receptors are a divergent group of (non-GPCR) seven-transmembrane chemoreceptors that are expressed in gustatory sensilla receptor neurons. They detect tastants (non-volatile compounds) via contact chemosensation. (Adapted from FBrf0208984).
Protein Function (UniProtKB)
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Atypical expression suggests also nongustatory roles in the nervous system and tissues involved in proprioception, hygroreception, and other sensory modalities. It is also possible that it has chemosensory roles in the detection of internal ligands.
(UniProt, Q9VM08)
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\Gr28b for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VM08)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model based on FBrf0141780.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Gr28b-RA
FBtr0079458
NM_139357
1541
452
Gr28b-RB
FBtr0079459
NM_205921
1585
443
Gr28b-RC
FBtr0079460
NM_205920
1595
470
Gr28b-RD
FBtr0079461
NM_205919
1505
440
Gr28b-RE
FBtr0079462
NM_205918
1526
447
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Gr28b-PA
FBpp0079086
51.6
452
9.36
NP_647614
AAF52520
Gr28b-PB
FBpp0089144
50.5
443
9.59
Q059D1
NP_995643
AAS64648
Gr28b-PC
FBpp0089145
53.6
470
9.28
Q9VM08
NP_995642
AAS64649
Gr28b-PD
FBpp0089142
50.5
440
9.08
NP_995641
AAS64650
Gr28b-PE
FBpp0089143
50.4
447
9.58
NP_995640
AAS64651
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gr28b using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:
 low
high 
Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.
Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:
 low
high 
as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
gustatory receptor neuron of labellum
(Scott et al., 2001)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
antenna

Comment: arista and antenna tissue were assayed together

(Ni et al., 2013)
arista

Comment: arista and antenna tissue were assayed together

(Ni et al., 2013)
Additional Descriptive Data

Gr28b detection via RT-PCR does not differentiate between isoforms Gr28b-RA, Gr28b-RB, Gr28b-RC and Gr28b-RD. Isoform Gr28b-RE was not detected in arista and antenna.

(Ni et al., 2013)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{Gr22e-GAL4.D}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
tibia | restricted
(Dunipace et al., 2001)
gustatory receptor neuron of tarsal segment | subset
(Dunipace et al., 2001)
gnathal ganglion | restricted
(Dunipace et al., 2001)
gustatory receptor neuron of tibia | subset
(Dunipace et al., 2001)
labellar taste bristle | subset
(Dunipace et al., 2001)
third segment of antenna | restricted
(Dunipace et al., 2001)
gustatory receptor neuron | subset
(Miyamoto and Amrein, 2008, Bray and Amrein, 2003, Dunipace et al., 2001)
wing margin bristle | subset
(Dunipace et al., 2001)
gustatory receptor neuron of wing margin bristle | subset
(Dunipace et al., 2001)
olfactory receptor neuron of maxillary palpus | subset
(Dunipace et al., 2001)
olfactory receptor neuron of third segment of antenna | subset
(Dunipace et al., 2001)
ventral cibarial sense organ neuron of proximal sensillum | subset
(Dunipace et al., 2001)
dorsal cibarial sense organ neuron | subset
(Dunipace et al., 2001)
maxillary palpus | restricted
(Dunipace et al., 2001)
gustatory receptor neuron of labellar taste bristle | subset
(Thorne and Amrein, 2008, Dunipace et al., 2001)
tarsal segment | restricted
(Dunipace et al., 2001)
olfactory receptor neuron | subset
(Dunipace et al., 2001)
labral sense organ neuron | subset
(Dunipace et al., 2001)
chemosensory neuron of labellum
(Thorne et al., 2004)
chemosensory neuron of adult labral sense organ
(Thorne et al., 2004)
chemosensory neuron of ventral cibarial sense organ
(Thorne et al., 2004)
chemosensory neuron of mesothoracic leg
(Thorne et al., 2004)
chemosensory neuron of metathoracic leg
(Thorne et al., 2004)
chemosensory neuron of prothoracic leg
(Thorne et al., 2004)
gustatory receptor neuron of proboscis
(Wang et al., 2004)
gustatory receptor neuron of labellum
(Wang et al., 2004)
intermediate labellar taste bristle I-b | faint
(Hiroi et al., 2002)
bitter-sensitive labellar taste bristle
(Hiroi et al., 2002)
short labellar taste bristle S-c | faint
(Hiroi et al., 2002)
short labellar taste bristle
(Hiroi et al., 2002)
short labellar taste bristle S-a
(Hiroi et al., 2002)
short labellar taste bristle S-b
(Hiroi et al., 2002)
gustatory receptor neuron of short labellar taste bristle | subset
(Thorne and Amrein, 2008)
gustatory receptor neuron of intermediate labellar taste bristle | subset
(Thorne and Amrein, 2008)
prothoracic leg taste bristle chemosensory neuron | subset
(Miyamoto and Amrein, 2008)
Reporter: P{Gr28b.a-GAL4.3}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
gustatory receptor neuron of terminal organ
(Kwon et al., 2011)
gustatory receptor neuron of the epiphysis
(Kwon et al., 2011)
larval gnathal ganglion
(Kwon et al., 2011)
larval gustatory receptor neuron of the epiphysis DP1
(Choi et al., 2016)
adult stage
high salt/bitter-sensing neuron | subset of prothoracic tarsal segment 5
(Ling et al., 2014)
gustatory receptor neuron | subset of short labellar taste bristle | subset
(Weiss et al., 2011)
gustatory receptor neuron | subset of intermediate labellar taste bristle | subset
(Weiss et al., 2011)
high salt/bitter-sensing neuron of adult labellum sensillum
(Weiss et al., 2011)
intermediate labellar taste bristle I-a

