FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\TrpA1RNAi.A.UAS
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General Information
Symbol
Dmel\TrpA1RNAi.A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0220313
Feature type
allele
Associated gene
Dmel\TrpA1
Associated Insertion(s)
Carried in Construct
P{UAS-TrpA1.RNAi.A}
Key Links
Transgenic product class
RNAi_reagent
(Hamada et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Hamada et al., 2008)
Mutagen
in vitro construct
(Hamada et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-TrpA1.RNAi.A}
Cytology
Description

UAS regulatory sequences drive expression of a TrpA1 RNAi construct.

(Hamada et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
TrpA1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of TrpA1dsRNA.A.UAS and TrpA1dsRNA.B.UAS under the control of Scer\GAL4TrpA1.SH significantly reduces temperature, but not shock, olfactory memory, compared to controls.

      (Galili et al., 2014)

      Flies co-expressing TrpA1dsRNA.A.Scer\UAS and TrpA1dsRNA.B.Scer\UAS under the control of one of Scer\GAL4TrpA1.SH, Scer\GAL4Appl.G1a or Scer\GAL4Cha.7.4 show an altered distribution along a thermal gradient compared to wild-type flies. The mutant flies show increased accumulation in the warmest regions (28-32[o]C) of the gradient. Flies co-expressing TrpA1dsRNA.A.Scer\UAS and TrpA1dsRNA.B.Scer\UAS under the control of either Scer\GAL4Cha.1.2 or Scer\GAL4Dll-md23 do not show a disruption in warmth avoidance.

      (Hamada et al., 2008)

      Cooverexpression of two copies of TrpA1dsRNA.A.Scer\UAS and two copies of TrpA1dsRNA.B.Scer\UAS with Scer\GAL4P2.4.Pdf results in an increase in arousal state stability between ZT12 and ZT15 when the animals are transferred from 22[o]C to 27[o]C.

      (Parisky et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      TrpA1RNAi.A.UAS
      TrpA1dsRNA.A.Scer\UAS
      TrpA1dsRNA.A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (5)