FlyBase Allele Report: Scer\GAL4[GMR75C02]

General Information

Symbol

Scer\GAL4^GMR75C02

Species

S. cerevisiae

Name

FlyBase ID

FBal0254736

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

Carried in Construct

P{GMR75C02-GAL4}

Also Known As

R75C02-GAL4, Pair1-Gal4

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Pfeiffer et al., 2011.2.9)

Progenitor genotype

Carried in construct

P{GMR75C02-GAL4}

Cytology

Description

A 1957 base pair fragment from the flanking non-coding or intronic region of CG32606 is fused upstream of a Drosophila core synthetic promoter (DSCP) that is followed by sequence encoding a GAL4 driver.

(Pfeiffer et al., 2011.2.9)

Allele components

Component

Use(s)

Regulatory region(s)

GMR75C02

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

second instar larval stage -- pupal stage

larval pair1 neuron

(Lee and Doe, 2021)

third instar larval stage

larval pair1 neuron

(Tastekin et al., 2018)

pharate adult stage -- adult stage

adult pair1 neuron

Comment: NEEDS FBBT

(Lee and Doe, 2021)

Additional Information

Statement

Reference

ScerGAL4^GMR75C02 drives expression in pair1 neurons from 28 hours after hatching through adulthood.

(Lee and Doe, 2021)

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | larval stage | conditional, with Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus}

(Tastekin et al., 2018)

abnormal neuroanatomy, with bcd^GL00407

(Lee et al., 2022)

abnormal neuroanatomy, with bcd^HMS00824

(Lee et al., 2022)

abnormal neuroanatomy, with hb^HMS01183

(Lee et al., 2022)

increased rate of movement | larval stage | conditional, with Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus}

(Tastekin et al., 2018)

Phenotype Manifest In

larval head | conditional, with Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus}

(Tastekin et al., 2018)

larval pair1 neuron, with bcd^GL00407

(Lee et al., 2022)

larval pair1 neuron, with bcd^HMS00824

(Lee et al., 2022)

larval pair1 neuron, with hb^HMS01183

(Lee et al., 2022)

synapse | increased number, with bcd^GL00407

(Lee et al., 2022)

synapse | increased number, with bcd^HMS00824

(Lee et al., 2022)

synapse | increased number, with hb^HMS01183

(Lee et al., 2022)

Detailed Description

Statement

Reference

Optogenetic activation (using Cnoc\ChR1^{Cs.IVS.20xUAS.Venus} with 625 nm (red) light) of Scer\GAL4^GMR75C02 neurons in third instar larvae significantly increases stopping and head-casting behavior, compared to controls.

(Tastekin et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

39886

w¹¹¹⁸; P{GMR75C02-GAL4}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Scer\GAL4^GMR75C02

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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