FlyBase Gene Report: Cbeta\DT

FB2026_02 , released June 18, 2026

FB2026_02 , released June 18, 2026

Gene: Cbeta\DT

General Information

Symbol

Cbeta\DT

Species

L. Corynephage beta

Name

Diphtheria toxin gene

Annotation Symbol

Feature Type

engineered_foreign_gene

FlyBase ID

FBgn0014443

Gene Model Status

Stock Availability

1 publicly available

Gene Summary

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All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

Cbβ\DT-A, diphtheria toxin

Foreign Gene Data

Foreign sequence; species == Corynephage beta; gene == 'DT, Diphtheria toxin gene'; UniProt/Swiss- Prot:P00588 .

(FlyBase Curators, 1992-)

Summaries

Alleles, Insertions, Transgenic Constructs

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 15 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cbeta\DT

Transgenic constructs containing regulatory region of Cbeta\DT

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^ER54

Cbeta\DT^A-I.UAS

lethal, with Scer\GAL4^ER115

Cbeta\DT^A-I.UAS

lethal, with Scer\GAL4^ER156

Cbeta\DT^A-I.UAS

lethal, with Scer\GAL4^ER168

Cbeta\DT^A-I.UAS

lethal, with Scer\GAL4^ER212

Cbeta\DT^A-I.UAS

lethal, with Scer\GAL4^ER.tsl

Cbeta\DT^A-I.UAS

lethal | RU486 conditional, with Scer\GAL4^Switch1.106

Cbeta\DT^A-I.UAS

lethal | RU486 conditional, with Scer\GAL4^Switch2.30

Cbeta\DT^A-I.UAS

lethal - all die before end of pupal stage, with Scer\GAL4^NP1017

Cbeta\DT^A-I.UAS

viable, with Scer\GAL4^DJ651

Cbeta\DT^A-I.UAS

viable, with Scer\GAL4^DJ656

Cbeta\DT^A-I.UAS

viable, with Scer\GAL4^EDTP-DJ694

Cbeta\DT^A-I.UAS

viable, with Scer\GAL4^Lk6-DJ634

Cbeta\DT^A-I.UAS

viable, with Scer\GAL4^Switch1.106

Cbeta\DT^A-I.UAS

viable, with Scer\GAL4^Switch2.30

Cbeta\DT^A-I.UAS

Sterility

Allele

female sterile | RU486 conditional, with Scer\GAL4^Switch1.106

Cbeta\DT^A-I.UAS

male semi-sterile

Other Phenotypes

Allele

abnormal behavior | adult stage, with Scer\GAL4^NPF.1

Cbeta\DT^A-I.UAS

abnormal behavior | adult stage | male, with Scer\GAL4^Gr32a.3.776

Cbeta\DT^A-I.UAS

abnormal behavior | adult stage | male, with Scer\GAL4^Gr32a.3.776, Scer\GAL80^{tsh-md621-GAL80}

Cbeta\DT^A-I.UAS

abnormal behavior | larval stage, with Scer\GAL4^NPF.1

Cbeta\DT^A-I.UAS

abnormal behavior | larval stage, with Scer\GAL4^NPFR.6.6

Cbeta\DT^A-I.UAS

abnormal courtship behavior, with Scer\GAL4^NPF.1

Cbeta\DT^A-I.UAS

abnormal courtship behavior | male, with Scer\GAL4^Gr32a.3.776

Cbeta\DT^A-I.UAS

abnormal courtship behavior | male, with Scer\GAL4^Gr32a.3.776, Scer\GAL80^{tsh-md621-GAL80}

