FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\hbD1
Open Close
General Information
Symbol
Dmel\hbD1
Species
D. melanogaster
Name
Dominant
FlyBase ID
FBal0005413
Feature type
allele
Associated gene
Dmel\hb
Associated Insertion(s)
Carried in Construct
Also Known As
Rg-pbx, hbRg-pbx
Key Links
Allele class

gain of function allele

neomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Bender et al., 1988, Bender et al., 1987)

neomorphic allele - genetic evidence

(Bender et al., 1988, Carroll and Scott, 1986, Capdevila and Garcia-Bellido, 1981)
Mutagen
ethyl methanesulfonate
Progenitor genotype
Caused by aberration
In(3R)hbD1
Cytology

associated with proximal breakpoint.

Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homeotic transformation of halteres to wing. Hemizygotes survive to adulthood.

      (Bender et al., 1988)

      Transformation of posterior haltere to wing in the adult cuticle.

      (Bender et al., 1987)

      Adult heterozygotes show transformation of T3p to T2p (haltere to wing).

      (Carroll and Scott, 1986)

      Posterior haltere to wing transformation of hbD1 is affected by ftz mutations.

      (Duncan, 1986)

      T3p is transformed towards T1p: The bristles on the posterior margin of the femur change from short to long bristles.

      (Casanova et al., 1985)

      The frequency of variegated bithorax transformations seen in Df(3R)red-P52 heterozygotes and the frequency of variegated postbithorax transformations seen in hbD1 heterozygotes is increased in Df(3R)red-P52 hbD1 double heterozygotes.

      (Capdevila and Garcia-Bellido, 1981)

      A gain-of-function mutation; viable both in heterozygous and homozygous condition. Phenotype resembles that of pbx; insensitive to additional doses of hb+ but suppressed by extra doses <up>e. g., five copies of the bithorax complex+ (Lewis)</up>; enhanced in heterozygous combination with null alleles of ftz.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      hbD1 has phenotype, enhanceable by ftz11

      (Bender et al., 1987)

      hbD1 has phenotype, enhanceable by ftz3

      (Bender et al., 1987)

      hbD1 has phenotype, enhanceable by ftz6

      (Bender et al., 1987)

      hbD1 has phenotype, enhanceable by ftzRpl

      (Bender et al., 1987)

      hbD1 has phenotype, enhanceable by ftz10

      (Bender et al., 1987)

      hbD1 has phenotype, enhanceable by ftzc5

      (Bender et al., 1987)
      Enhancer of
      Statement
      Reference

      hbD1 is an enhancer of epidermis phenotype of ftzRpl

      (Bender et al., 1987)

      hbD1 is an enhancer of nervous system phenotype of ftzRpl

      (Bender et al., 1987)

      hbD1 is an enhancer of nervous system phenotype of ftz11

      (Bender et al., 1987)

      hbD1 is an enhancer of epidermis phenotype of ftz3

      (Bender et al., 1987)

      hbD1 is an enhancer of nervous system phenotype of ftz3

      (Bender et al., 1987)

      hbD1 is an enhancer of epidermis phenotype of ftz6

      (Bender et al., 1987)

      hbD1 is an enhancer of nervous system phenotype of ftz6

      (Bender et al., 1987)

      hbD1 is an enhancer of epidermis phenotype of ftz10

      (Bender et al., 1987)

      hbD1 is an enhancer of nervous system phenotype of ftz10

      (Bender et al., 1987)

      hbD1 is an enhancer of epidermis phenotype of ftzc5

      (Bender et al., 1987)

      hbD1 is an enhancer of nervous system phenotype of ftzc5

      (Bender et al., 1987)

      hbD1 is an enhancer of epidermis phenotype of ftz11

      (Bender et al., 1987)
      Other
      Statement
      Reference

      ftzRpl, hbD1 has haltere phenotype

      (Bender et al., 1987)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Transformation of posterior haltere to wing in the adult cuticle is sensitive to gene dosage of ftz.

      (Bender et al., 1987)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Bacher.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      Rg pbx
      (Carroll and Scott, 1986)
      Rg-pbx
      (Botas et al., 1988, Bender et al., 1987, Tearle and Nusslein-Volhard, 1987, Capdevila and Garcia-Bellido, 1981)
      Rgpbx
      (Casanova et al., 1985)
      hbD1
      hbRg-pbx
      (Bender et al., 1988, Duncan, 1986)
      Name Synonyms
      Dominant
      Regulator of postbithorax
      Secondary FlyBase IDs
        References (9)