Comment: isoform Gr28b-RA

(Weiss et al., 2011, Weiss et al., 2011)
intermediate labellar taste bristle

Comment: isoform Gr28b-RA

(Weiss et al., 2011, Weiss et al., 2011)
intermediate labellar taste bristle I-b

Comment: isoform Gr28b-RA

(Weiss et al., 2011, Weiss et al., 2011)
short labellar taste bristle S-b

Comment: isoform Gr28b-RA

(Weiss et al., 2011, Weiss et al., 2011)
short labellar taste bristle S-a | intense

Comment: isoform Gr28b-RA

(Weiss et al., 2011)
short labellar taste bristle S-a

Comment: isoform Gr28b-RA

(Weiss et al., 2011, Weiss et al., 2011)
Reporter: P{Gr28b.a-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
terminal organ | restricted
(Thorne and Amrein, 2008)
third instar larval stage
gustatory receptor neuron of terminal organ | subset
(Mishra et al., 2018)
larval ventral nerve cord | restricted
(Mishra et al., 2018)
embryonic/larval brain | restricted
(Mishra et al., 2018)
embryonic/larval proventriculus | restricted
(Mishra et al., 2018)
embryonic/larval midgut | restricted
(Mishra et al., 2018)
adult stage
gustatory receptor neuron | subset
(Thorne and Amrein, 2008)
gustatory receptor neuron of labellar taste bristle | subset
(Thorne and Amrein, 2008)
gustatory receptor neuron | subset of ventral cibarial sense organ
(Thorne and Amrein, 2008)
gustatory receptor neuron | faint | subset of prothoracic tarsal segment 5
(Thorne and Amrein, 2008)
gnathal ganglion | restricted
(Thorne and Amrein, 2008)
Reporter: P{Gr28b.b-GAL4.4.7}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult abdominal multidendritic neuron | subset
(Park and Kwon, 2011)
adult stage | male
male-specific neuron | subset
(Park and Kwon, 2011)
adult stage | female
female-specific neuron | subset
(Park and Kwon, 2011)
Reporter: P{Gr28b.b-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- larval stage
embryonic/larval oenocyte | faint
(Thorne and Amrein, 2008)
third instar larval stage
larval ventral nerve cord | restricted
(Mishra et al., 2018)
embryonic/larval brain | restricted
(Mishra et al., 2018)
multidendritic neuron | subset
(Mishra et al., 2018)
embryonic/larval midgut | restricted
(Mishra et al., 2018)
adult stage
gustatory receptor neuron | subset
(Thorne and Amrein, 2008)
gustatory receptor neuron of short labellar taste bristle | subset
(Thorne and Amrein, 2008)
maxillary palpus | restricted
(Thorne and Amrein, 2008)
campaniform sensillum | subset of wing vein L3
(Thorne and Amrein, 2008)
campaniform sensillum | subset of wing vein L1
(Thorne and Amrein, 2008)
dendritic arborizing neuron | subset of abdomen | dorsal
(Thorne and Amrein, 2008)
gnathal ganglion | restricted
(Thorne and Amrein, 2008)
multidendritic neuron
(Thorne and Amrein, 2008)
adult oenocyte
(Thorne and Amrein, 2008)
adult antennal lobe | restricted
(Thorne and Amrein, 2008)
Reporter: P{Gr28b.c-GAL4.6.5}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
larval abdominal ventral multidendritic neuron v'td2
(Qian et al., 2018)
adult stage
high salt/bitter-sensing neuron | subset of prothoracic tarsal segment 5
(Ling et al., 2014)
high salt/bitter-sensing neuron | subset of mesothoracic tarsal segment 5
(Ling et al., 2014)
high salt/bitter-sensing neuron | subset of metathoracic tarsal segment 5
(Ling et al., 2014)
adult abdominal multidendritic neuron | subset
(Park and Kwon, 2011)
adult stage | male
male-specific neuron | subset
(Park and Kwon, 2011)
adult stage | female
female-specific neuron | subset
(Park and Kwon, 2011)
Reporter: P{Gr28b.c-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval oenocyte | faint
(Thorne and Amrein, 2008)
larval stage
terminal organ | restricted
(Thorne and Amrein, 2008)
third instar larval stage
larval ventral nerve cord | restricted
(Mishra et al., 2018)
multidendritic neuron | subset
(Mishra et al., 2018)
embryonic/larval midgut | restricted
(Mishra et al., 2018)
adult stage
