FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Gr2a
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General Information
Symbol
Dmel\Gr2a
Species
D. melanogaster
Name
Gustatory receptor 2a
Annotation Symbol
CG18531
Feature Type
protein_coding_gene
FlyBase ID
FBgn0265139
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its not yet determined substrates. (UniProt, Q9W594)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Gr2B1, EG:BACN32G11.1

Key Links
Genomic Location
Cytogenetic map
2A3-2A4
Sequence location
Recombination map
1-0.2
RefSeq locus
NC_004354 REGION:1452430..1454177
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables G protein-coupled receptor activity
inferred from sequence or structural similarity
(Clyne et al., 2000)
enables ligand-gated monoatomic ion channel activity
inferred from sequence or structural similarity with UniProtKB:Q9V4K2
(Gene Ontology Curators, 2002-)
enables taste receptor activity
non-traceable author statement
(Dunipace et al., 2001)
inferred from sequence or structural similarity
(Clyne et al., 2000)
non-traceable author statement
(Clyne et al., 2000)
Biological Process (5 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in chemosensory behavior
inferred from biological aspect of ancestor with PANTHER:PTN001080220
(GO Reference Genome Project, 2011-)
involved_in detection of chemical stimulus involved in sensory perception of taste
non-traceable author statement
(Dunipace et al., 2001, Clyne et al., 2000)
involved_in male courtship behavior
inferred from biological aspect of ancestor with PANTHER:PTN001080220
(GO Reference Genome Project, 2011-)
involved_in monoatomic ion transmembrane transport
inferred from sequence or structural similarity with UniProtKB:Q9V4K2
(Gene Ontology Curators, 2002-)
involved_in sensory perception of taste
inferred from electronic annotation with InterPro:IPR013604
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity
(Clyne et al., 2000)
non-traceable author statement
(Clyne et al., 2000)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
is_active_in axon
inferred from biological aspect of ancestor with PANTHER:PTN000475107
(GO Reference Genome Project, 2011-)
is_active_in dendrite
inferred from biological aspect of ancestor with PANTHER:PTN000475107
(GO Reference Genome Project, 2011-)
located_in membrane
inferred from electronic annotation with InterPro:IPR013604
(InterPro Project Members, 2004-)
non-traceable author statement
(Dunipace et al., 2001, Clyne et al., 2000)
is_active_in neuronal cell body
inferred from biological aspect of ancestor with PANTHER:PTN000475107
(GO Reference Genome Project, 2011-)
is_active_in plasma membrane
inferred from sequence or structural similarity with UniProtKB:Q9V4K2
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily. (Q9W594)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
GUSTATORY RECEPTORS -
The Gustatory receptors are a divergent group of (non-GPCR) seven-transmembrane chemoreceptors that are expressed in gustatory sensilla receptor neurons. They detect tastants (non-volatile compounds) via contact chemosensation. (Adapted from FBrf0208984).
Protein Function (UniProtKB)
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its not yet determined substrates.
(UniProt, Q9W594)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Gr2a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9W594)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.39

According to FBrf0141780, Initiator methione is 4 residues upstream of published sequence Q9W594.

The upstream initiator methionine described in FBrf0141780 is not conserved in any but the most closely related species.

Gene model reviewed during 5.49

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Gr2a-RB
FBtr0114515
NM_080299
1508
410
Gr2a-RC
FBtr0300224
NM_001169162
1562
428
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Gr2a-PB
FBpp0113007
46.5
410
7.25
D4G7C5
NP_525038
AAF45624
Gr2a-PC
FBpp0289461
48.5
428
7.48
Q9W594
NP_001162633
ACZ95170
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gr2a using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.33

