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Citation
Wu, Q., Wen, T., Lee, G., Park, J.H., Cai, H.N., Shen, P. (2003). Developmental control of foraging and social behavior by the Drosophila neuropeptide Y-like system.  Neuron 39(1): 147--161.
FlyBase ID
FBrf0161062
Publication Type
Research paper
Abstract

Animals display stereotyped behavioral modifications during development, but little is known about how genes and neural circuits are regulated to turn on/off behaviors. Here we report that Drosophila neuropeptide F (dNPF), a human NPY homolog, coordinates larval behavioral changes during development. The brain expression of npf is high in larvae attracted to food, whereas its downregulation coincides with the onset of behaviors of older larvae, including food aversion, hypermobility, and cooperative burrowing. Loss of dNPF signaling in young transgenic larvae led to the premature display of behavioral phenotypes associated with older larvae. Conversely, dNPF overexpression in older larvae prolonged feeding, and suppressed hypermobility and cooperative burrowing behaviors. The dNPF system provides a new paradigm for studying the central control of cooperative behavior.

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Related Publication(s)
Note

NPY and the regulation of behavioral development.
Sokolowski, 2003, Neuron 39(1): 6--8 [FBrf0160965]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference