FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Scer\GAL4Gr66a.3.153
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General Information
Symbol
Scer\GAL4Gr66a.3.153
Species
S. cerevisiae
Name
FlyBase ID
FBal0125296
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{Gr66C1-GAL4.3.153}
Also Known As
Gr66a-GAL4, Gr66a
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Scott et al., 2001)
Progenitor genotype
Carried in construct
P{Gr66C1-GAL4.3.153}
Cytology
Description

3.153kb of Gr66a promoter sequences regulate expression of a GAL4 driver.

(Scott et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
Gr66a_Gr66C1_CRM
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      larval stage
      terminal organ
      (Scott et al., 2001)
      embryonic/larval gut | restricted
      (Scott et al., 2001)
      gnathal ganglion
      (Scott et al., 2001)
      embryonic/larval mouth
      (Scott et al., 2001)
      adult stage
      labellum
      (Scott et al., 2001)
      cibarial sense organ
      (Scott et al., 2001)
      gustatory receptor neuron of proboscis
      (Wang et al., 2004)
      gustatory receptor neuron of labellum
      (Wang et al., 2004)
      gnathal ganglion
      (Wang et al., 2004)
      gustatory receptor neuron of adult mouth
      (Wang et al., 2004)
      gustatory receptor neuron of leg | faint
      (Wang et al., 2004)
      intermediate labellar taste bristle | faint
      (Hiroi et al., 2002)
      intermediate labellar taste bristle I-a | faint
      (Hiroi et al., 2002)
      intermediate labellar taste bristle I-b | faint
      (Hiroi et al., 2002)
      bitter-sensitive labellar taste bristle
      (Hiroi et al., 2002)
      short labellar taste bristle S-c | faint
      (Hiroi et al., 2002)
      short labellar taste bristle | faint
      (Hiroi et al., 2002)
      bitter-sensitive labellar taste bristle | faint
      (Hiroi et al., 2002)
      short labellar taste bristle S-b
      (Hiroi et al., 2002)
      gustatory receptor neuron of the labellum | subset of posterior maxillary sensory center
      (Miyazaki and Ito, 2010)
      gustatory receptor neuron of the adult pharynx | subset
      (Miyazaki and Ito, 2010)
      gustatory receptor neuron | subset of inferior pharyngeal sensory center
      (Miyazaki and Ito, 2010)
      gustatory receptor neuron of the labellum | subset of anterior maxillary sensory center
      (Miyazaki and Ito, 2010)
      short labellar taste bristle S-a
      (Hiroi et al., 2002)
      Additional Information
      Statement
      Reference

      Drives expression in a subset of bitter-responsive gustatory receptor neurons of the labellum, and in a few larval gustatory neurons.

      (FlyBase Curators, 2017)

      ScerGAL4Gr66a.3.153 drives expression in a subset of bitter-responsive gustatory receptor neurons (GRNs) of the labellum that project to regions PMS1-3 of the posterior maxillary sensory center. Labeled pharyngeal GRNs project to the VPS1 and VPS2 regions of the inferior pharyngeal sensory center and the PMS1 region of the posterior maxillary sensory center.

      (Miyazaki and Ito, 2010)

      ScerGAL4Gr66a.3.153 drives expression in approximately 25 neurons per labial palp, in a single neuron in most or all sensilla.

      (Wang et al., 2004)

      ScerGAL4Gr66a.3.153 expresses in 8-10 neurons innervating the medial most row of small bristles on the labellum. In larvae, ScerGAL4Gr66a.3.153 expresses in a single neuron in the terminal organ and two neurons in the mouth.

      (Scott et al., 2001)
       
      Marker for
      Reflects expression of
      Gr66a
      (Miyazaki and Ito, 2010, Wang et al., 2004, Hiroi et al., 2002, Scott et al., 2001)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Optogenetic activation (using Cnoc\ChR1Cs.IVS.20xUAS.Venus with 635 nm (red) light) of Scer\GAL4Gr66a.3.153 neurons results in a significant reduction in proboscis extension reflex in response to 100 mM sucrose presentation, compared to controls.

      (Kim et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Scer\GAL4Gr66C1.3.153
      Scer\GAL4Gr66a.3.153
      Name Synonyms
      Secondary FlyBase IDs
        References (28)