gustatory receptor neuron | subset
(Thorne and Amrein, 2008)
gustatory receptor neuron of labellar taste bristle | subset
(Thorne and Amrein, 2008)
gustatory receptor neuron of short labellar taste bristle | subset
(Thorne and Amrein, 2008)
gustatory receptor neuron of intermediate labellar taste bristle | subset
(Thorne and Amrein, 2008)
gustatory receptor neuron | subset of labral sense organ neuron
(Thorne and Amrein, 2008)
gustatory receptor neuron | subset of adult labral sense organ
(Thorne and Amrein, 2008)
gustatory receptor neuron | subset of ventral cibarial sense organ
(Thorne and Amrein, 2008)
gustatory receptor neuron | subset of dorsal cibarial sense organ
(Thorne and Amrein, 2008)
gustatory receptor neuron | faint | subset of prothoracic tarsal segment 5
(Thorne and Amrein, 2008)
neuron | faint | subset of prothoracic tarsal segment 5
(Thorne and Amrein, 2008)
maxillary palpus | restricted
(Thorne and Amrein, 2008)
Johnston organ neuron | subset
(Thorne and Amrein, 2008)
campaniform sensillum | subset of wing vein L3
(Thorne and Amrein, 2008)
campaniform sensillum | subset of wing vein L1
(Thorne and Amrein, 2008)
mechanosensory neuron | subset of leg
(Thorne and Amrein, 2008)
prothoracic femoral chordotonal organ
(Thorne and Amrein, 2008)
metathoracic femoral chordotonal organ
(Thorne and Amrein, 2008)
mesothoracic femoral chordotonal organ
(Thorne and Amrein, 2008)
dendritic arborizing neuron | subset of abdomen | dorsal
(Thorne and Amrein, 2008)
gnathal ganglion | restricted
(Thorne and Amrein, 2008)
multidendritic neuron
(Thorne and Amrein, 2008)
adult antennal lobe | restricted
(Thorne and Amrein, 2008)
bitter-sensitive labellar taste bristle
(Sang et al., 2019)
short labellar taste bristle S-c
(Sang et al., 2019)
short labellar taste bristle
(Sang et al., 2019)
short labellar taste bristle S-a
(Sang et al., 2019)
short labellar taste bristle S-b
(Sang et al., 2019)
intermediate labellar taste bristle
(Sang et al., 2019)
intermediate labellar taste bristle I-b
(Sang et al., 2019)
Reporter: P{Gr28b.d-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
gustatory receptor neuron of the hypophysis
(Mishra et al., 2018)
gustatory receptor neuron of the epiphysis
(Mishra et al., 2018)
embryonic/larval brain | restricted
(Mishra et al., 2018)
larval ventral nerve cord | restricted
(Mishra et al., 2018)
adult stage
high salt/bitter-sensing neuron | subset of prothoracic tarsal segment 5
(Ling et al., 2014)
gustatory receptor neuron | subset
(Thorne and Amrein, 2008)
gustatory receptor neuron of labellar taste bristle | subset
(Thorne and Amrein, 2008)
gustatory receptor neuron | subset of ventral cibarial sense organ
(Thorne and Amrein, 2008)
gustatory receptor neuron | faint | subset of prothoracic tarsal segment 5
(Thorne and Amrein, 2008)
neuron | faint | subset of prothoracic tarsal segment 5
(Thorne and Amrein, 2008)
neuron | subset of arista
(Thorne and Amrein, 2008)
campaniform sensillum | subset of wing vein L3
(Thorne and Amrein, 2008)
campaniform sensillum | subset of wing vein L1
(Thorne and Amrein, 2008)
mechanosensory neuron | subset of leg
(Thorne and Amrein, 2008)
prothoracic femoral chordotonal organ
(Thorne and Amrein, 2008)
metathoracic femoral chordotonal organ
(Thorne and Amrein, 2008)
mesothoracic femoral chordotonal organ
(Thorne and Amrein, 2008)
dendritic arborizing neuron | subset of abdomen | dorsal
(Thorne and Amrein, 2008)
aristal sensory neuron VP2
(Liu et al., 2015, Ni et al., 2013)
neuron | subset of wing vein L3
(Ni et al., 2013)
neuron | subset of femur
(Ni et al., 2013)
neuron | subset of tarsal segment
(Ni et al., 2013)
neuron | subset of proboscis
(Ni et al., 2013)
gustatory receptor neuron | subset of short labellar taste bristle | subset
(Weiss et al., 2011)
high salt/bitter-sensing neuron of adult labellum sensillum
(Weiss et al., 2011)
short labellar taste bristle S-b

