FB2026_02 , released June 18, 2026
Allele: Dmel\hbKM
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General Information
Symbol
Dmel\hbKM
Species
D. melanogaster
Name
FlyBase ID
FBal0045838
Feature type
allele
Associated gene
Dmel\hb
Associated Insertion(s)
Carried in Construct
P{KM}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Margolis et al., 1995)
Progenitor genotype
Carried in construct
P{KM}
Cytology
Description

KpnI-SmaI fragment of genomic DNA containing hb and both the P1 and P2 transcription start sites.

(Margolis et al., 1995)
Allele components
Component
Use(s)
Regulatory region(s)
hb
hb_KM
Encoded product / tool
hb
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In hbKM, hb12 animals, a duplication of interneuron 2 is seen at the expense of the first born 1/1G neurons. In these mutants the aCC and RP2 motorneurons fail to project their proper dorsal muscle target, suggesting a transformation of GMC-1 to a later born GMC fate. Mutants show a general reduction in the number of motorneuron projections, particularly to the dorsal muscles. Mutants lack the first born MM-CB glia at the midline.

      (Isshiki et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      hbKM partially rescues hb12

      (Margolis et al., 1995)
      Comments

      The addition of hbKM rescues the anterior defects, but not the posterior of hb12.

      (Margolis et al., 1995)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      hbKM
      Name Synonyms
      Secondary FlyBase IDs
        References (3)