FB2026_02 , released June 18, 2026
Allele: Dmel\TrpA1W903
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General Information
Symbol
Dmel\TrpA1W903
Species
D. melanogaster
Name
FlyBase ID
FBal0267190
Feature type
allele
Associated gene
Dmel\TrpA1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Zhong et al., 2012)
Progenitor genotype
Cytology
Description

Amino acid replacement: W903term.

(Zhong et al., 2012)

Nucleotide substitution: G?A.

(Zhong et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:8,895,749..8,895,749 [-]
Nucleotide change:

G8895749A

Reported nucleotide change:

G?A

Amino acid change:

W938term | TrpA1-PG; W937term | TrpA1-PH; W903term | TrpA1-PI; W902term | TrpA1-PJ; W901term | TrpA1-PK

Reported amino acid change:

W903term

Comment:

TGG to TAG nonsense mutation in codon Trp903. Sequence of mutant region in Figure S1.

(Zhong et al., 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      TrpA1W903 mutant larvae show a delayed nocifensive escape locomotion response compared to wild type flies. When gently touched with a 46[o]C probe many mutant flies fail to initiate escape behaviour within 10 seconds, compared to 3 seconds in wild type. Normal noxious heat responses are seen in TrpA1W903 mutant heterozygotes. TrpA1W903 mutants also show delayed mechanical nociception responses when stimulated with a 30mN von Frey fiber. However the response to gentle touch and gross motor functions both appear normal.

      TrpA1W903/Df(3L)ED4415 mutant larvae show a delayed nocifensive escape locomotion response compared to wild type flies. When gently touched with a 46[o]C probe many mutant flies fail to initiate escape behaviour within 10 seconds, compared to 3 seconds in wild type. Only very mild noxious heat responses are seen in Df(3L)ED4415 mutant heterozygotes. TrpA1W903/Df(3L)ED4415 mutants also show delayed mechanical nociception responses when stimulated with a 30mN von Frey fiber. However the response to gentle touch and gross motor functions both appear normal.

      (Zhong et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      TrpA1W903 is rescued by TrpA1UAS.C.cZa/Scer\GAL4ppk.1.9

      (Zhong et al., 2012)
      Comments

      Df(3L)ED4415 fails to complement the delayed nocifensive locomotion response seen in TrpA1W903. Df(3L)ED4415/+ larvae display only mild defects.

      Expression of TrpA1+t21 rescues the thermal and mechanical nociception defects seen in TrpA1W903 mutant larvae.

      Expression of TrpA1Scer\UAS.C.cZa under the control of Scer\GAL4ppk.1.9 rescues the thermal nociception phenotypes seen in TrpA1W903/Df(3L)ED4415 mutant larvae. In addition, expression of TrpA1Scer\UAS.C.cZa does not lower the behavioural threshold for thermal nociception. The mechanical nociception phenotypes seen in TrpA1W903/Df(3L)ED4415 mutants are not rescued.

      (Zhong et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      TrpA1W903
      dTrpA1W903*
      (Zhong et al., 2012)
      trpA1W903*
      (Tang et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)