Cbeta\DT^A-I.UAS

abnormal developmental rate, with Scer\GAL4^NPF.1

Cbeta\DT^A-I.UAS

abnormal feeding behavior | larval stage, with Scer\GAL4^NPF.1

Cbeta\DT^A-I.UAS

abnormal feeding behavior | larval stage, with Scer\GAL4^NPFR.6.6

Cbeta\DT^A-I.UAS

abnormal neuroanatomy, with Scer\GAL4^GH146

Cbeta\DT^A-I.UAS

abnormal neuroanatomy, with Scer\GAL4^Mz19

Cbeta\DT^A-I.UAS

abnormal neuroanatomy, with Scer\GAL4^Mz19, Scer\GAL4^Or88a.PW

Cbeta\DT^A-I.UAS

abnormal neuroanatomy, with Scer\GAL4^Or47b.7.467

Cbeta\DT^A-I.UAS

abnormal neuroanatomy, with Scer\GAL4^Or88a.PW

Cbeta\DT^A-I.UAS

abnormal neuroanatomy, with Scer\GAL4^{Orco.2.642.Hsim\VP22}

Cbeta\DT^A-I.UAS

abnormal neuroanatomy | adult stage, with Scer\GAL4^0670-G4

Cbeta\DT^A-I.UAS

abnormal neuroanatomy | adult stage, with Scer\GAL4^NP3056

Cbeta\DT^A-I.UAS

abnormal neuroanatomy | larval stage, with Scer\GAL4^GMR82E12

Cbeta\DT^A-I.UAS

abnormal neurophysiology

Cbeta\DT^A-I.Pdf

abnormal neurophysiology | adult stage, with Scer\GAL4^Gr5a.8.5

Cbeta\DT^A-I.UAS

abnormal neurophysiology | adult stage, with Scer\GAL4^Gr64f.9.7

Cbeta\DT^A-I.UAS

abnormal neurophysiology | adult stage, with Scer\GAL4^Ir56b.PK

Cbeta\DT^A-I.UAS

abnormal neurophysiology | somatic clone, with Scer\GAL4^NP1017

Cbeta\DT^A-I.UAS

abnormal smell perception, with Scer\GAL4^Or1a.PF

Cbeta\DT^A-I.UAS

abnormal smell perception, with Scer\GAL4^Or42a.PF

Cbeta\DT^A-I.UAS

abnormal smell perception, with Scer\GAL4^Or49a.PF

Cbeta\DT^A-I.UAS

abnormal smell perception, with Scer\GAL4^{Orco.2.642.Hsim\VP22}

Cbeta\DT^A-I.UAS

abnormal taste perception, with Scer\GAL4^Gr5a.8.5

Cbeta\DT^A-I.UAS

abnormal taste perception, with Scer\GAL4^Gr66a.3.153

Cbeta\DT^A-I.UAS

abnormal taste perception | somatic clone, with Scer\GAL4^NP1017

Cbeta\DT^A-I.UAS

abnormal visual behavior, with Scer\GAL4^P2.4.Pdf

Cbeta\DT^A-I.UAS

chemical resistant, with Scer\GAL4^NPF.1

Cbeta\DT^A-I.UAS

chemical resistant, with Scer\GAL4^NPFR.6.6

Cbeta\DT^A-I.UAS

increased cell death, with Scer\GAL4^Or1a.PF

Cbeta\DT^A-I.UAS

increased cell death, with Scer\GAL4^Or42a.PF

Cbeta\DT^A-I.UAS

increased cell death, with Scer\GAL4^Or49a.PF

Cbeta\DT^A-I.UAS

increased cell death, with Scer\GAL4^{Orco.2.642.Hsim\VP22}

Cbeta\DT^A-I.UAS

some die during pupal stage, with Scer\GAL4^NP1017

Cbeta\DT^A-I.UAS

Cbeta\DT^A.ninaE

visible | cold sensitive

Phenotype manifest in

Allele

adult antennal lobe, with Scer\GAL4^0670-G4

Cbeta\DT^A-I.UAS

adult antennal lobe, with Scer\GAL4^NP3056

Cbeta\DT^A-I.UAS

adult antennal lobe projection neuron VA1d adPN, with Scer\GAL4^{Orco.2.642.Hsim\VP22}

Cbeta\DT^A-I.UAS

adult brain, with Scer\GAL4^NPF.1

Cbeta\DT^A-I.UAS

adult fat body | RU486 conditional, with Scer\GAL4^Switch1.106

Cbeta\DT^A-I.UAS

adult fat body | RU486 conditional, with Scer\GAL4^Switch2.30

Cbeta\DT^A-I.UAS

antennal lobe glomerulus VA1, with Scer\GAL4^Mz19, Scer\GAL4^Or88a.PW

Cbeta\DT^A-I.UAS

antennal lobe glomerulus VA1, with Scer\GAL4^Or88a.PW

Cbeta\DT^A-I.UAS

axon terminus | larval stage, with Scer\GAL4^GMR82E12

Cbeta\DT^A-I.UAS

border follicle cell, with Scer\GAL4^ER.tsl

Cbeta\DT^A-I.UAS

dMP2 neuron, with Scer\GAL4^ftz.ng

Cbeta\DT^A.UAS

egg, with Scer\GAL4^ER.tsl

Cbeta\DT^A-I.UAS

embryonic/larval olfactory receptor neuron, with Scer\GAL4^{Orco.2.642.Hsim\VP22}