Comment: isoform Gr28b-RD

(Weiss et al., 2011, Weiss et al., 2011)
adult antennal lobe glomerulus
(Thorne and Amrein, 2008)
adult abdominal multidendritic neuron | subset
(Park and Kwon, 2011)
Reporter: P{Gr28b.d-lexA.L}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
aristal sensory neuron VP2
(Liu et al., 2015)
Reporter: P{Gr28b.e-GAL4.4.245}
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
terminal organ
(Scott et al., 2001)
embryonic/larval gut | restricted
(Scott et al., 2001)
embryonic/larval mouth | restricted
(Scott et al., 2001)
terminal organ | restricted
(Thorne and Amrein, 2008)
third instar larval stage
gustatory receptor neuron of terminal organ
(Kwon et al., 2011)
larval gnathal ganglion
(Kwon et al., 2011)
gustatory receptor neuron of terminal organ | subset
(Mishra et al., 2018)
embryonic/larval brain | restricted
(Mishra et al., 2018)
larval ventral nerve cord | restricted
(Mishra et al., 2018)
embryonic/larval proventriculus | restricted
(Mishra et al., 2018)
embryonic/larval midgut | restricted
(Mishra et al., 2018)
adult stage
high salt/bitter-sensing neuron | subset of prothoracic tarsal segment 5
(Ling et al., 2014)
chemosensory neuron of labellum
(Thorne et al., 2004)
chemosensory neuron of ventral cibarial sense organ
(Thorne et al., 2004)
chemosensory neuron of prothoracic leg
(Thorne et al., 2004)
labellum
(Scott et al., 2001)
cibarial sense organ
(Scott et al., 2001)
gustatory receptor neuron | subset
(Thorne and Amrein, 2008)
gustatory receptor neuron of labellar taste bristle | subset
(Thorne and Amrein, 2008)
gustatory receptor neuron | subset of ventral cibarial sense organ
(Thorne and Amrein, 2008)
gustatory receptor neuron | faint | subset of prothoracic tarsal segment 5
(Thorne and Amrein, 2008)
gnathal ganglion | restricted
(Thorne and Amrein, 2008)
gustatory receptor neuron | subset of short labellar taste bristle | subset
(Weiss et al., 2011)
gustatory receptor neuron | subset of intermediate labellar taste bristle | subset
(Weiss et al., 2011)
high salt/bitter-sensing neuron of adult labellum sensillum
(Weiss et al., 2011)
intermediate labellar taste bristle

