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Citation
Hoopfer, E.D., Jung, Y., Inagaki, H.K., Rubin, G.M., Anderson, D.J. (2015). P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila.  eLife 4(): e11346.
FlyBase ID
FBrf0230831
Publication Type
Research paper
Abstract

How brains are hardwired to produce aggressive behavior, and how aggression circuits are related to those that mediate courtship, is not well understood. A large-scale screen for aggression-promoting neurons in Drosophila identified several independent hits that enhanced both inter-male aggression and courtship. Genetic intersections revealed that 8-10 P1 interneurons, previously thought to exclusively control male courtship, were sufficient to promote fighting. Optogenetic experiments indicated that P1 activation could promote aggression at a threshold below that required for wing extension. P1 activation in the absence of wing extension triggered persistent aggression via an internal state that could endure for minutes. High-frequency P1 activation promoted wing extension and suppressed aggression during photostimulation, whereas aggression resumed and wing extension was inhibited following photostimulation offset. Thus, P1 neuron activation promotes a latent, internal state that facilitates aggression and courtship, and controls the overt expression of these social behaviors in a threshold-dependent, inverse manner.

PubMed ID
PubMed Central ID
PMC4749567 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    eLife
    Title
    eLife
    ISBN/ISSN
    2050-084X
    Data From Reference
    Alleles (29)
    Genes (14)
    Natural transposons (1)
    Insertions (6)
    Experimental Tools (4)
    Transgenic Constructs (27)
    Transcripts (8)