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General Information
Symbol
Scer\GAL4NPFR.6.6
Species
S. cerevisiae
Name
FlyBase ID
FBal0152217
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
npfr1-gal4, npfr-gal4
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

A 6.6kb fragment containing NPFR upstream sequence and the first exon regulates expression of a GAL4 driver.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Expression Data
Reporter Expression
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Information
Statement
Reference

Expression is observed in neuropeptide F receptor-positive neurons.

 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Acute thermogenetic activation (using TrpA1Scer\UAS.cUa at 29[o]C) of Scer\GAL4NPFR.6.6 neurons results in a significant decrease of sleep amount (especially during the 12hr dark phases), compared to controls. This short-sleep phenotype progressively declines with prolonged activation, particularly during the light phase.

Inhibition of neural activity in Scer\GAL4NPFR.6.6-expressing neurons does not affect sensitivity to (S,Z,Z)-CH503 (a more potent stereoisomer of the gustatory sex pheromone CH503). As in wild type flies, courtship defects are seen in response to (S,Z,Z)-CH503.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Scer\GAL4NPFR.6.6
Scer\GAL4NPFR1.6.6
Name Synonyms
Secondary FlyBase IDs
    References (11)