Comment: isoform Gr28b-RE

(Weiss et al., 2011, Weiss et al., 2011)
intermediate labellar taste bristle I-b

Comment: isoform Gr28b-RE

(Weiss et al., 2011, Weiss et al., 2011)
short labellar taste bristle S-b

Comment: isoform Gr28b-RE

(Weiss et al., 2011, Weiss et al., 2011)
short labellar taste bristle S-a | intense

Comment: isoform Gr28b-RE

(Weiss et al., 2011)
intermediate labellar taste bristle I-b | intense

Comment: isoform Gr28b-RE

(Weiss et al., 2011)
short labellar taste bristle S-a

Comment: isoform Gr28b-RE

(Weiss et al., 2011)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Gr28b in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Gr28b
Transgenic constructs containing regulatory region of Gr28b
Aberrations (Deficiencies and Duplications) ( 2 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal feeding behavior
abnormal immune response | conditional
abnormal neurophysiology, with Scer\GAL4Gr89a.2
abnormal neurophysiology, with Scer\GAL4Mhc.PW
abnormal neurophysiology, with Scer\GAL4VGlut-OK371
abnormal neurophysiology | adult stage
abnormal neurophysiology | adult stage | drug conditional
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
abnormal pain response | larval stage
abnormal sensory perception
abnormal sensory perception, with Scer\GAL4ppk.1.9
abnormal sensory perception (with Df(2L)Exel7031)
abnormal temperature response
abnormal temperature response, with Scer\GAL4Act5C.PU
abnormal temperature response (with Df(2L)Exel7031)
long lived
Phenotype manifest in
Allele
adult antennal lobe projection neuron VP5+VP2 l2PN
adult antennal lobe projection neuron VP5+VP2 l2PN | drug conditional
adult multiglomerular antennal lobe projection neuron VP4+VP2+VL1 l2PN | drug conditional
intermediate labellar taste bristle, with Scer\GAL4Gr89a.2
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (0)
No records found.
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (0)
No records found.
Rattus norvegicus (Norway rat) (0)
No records found.
Xenopus tropicalis (Western clawed frog) (0)
No records found.
Danio rerio (Zebrafish) (0)
No records found.
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\lite-1
2 of 15
Yes
No
Cele\egl-47
1 of 15
No
Yes
Cele\gur-3
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (47)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Gr28a
3 of 10
Gr66a
3 of 10
Gr2a
2 of 10
Gr22c
2 of 10
Gr22e
2 of 10
Gr32a
2 of 10
Gr39a
2 of 10
Gr43a
2 of 10
Gr68a
2 of 10
Gr94a
2 of 10
Gr98b
2 of 10
Gr8a
1 of 10
Gr9a
1 of 10
Gr10a
1 of 10
Gr10b
1 of 10
Gr21a
1 of 10
Gr22a
1 of 10
Gr22b
1 of 10
Gr22d
1 of 10
Gr22f
1 of 10
Gr23a
1 of 10
Gr33a
1 of 10
Gr36a
1 of 10
Gr36b
1 of 10
Gr36c
1 of 10
Gr39b
1 of 10
Gr47b
1 of 10
Gr57a
1 of 10
Gr58a
1 of 10
Gr58b
1 of 10
Gr59a
1 of 10
Gr59b
1 of 10
Gr59c
1 of 10
Gr59d
1 of 10
Gr59e
1 of 10
Gr59f
1 of 10
Gr63a
1 of 10
Gr77a
1 of 10
Gr92a
1 of 10
Gr93a
1 of 10
Gr93b
1 of 10
Gr93c
1 of 10
Gr93d
1 of 10
Gr97a
1 of 10
Gr98a
1 of 10
Gr98c
1 of 10
Gr98d
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Gr28b
    enhanceable
    TrpA1
    (Xiang et al., 2010)
    Gr28b
    suppressible
    TrpA1
    (Ni et al., 2013)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    TrpA1
    suppressible
    Gr28b
    (Ni et al., 2013)
    TrpA1
    enhanceable
    Gr28b
    (Xiang et al., 2010)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-27
    Cytogenetic map
    28A1-28A1
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    28A1-28A1
    Limits computationally determined from genome sequence between P{PZ}cuc10607 and P{EP}EP2419EP2419&P{EP}EP575
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    2-27

    (FlyBase, 2016)

    2-24.3

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (7)
    Genomic Clones (20)
    cDNA Clones (4)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of
      Additional comments
      Other Comments

      Gr28b is essential for class IV dendritic arborization neuron light responses.

