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General Information
Symbol
Dmel\nandy5
Species
D. melanogaster
Name
FlyBase ID
FBal0146992
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

Imprecise excision of P{lacW}519 has caused a deletion that removes bases -3330 to +1746 with respect to the nan start codon.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of P{lacW}519 has caused a deletion that removes bases -3330 to +1746 with respect to the nan start codon.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

nandy5 mutant adults have significantly increased water consumption, compared to controls.

Homozygous flies show disrupted hygrosensing behaviour; a higher fraction of flies choose moist air (100% humidity) over dry air (0% humidity) compared to wild-type controls in a hygrosensory behaviour assay after five minutes.

Mutants show an impaired electrophysiological response to dry air, while leaving moist air sensing unaffected (recordings were taken at the base of the 2nd antennal segment in these experiments).

Homozygotes and nandy5/nan36a transheterozygous adults are viable but show abnormal behaviour: they are sedentary, mildly uncoordinated, more likely than wild-type flies to fall whilst climbing, and slower to right themselves after a fall. Homozygotes show a loss of sound-evoked potentials when the antennal extracellular potentials are recorded. Mutant chordotonal organs appear to have normal ultrastructure.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

As in either mutant alone, nandy5 Dnah3MB05004 double mutants entirely lack sound-evoked electrical potentials. Mechanical amplification is excessive in the double mutants, similar to Dnah3MB05004 mutants, substantially lower than in nandy5 mutants alone.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (4)