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General Information
Symbol
Dmel\Dnah3MB05004
Species
D. melanogaster
Name
FlyBase ID
FBal0212592
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Insertion components
    Mi{ET1}Dnah3MB05004
    Product class / Tool use(s)
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Electrical sound responses of Johnston's organ neurons are virtually abolished in Dnah3MB05004 mutant flies. Mechanical amplification is excessive compared to controls.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    NOT suppressed by
    Statement
    Reference
    Suppressor of
    Statement
    Reference
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    As in either mutant alone, nandy5 Dnah3MB05004 double mutants entirely lack sound-evoked electrical potentials. Mechanical amplification is excessive in the double mutants, similar to Dnah3MB05004 mutants, substantially lower than in nandy5 mutants alone.

    No gross morphological defects are seen in the Johnston's organ neurons in Dnah3MB05004 mutant flies and the outer dynein arms in the proximal region of the cilium persist and seem structurally uncompromised.

    Sperm from Dnah3MB05004/Df(3L)BSC371 mutant males shows a significant reduction in sperm competition compared with controls.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Rescued by
    Comments

    Expression of Dnah3+tWT rescues the sound-evoked electrical and mechanical response defects seen in Dnah3MB05004 mutant flies.

    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer

    Separable from: a secondary uncharacterised mutation that causes male fertility and sperm motility defects.

    Comments
    Comments

    Precise excision of the Mi{ET1}Dnah3MB05004 element restores the sound-evoked electrical and mechanical response defects seen in Dnah3MB05004 mutant flies.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Symbol Synonym
    CG17150MB05004
    Dnah3MB05004
    Name Synonyms
    Secondary FlyBase IDs
      References (2)