      (Xiang et al., 2010)
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 45 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      Other crossreferences
      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL - MARRVEL (model organism gene)
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      MIST (genetic) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (27)
      Reported As
      Symbol Synonym
      28A3
      (Smith, 2001)
      CG13788
      (Meadows, 2017.1.11, Keleman et al., 2009.8.5, Perkins et al., 2009, Ayres et al., 2008, Robertson, 2003.6.22, Dunipace et al., 2001)
      GR28B
      (Ni et al., 2013)
      GR28B(D)
      (Li and Gong, 2017)
      GR28b
      (Montell, 2021, Montell, 2013, Montell, 2009)
      GRLU.2
      Gr28A3
      (Millburn, 2001.4.25, Scott and Axel, 2001.4.25, Scott et al., 2001)
      Gr28A4
      (Scott and Axel, 2001.4.25)
      Gr28b
      (George and Stanewsky, 2021, Gowda et al., 2021, McLaughlin et al., 2021, Guo et al., 2020, Sato and Yamamoto, 2020, Wolf et al., 2020, Zhou et al., 2020, Budelli et al., 2019, Hall et al., 2019, He et al., 2019, Rimal and Lee, 2019, Rimal et al., 2019, Sang et al., 2019, Lopez et al., 2018, Mishra et al., 2018, Lamaze et al., 2017, Luo et al., 2017, Poudel et al., 2017, Sung et al., 2017, Crocker et al., 2016, Duun Rohde et al., 2016, Zhan et al., 2016, Barbagallo and Garrity, 2015, Green et al., 2015, Guntur et al., 2015, Shim et al., 2015, Liman et al., 2014, Mauthner et al., 2014, Menuz et al., 2014, Fan et al., 2013, Ni et al., 2013, Short and Lazzaro, 2013, Yamanaka et al., 2013, Xiang et al., 2010, Robertson, 2009, Zhou et al., 2009, Thorne and Amrein, 2008, Turner et al., 2008)
      Gr28b(D)
      (Xiao and Xu, 2021)
      Gr28b.a
      (Chen and Dahanukar, 2020, Mishra et al., 2018, Delventhal and Carlson, 2016, French et al., 2015, Weiss et al., 2011, Weiss et al., 2011, Thorne and Amrein, 2008, Robertson, 2001.11.11)
      Gr28b.b
      (Mishra et al., 2018, Thorne and Amrein, 2008, Robertson, 2001.11.11)
      Gr28b.c
      (Mishra et al., 2018, Thorne and Amrein, 2008, Robertson, 2001.11.11)
      Gr28b.d
      (Mishra et al., 2018, French et al., 2015, Weiss et al., 2011, Weiss et al., 2011, Thorne and Amrein, 2008, Robertson, 2001.11.11)
      Gr28b.e
      (Mishra et al., 2018, Weiss et al., 2011, Weiss et al., 2011, Thorne and Amrein, 2008, Robertson, 2001.11.11)
      Gr28bA
      (Mishra et al., 2018, Inomata et al., 2008, McBride et al., 2007, Amrein and Thorne, 2005)
      Gr28bB
      (Mishra et al., 2018, McBride et al., 2007, Amrein and Thorne, 2005)
      Gr28bC
      (Mishra et al., 2018, McBride et al., 2007, Amrein and Thorne, 2005)
      Gr28bD
      (Mishra et al., 2018, Inomata et al., 2008, McBride et al., 2007, Amrein and Thorne, 2005)
      Gr28bE
      (Mishra et al., 2018, McBride et al., 2007, Amrein and Thorne, 2005)
      Gr28be
      (Colomb and Stocker, 2007, Colomb et al., 2007, Thorne et al., 2005, Thorne et al., 2004)
      GrLU2
      (Scott and Axel, 2001.4.25)
      LU.2
      (Clyne et al., 2000)
      gr28b
      (Riveron et al., 2013, Chambers et al., 2012, Ayres and Schneider, 2009, Ayres et al., 2008)
      Name Synonyms
      Gustatory receptor 28A4
      (Scott and Axel, 2001.4.25)
      Gustatory receptor 28b
      (Robertson, 2001.11.11)
      Gustatory receptor LU.2
      (Clyne et al., 2000)
      Secondary FlyBase IDs
      • FBgn0031917
      • FBgn0041218
      • FBgn0045496
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      Study result (0)
      Result
      Result Type
      Title
      References (116)