Cbeta\DT^A-I.UAS

eye photoreceptor cell

Cbeta\DT^Y28stop.chp

fan-shaped body, with Scer\GAL4^NPF.1

Cbeta\DT^A-I.UAS

gustatory neuron & labellum | somatic clone, with Scer\GAL4^NP1017

Cbeta\DT^A-I.UAS

labellar taste bristle | somatic clone, with Scer\GAL4^NP1017

Cbeta\DT^A-I.UAS

large labellar taste bristle, with Scer\GAL4^Gr5a.8.5

Cbeta\DT^A-I.UAS

large labellar taste bristle, with Scer\GAL4^Gr64f.9.7

Cbeta\DT^A-I.UAS

large labellar taste bristle, with Scer\GAL4^Ir56b.PK

Cbeta\DT^A-I.UAS

larval DA1 motor neuron, with Scer\GAL4^ftz.ng

Cbeta\DT^A.UAS

larval MP1 neuron, with Scer\GAL4^ftz.ng

Cbeta\DT^A.UAS

larval nociceptive neuropil, with Scer\GAL4^GMR82E12

Cbeta\DT^A-I.UAS

male accessory gland

Cbeta\DT^A.Acp95EF

male accessory gland main cell

Cbeta\DT^A.Acp95EF

micropyle, with Scer\GAL4^ER.tsl

Cbeta\DT^A-I.UAS

neuron & antennal glomerulus, with Scer\GAL4^GH146

Cbeta\DT^A-I.UAS

neuron & antennal glomerulus, with Scer\GAL4^Mz19

Cbeta\DT^A-I.UAS

neuron & antennal glomerulus VA1, with Scer\GAL4^Mz19, Scer\GAL4^Or88a.PW

Cbeta\DT^A-I.UAS

olfactory neuron & antennal glomerulus VA1, with Scer\GAL4^Mz19, Scer\GAL4^Or88a.PW

Cbeta\DT^A-I.UAS

olfactory neuron & antennal glomerulus VA1, with Scer\GAL4^Or47b.7.467

Cbeta\DT^A-I.UAS

olfactory neuron & antennal glomerulus VA1, with Scer\GAL4^Or88a.PW

Cbeta\DT^A-I.UAS

ommatidium | cold sensitive

oocyte, with Scer\GAL4^ER168

Cbeta\DT^A-I.UAS

pCC neuron, with Scer\GAL4^ftz.ng

Cbeta\DT^A.UAS

photoreceptor cell R1

Cbeta\DT^A.ninaE

photoreceptor cell R2

Cbeta\DT^A.ninaE

photoreceptor cell R3

Cbeta\DT^A.ninaE

photoreceptor cell R4

Cbeta\DT^A.ninaE

photoreceptor cell R5

Cbeta\DT^A.ninaE

photoreceptor cell R6

Cbeta\DT^A.ninaE

Cbeta\DT^A.ninaE

polar follicle cell, with Scer\GAL4^ER.tsl

Cbeta\DT^A-I.UAS

posterior aeropyle, with Scer\GAL4^ER.tsl

Cbeta\DT^A-I.UAS

Cbeta\DT^Y28stop.chp

Cbeta\DT^A.ninaE

Cbeta\DT^A.ninaE

Cbeta\DT^A.ninaE

Cbeta\DT^A.ninaE

Cbeta\DT^A.ninaE

Cbeta\DT^A.ninaE

Cbeta\DT^A.Acp95EF

vMP2 neuron, with Scer\GAL4^ftz.ng

Cbeta\DT^A.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Class of Gene

engineered_foreign_gene

Stocks and Reagents

Stocks (1)

25039

w^*; P{UAS-Cbeta\DT.I}18/CyO

Other Comments

tud males produce seminal fluid but no spermatozoa, transgenic Cbβ\DT-A males produce no detectable spermatozoa and no detectable main-cell products in the seminal fluid. Lifespan of females mated to Cbβ\DT-A males is greater than those mated to tud males (FBrf0079936). The entire cost of mating is attributable to receiving male main-cell products, the main cell products have a quantitative effect (FBrf0079936).

(Keller, 1995)

A method that uses Cbβ\DT-A, the Scer\FLP1 recognition target sequences and the Scer\GAL4-Scer\UAS activation system can be used to ablate specific neurons in the embryo and to examine the consequences.

(Lin et al., 1995)

Accessory gland function has been determined by diphtheria toxin directed cell ablation. Only accessory gland secretions are essential for the short-term inhibition to remating. Long term inhibition to remating depends only on the storage of sperm in the female.

(Kalb et al., 1993)

Temperature sensitive Cbβ\DT-A mutants are expressed in Drosophila and temperature dependence of the mutant toxin is assayed.

(Bellen et al., 1992)

Toxin-mediated ablation is used to study aspects of the visual system development.

(Kunes and Steller, 1991)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

Cbeta\DT

Cbeta\DT-A

Cbβ\DT-A

(Stevens, 2008.5.22)

DT

(Fox and Spradling, 2009)

Dt

(Kashio and Miura, 2020)

Name Synonyms

Diphtheria toxin gene

Diphtheria toxin gene subunit A

diphtheria toxin

(Howlader et al., 2006, Keene et al., 2004)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 0 )

References (95)