Transcript Expression
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
adult abdomen
(Vernier et al., 2023)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Gr2a in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Gr2a
Transgenic constructs containing regulatory region of Gr2a
Aberrations (Deficiencies and Duplications) ( 1 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal neurophysiology, with Scer\GAL4Gr89a.2
Phenotype manifest in
Allele
intermediate labellar taste bristle, with Scer\GAL4Gr89a.2
short labellar taste bristle, with Scer\GAL4Gr89a.2
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (0)
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (0)
Mus musculus (laboratory mouse) (0)
Xenopus tropicalis (Western clawed frog) (0)
Danio rerio (Zebrafish) (0)
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\lite-1
2 of 14
Yes
Yes
Cele\egl-47
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (17)
Agam\GPRGR4
4 of 12
Yes
Yes
Agam\GPRGR3
3 of 12
No
Yes
Agam\GPRGR7
3 of 12
No
Yes
Agam\GPRGR6
2 of 12
No
Yes
Agam\GPRGR33
2 of 12
No
No
Agam\GPRGR34
2 of 12
No
No
Agam\GPRGR2
1 of 12
No
No
Agam\GPRGR12
1 of 12
No
Yes
Agam\GPRGR26
1 of 12
No
No
Agam\GPRGR27
1 of 12
No
No
Agam\GPRGR35
1 of 12
No
No
Agam\GPRGR37
1 of 12
No
Yes
Agam\GPRGR43
1 of 12
No
No
Agam\GPRGR45
1 of 12
No
No
Agam\GPRGR46
1 of 12
No
No
Agam\GPRGR47
1 of 12
No
Yes
Agam\GPRGR53
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Gr2a. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (45)
Gr28a
4 of 13
Gr28b
4 of 13
Gr32a
3 of 13
Gr66a
3 of 13
Gr68a
3 of 13
Gr98b
3 of 13
Gr8a
2 of 13
Gr22c
2 of 13
Gr22e
2 of 13
Gr23a
2 of 13
Gr33a
2 of 13
Gr39a
2 of 13
Gr39b
2 of 13
Gr43a
2 of 13
Gr98a
2 of 13
Gr98c
2 of 13
Gr9a
1 of 13
Gr10a
1 of 13
Gr21a
1 of 13
Gr22a
1 of 13
Gr22b
1 of 13
Gr22d
1 of 13
Gr22f
1 of 13
Gr36a
1 of 13
Gr36b
1 of 13
Gr36c
1 of 13
Gr57a
1 of 13
Gr58a
1 of 13
Gr58b
1 of 13
Gr59a
1 of 13
Gr59b
1 of 13
Gr59c
1 of 13
Gr59d
1 of 13
Gr59e
1 of 13
Gr59f
1 of 13
Gr63a
1 of 13
Gr77a
1 of 13
Gr89a
1 of 13
Gr92a
1 of 13
Gr93a
1 of 13
Gr93b
1 of 13
Gr93c
1 of 13
Gr93d
1 of 13
Gr94a
1 of 13
Gr98d
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    Summary of Genetic Interactions
    Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-0.2
    Cytogenetic map
    2A3-2A4
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    2A3-2A4
    Limits computationally determined from genome sequence between P{EP}futschEP1419 and P{EP}brEP1515
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    1-0.2

    (FlyBase, 2016)

    1-0.1

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (7)
    Genomic Clones (12)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (3)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: EG:BACN32G11.1 CG18531

            (Bayraktaroglu, 2000.4.12)

            Source for merge of: Gr2a GR1F.1

            (FlyBase, 1996-)
            Additional comments

            FBrf0126794 states that 'GR1F.1' is associated with accession number AL035632, range 7301– 8711. BLASTing that particular region of AL035632 hits the 'CG14786' gene (which is not a Gr); but BLASTing the whole AL035632 sequence does give a hsp hit with e=0 to 'Gr2a'. 'Gr2a' is computationally mapped to band 2A, which is adjacent to 1F. Finally, the 2 sequence records attached to the GR1F.1 record (AX058701 & CAC22535) map specifically to 'Gr2a'.

            (FlyBase, 1996-)
            Nomenclature History
            Source for database identify of
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (11)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 29 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            MIST (protein-protein) - An integrated Molecular Interaction Database
            References (60)