FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term neuroblast NB3-3 ID (Ontology) FBbt:00001422 (Fly Anatomy)
Definition Neuroblast that delaminates predominantly at S4 (Schmid et al., 1999). Its first embryonic division produces a ganglion mother cell, which generates a motor neuron (Baumgardt et al., 2014; Wang et al., 2022). Subsequent divisions are type 0, self-renewing and directly producing EL neurons as a Notch OFF hemilineage (Baumgardt et al., 2014; Wang et al., 2022). In the embryo, one of these neuroblasts can be found in each hemisegment from S2-A9 (Birkholz et al., 2013; Urbach et al., 2016). In the larva, it resumes proliferation in all thoracic segments (Lacin and Truman, 2016). The neurons that develop from this neuroblast after larval hatching form postembryonic lineage 8 (Lacin and Truman, 2016).[ FlyBase:FBrf0098344 FlyBase:FBrf0180161 FlyBase:FBrf0221210 FlyBase:FBrf0225698 FlyBase:FBrf0228122 FlyBase:FBrf0231327 FlyBase:FBrf0232096 FlyBase:FBrf0254149 ]
Also Known As"lineage 8 neuroblast" ; "lineage NB3-3 neuroblast" ; "NB 8" (for all, see Synonyms field below)
CommentBirkholz et al. (2015) suggest that NB3-3 generates postembryonic lineage 13 and NB2-4 generates postembryonic lineage 8, but Lacin and Truman (2016) provide lineage tracing and marker data showing that NB3-3 generates lineage 8.
Links to External Ontologies
VFB:FBbt_00001422
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Data ClassFieldDirect annotations
Alleles (FBal)PHENOTYPE_MANIFEST_IN
Insertions (FBti)EXPRESSION_STAGE_TISSUE_POSITION
Insertions (FBti)PHENOTYPE_MANIFEST_IN
Constructs (FBtp)PHENOTYPE_MANIFEST_IN
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 Alleles Genes Insertions Constructs
 neuroblast NB3-3 (all annotations which use CV term, excluding "NOT" statements)
     neuroblast NB3-3 | embryonic stage
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central nervous system
 |__segmentally-repeated neuroblast__
neuroblast                           |
 |__stage 4 neuroblast_______________|
 |__segmentally-repeated neuroblast__|
ectodermal derivative                |
 |__segmentally-repeated neuroblast__|
                                     neuroblast NB3-3  39 rec.
                                      |__abdominal neuroblast NB3-3
                                      |__labial neuroblast NB3-3
                                      |__maxillary neuroblast NB3-3
                                      |__thoracic neuroblast NB3-3
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Is a stage 4 neuroblast
segmentally-repeated neuroblast
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VFB:FBbt_00001422